Altered mRNA expression of telomere binding proteins (TPP1, POT1, RAP1, TRF1 and TRF2) in ulcerative colitis and Crohn's disease

DaSilva, Nancy A.; Arasaradnam, Ramesh P.; Getliffe, Katherine M.; Sung, Edmond; Oo, Ye Htun; Nwokolo, Chuka U.

doi:10.1016/j.dld.2009.12.005

Cited by 20 publications

(7 citation statements)

References 25 publications

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“…Another frequently used immunosuppressant among the present study population was azathioprine, an inhibitor of purine synthesis. It has not been shown to alter expression of telomere‐binding proteins, including TRF1 or TRF2, when studied among patients with inflammatory bowel disease . We found an increase in gene expression levels only in the KTx group.…”

Section: Discussionsupporting

confidence: 68%

“…It has not been shown to alter expression of telomerebinding proteins, including TRF1 or TRF2, when studied among patients with inflammatory bowel disease. 28 We found an increase in gene expression levels only in the KTx group. It is therefore tempting to speculate that the differences in shelterin protein expression between the KTx and NBL populations could be explained by ongoing immunosuppression only among the KTx recipients.…”

Section: Discussionmentioning

confidence: 62%

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Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer—A cross‐sectional study

Endén

Tainio

Hou

et al. 2019

Pediatric Transplantation

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Chronic diseases are known to cause premature aging and frailty. Data about telomere length and telomere length‐regulating proteins after pediatric KTx are scarce. Leukocyte telomere length and gene expression level of eight telomere‐binding proteins were analyzed in 20 KTx recipients, eight childhood NBL survivors, and nine healthy controls. The influence of key clinical parameters on telomere length and on regulators of telomere length was evaluated. The telomere length in the KTx recipients tended to be shorter (0.53 AU) than in the healthy controls (0.64 AU) but longer than in the NBL survivors (0.38 AU). There was no significant difference in telomere length between the NBL survivors and the KTx recipients (P = .110). The gene expression level of telomere length‐preserving protein RPA1 was significantly higher in the KTx recipients than among the NBL survivors or healthy controls, while the expression of TRF2 and the tumor suppressor gene p16 was significantly higher in the KTX recipients when compared to the controls. TRF2 and TIN2 correlated significantly with hsCRP; additionally, TRF2 showed significant correlation with plasma creatinine and eGFR. KTx recipients have near to normal telomere length, but they have significantly higher gene expression levels of telomere regulatory proteins compared with healthy controls, suggesting activation of mechanisms preserving telomere length among KTx recipients. Our results suggest that declined graft function and consequent inflammatory response may have influence on telomerase activity.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 62%

Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer—A cross‐sectional study

Endén

Tainio

Hou

et al. 2019

Pediatric Transplantation

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“…More importantly, TRF2 protects human telomeres against end-to-end fusions, and thus, TRF2 plays a key role in maintaining telomere integrity. 34 We observed decreased mRNA and protein levels of POT1 and TRF1 (Fig. 4A, B and 7A, B) and increased levels of TRF2 (Fig.…”

Section: Discussionmentioning

confidence: 63%

Changes in telomere length and telomerase activity in human bronchial epithelial cells induced by coal tar pitch extract

Feng

Yang

et al. 2015

Toxicol. Res.

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“…Cells deficient in functional TBPs undergo striking chromosomal instability. For example, we have found reduced TRF2 mRNA expression (one of the TBPs) in peripheral lymphocytes in UC as well as an association between mRNA expression of RAP1 (another TBP) and 5-aminosalicylate consumption 5. These findings serve to suggest that perhaps TBPs should be explored further in CRC, particularly its role as a prognostic marker.…”

mentioning

confidence: 65%

Epiphenomenon of telomere lengths: lessons from ulcerative colitis

Arasaradnam

Nwokolo

2012

Gut

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Altered mRNA expression of telomere binding proteins (TPP1, POT1, RAP1, TRF1 and TRF2) in ulcerative colitis and Crohn's disease

Cited by 20 publications

References 25 publications

Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer—A cross‐sectional study

Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer—A cross‐sectional study

Changes in telomere length and telomerase activity in human bronchial epithelial cells induced by coal tar pitch extract

Epiphenomenon of telomere lengths: lessons from ulcerative colitis

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