Altered levels of Ets-1 transcription factor and matrix metalloproteinases in melanocytes from patients with vitiligo

Kumar, Ravinder; Parsad, Davinder; Kanwar, A.J.; Kaul, Deepak

doi:10.1111/j.1365-2133.2011.10324.x

Cited by 60 publications

(52 citation statements)

References 31 publications

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“…The results of M6 were better than those of M3, suggesting a sufficient treatment period should be no less than 6 months. Re-pigmentation in vitiligo is known to be initiated by activation, proliferation, and migration of melanoblasts from the outer root sheath of hair follicles or melanocytes from the border area of vitiligo lesions into the depigmented epidermis [15]. The mechanisms of repigmentation induced by our triple combination treatment protocol may be explained as follows: (1) the fractional Er:YAG laser treatment, which is performed over the vitiligo lesion, allows for resettlement of migrating melanocytes [4]; (2) the topical corticosteroid used here contains betamethasone disodiumphosphate (fast-acting) and betamethasone dipropionate (slow-acting) [14].…”

Section: Discussionmentioning

confidence: 99%

Fractional Er:YAG laser assisting topical betamethasone solution in combination with NB-UVB for resistant non-segmental vitiligo

et al. 2017

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Resistant non-segmental vitiligo is difficult to be treated. Ablative erbium-YAG (Er:YAG) laser has been used in the treatment of vitiligo, but the ablation of entire epidermis frustrated the compliance of patients. The purpose of this study is to investigate the effects of fractional Er:YAG laser followed by topical betamethasone and narrow band ultraviolet B (NB-UVB) therapy in the treatment of resistant nonsegmental vitiligo. The vitiligo lesions of each enrolled patient were divided into four treatment parts, which were all irradiated with NB-UVB. Three parts were, respectively, treated with low, medium, or high energy of Er:YAG laser, followed by topical betamethasone solution application. A control part was spared with laser treatment and topical betamethasone. The treatment period lasted 6 months. The efficacy was assessed by two blinded dermatologists. Treatment protocol with high energy of 1800 mJ/P of fractional Er:YAG laser followed by topical betamethasone solution and in combination with NB-UVB made 60% patients achieve marked to excellent improvement in white patches. The protocol with medium energy of 1200 mJ/P of laser assisted approximate 36% patients achieve such improvement. The two protocols, respectively, showed better efficacies than NB-UVB only protocol. However, fractional Er:YAG laser at low energy of 600 mJ/P did not provide such contributions to the treatment of vitiligo. The fractional Er:YAG laser in combination with topical betamethasone solution and NB-UVB was suitable for resistant non-segmental vitiligo. The energy of laser was preferred to be set at relatively high level.

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Section: Discussionmentioning

confidence: 99%

Fractional Er:YAG laser assisting topical betamethasone solution in combination with NB-UVB for resistant non-segmental vitiligo

et al. 2017

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“…[9] Kumar et al . [10] correlate this with impaired expression of matrix metalloproteinase-2, needed for detachment and degradation of denatured collagen and collagen Types IV, V, VII, IX, and X. It plays a role in migration through laminin.…”

Section: The Basal Keratinocyte and Its Mentor The Melanocytementioning

confidence: 99%

“…postulate that the transcription factor Ets-1 is involved and that in vitiligo skin samples it is absent. [10]…”

Section: The Basal Keratinocyte and Its Mentor The Melanocytementioning

confidence: 99%

Human pigmentation: A side effect adapted from a primitive organism′s survival. Part 2: The melanocyte as mentor of the keratinocye

Arianayagam

Ryan

2014

Indian Dermatol Online J

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Pigmentation featured millions of years ago and perhaps began with an amoeba frightening off a predator with some agent such as dopamine to prevent its attachment for phagocytosis by an enemy. This paper suggests that the environmental forces of grip and stick, rather than pure chemical influences, deserve greater emphasis, and that the influence of the mechanical forces involved in grip and stick or release from attachment, all point to control of proteases as a function underlying pigmentation. How and why pigmentation varies with temperature and sunlight is discussed. The toxicity of melanin, pH, transepidermal water loss, and the influence of endocrine factors are also addressed.

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“…Vitiligo melanocytes do not grow well in culture, have ultra structural defects and, according to Jimbow et al 23 , have stubby dendrites. Kumar et al 24 correlate this with impaired expression of matrix metalloproteinase-2, needed for detachment and degradation of denatured collagen and collagen types IV, V, VII, IX and X. It plays a role in migration through laminin.…”

Section: Vitiligomentioning

confidence: 99%

“…It plays a role in migration through laminin. They also postulate that the transcription factor Ets-1 is involved and that it is absent in vitiligo skin samples 24 . There are three main biomedical theories for the aetiology of vitiligo: the autoimmune hypothesis, the neurogenic hypothesis and Lerner's self-destruct hypothesis.…”

Section: Vitiligomentioning

confidence: 99%

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Arianayagam

Ryan

2016

Current Science

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Biomedicine has not provided a complete explanation with fully effective therapies for disorders of pigmentation. Biomedicine emphasizes the role of melanocyte for protection from UV rays and as a determinant of skin colour. These important properties acquired a genetic basis much later than other functions, many relating to cell contact as in the keratinocyte -melanocyte unit, or as with the synapses of the neurological system. There are other roles, biochemical and mechanical, of melanocyte. Management that is inclusive of a maximally holistic approach justifies the use of diverse herbals, yoga and concern for cultural awareness provided by integrated medicine. Vitiligo provides a model which demonstrates that Ayurveda has a richer view of its presentations, possibly a stronger line on its pathogenesis, and a huge range of herbals, many now backed by studies from ethnobotanical laboratories, awaiting research into the many possible mechanisms by which they may act in the wide and complex field of melanocyte biochemistry.

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Altered levels of Ets-1 transcription factor and matrix metalloproteinases in melanocytes from patients with vitiligo

Cited by 60 publications

References 31 publications

Fractional Er:YAG laser assisting topical betamethasone solution in combination with NB-UVB for resistant non-segmental vitiligo

Fractional Er:YAG laser assisting topical betamethasone solution in combination with NB-UVB for resistant non-segmental vitiligo

Human pigmentation: A side effect adapted from a primitive organism′s survival. Part 2: The melanocyte as mentor of the keratinocye

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

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