Altered serum uric acid level in lichen planus patients

Abstract

Background:Lichen planus (LP) is a common disorder whose etiopathogenesis is not clear. Recently, it has been suggested that increased reactive oxygen species (ROS) play important roles in the underlying mechanism of LP.Objectives:The principal aim of this study was to evaluate serum uric acid (UA) levels as a measure of the antioxidant defense status in LP patients.Methods:Serum UA levels were determined in 58 LP patients and 61 controls.Results:Serum UA levels were significantly decreased in patients with respect to controls. Moreover, serum UA level was decreased according to increasing duration of disease.Conclusions:The results of our study suggest that LP is associated with decrease of UA levels in serum. UA may be a potential, useful biomarker of antioxidant status in LP for elaboration of treatment strategy and monitoring.

Roles of serum uric acid, prolactin levels, and psychosocial factors in oral lichen planus

“…The imbalance between the production of ROS and the ability of the biological system to detoxify reactive intermediates and easily repair the resultant damage constitutes oxidative stress (5,6). The primary defense against oxidative stress includes antioxidants, such as selenium, bilirubin, enzymes like catalase, superoxide dismutase, and glutathione peroxidase, as well as the vitamins C, D, and E, and the end-products of lipid peroxidation, such as monoaldehyde and UA (12)(13)(14). UA was chosen for analysis in the present study because it is the most abundant antioxidant and accounts for up to 60% of serum-free radical scavenging capacity (11,12).…”

“…The primary defense against oxidative stress includes antioxidants, such as selenium, bilirubin, enzymes like catalase, superoxide dismutase, and glutathione peroxidase, as well as the vitamins C, D, and E, and the end-products of lipid peroxidation, such as monoaldehyde and UA (12)(13)(14). UA was chosen for analysis in the present study because it is the most abundant antioxidant and accounts for up to 60% of serum-free radical scavenging capacity (11,12). Blood samples were collected between 10:00 and 12:00 h as PRL shows diurnal variation and increases in the early morning at around 08:00 h. There is no diurnal variation in serum UA levels (21,22).…”

“…However, there is a lack of available data in the literature regarding serum UA levels in LP patients, particularly from India. Among existing reports, there are conflicting accounts of the association of UA levels among LP patients, as some found decreased levels of UA (12)(13)(14) suggesting oxidative stress, while others failed to find any difference (15).…”

“…UA is an important antioxidant in plasma that scavenges ROS and chelates metal ions (11,12). Thus, monitoring of serum UA levels as an indicator of antioxidant defense (oxidative balance) could be an important clinical treatment strategy.…”

Study of serum uric acid levels in lichen planus

“…This study is in correlation with Chakraborti with mean serum UA levels in patients and controls were 3.6 and 3.94 mg/dl, respectively. 9 The difference of means is 0.34 mg/dl. A significant decrease of UA levels was also observed in study of LP patients from Italy.…”