Altitude training induced alterations in erythrocyte rheological properties: A controlled comparison study in rats

Bor-Küçükatay, Melek; Çolak, Rıdvan; Erken, Gülten; Kilic‐Toprak, Emine; Küçükatay, Vural

doi:10.3233/ch-131711

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…Hemorheological properties can help evaluate the oxygen delivery and utilization capacity in various subjects, for different exercise methods and exercise intensities, and between sexes [ 23 , 36 , 37 , 38 ]. In particular, hemorheological properties, including erythrocyte deformability and aggregation, are very important parameters because they are related to the surrounding microcirculation tissue and facilitate the exchange of oxygen and carbon dioxide [ 22 ]. In their study related to hypoxia and hemorheological properties, Grau et al [ 39 ] investigated the impact of mild-to-severe hypoxia on human erythrocyte-nitric oxide synthase (NOS)-dependent nitric oxide production, protein S-nitrosylation, and deformability.…”

Section: Discussionmentioning

confidence: 99%

“…Hemorheological properties such as erythrocyte deformability and aggregation affect the oxygen delivery capacity of active skeletal muscles [ 21 , 22 ]. The blood flow through capillaries, which are smaller in diameter than erythrocytes and microcirculation, is accompanied by erythrocyte deformability [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…The blood flow through capillaries, which are smaller in diameter than erythrocytes and microcirculation, is accompanied by erythrocyte deformability [ 21 ]. Erythrocyte deformability is an energy-dependent process, and healthy erythrocytes with high deformability show a high correlation with oxygen-carrying capacity and aerobic capacity [ 21 , 22 , 23 ]. Erythrocyte aggregation also refers to the binding of two erythrocytes, such as one-dimensional rouleaux formation.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic, Cardiac, and Hemorheological Responses to Submaximal Exercise under Light and Moderate Hypobaric Hypoxia in Healthy Men

Park

Kim

Nam³

2022

Biology

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We compared the effects of metabolic, cardiac, and hemorheological responses to submaximal exercise under light hypoxia (LH) and moderate hypoxia (MH) versus normoxia (N). Ten healthy men (aged 21.3 ± 1.0 years) completed 30 min submaximal exercise corresponding to 60% maximal oxygen uptake at normoxia on a cycle ergometer under normoxia (760 mmHg), light hypoxia (596 mmHg, simulated 2000 m altitude), and moderate hypoxia (526 mmHg, simulated 3000 m altitude) after a 30 min exposure in the respective environments on different days, in a random order. Metabolic parameters (oxygen saturation (SPO2), minute ventilation, oxygen uptake, carbon dioxide excretion, respiratory exchange ratio, and blood lactate), cardiac function (heart rate (HR), stroke volume, cardiac output, and ejection fraction), and hemorheological properties (erythrocyte deformability and aggregation) were measured at rest and 5, 10, 15, and 30 min after exercise. SPO2 significantly reduced as hypoxia became more severe (MH > LH > N), and blood lactate was significantly higher in the MH than in the LH and N groups. HR significantly increased in the MH and LH groups compared to the N group. There was no significant difference in hemorheological properties, including erythrocyte deformability and aggregation. Thus, submaximal exercise under light/moderate hypoxia induced greater metabolic and cardiac responses but did not affect hemorheological properties.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metabolic, Cardiac, and Hemorheological Responses to Submaximal Exercise under Light and Moderate Hypobaric Hypoxia in Healthy Men

Park

Kim

Nam³

2022

Biology

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“…The variations of these blood factors are involved in hypoxia and altitude training. Most often, hypoxia or altitude conditions will result in increased RBC and HCT ( Bor-Kucukatay et al, 2014 ; Stokke et al, 1986 ). The present results from simulated altitude training reaffirm the view that a low oxygen environment boosts RBC and HCT.…”

Section: Discussionmentioning

confidence: 99%

Simulated altitude exercise training damages small intestinal mucosa barrier in the rats

Han²,

Zhang³

et al. 2018

J Exerc Rehabil

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This study investigated the effect of simulated altitude training on the changes of small intestinal mucosa barrier, bacterial overgrowth and inflammatory response in the small intestine of rat. Male 8-week-old Sprague-Dawley rats were randomly divided into four groups: normal oxygen sedentary group (n=30), normal oxygen exercise group (n=30), low oxygen sedentary group (n=30) and low oxygen exercise group (n=30). Exercise training was on a treadmill for 1 hr per day on days 3, 6, and 9 in the hypoxia condition. Hematological profiles, hematolxylin and eosin staining, fluorescence in situ hybridization, reverse transcription-polymerase chain reaction and Western blot were used to analyze the effect of simulated altitude training on the amount of bacteria, and expression of mRNA and protein. Simulated exercise training significantly increased red blood cells and hematocrit. The small intestinal mucosa barrier was significantly injured by the simulated altitude exercise training. Comparatively more bacterial growth was evident in the small intestine by the simulated altitude exercise training. mRNA levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) and protein expression of nuclear factor-kappa B (NF-κB) were significantly elevated by simulated altitude exercise training. These results suggest that the simulated altitude exercise training may impair the small intestinal mucosa barrier via elevation of bacterial growth and inflammatory cytokines (IL-6, TNF-α) and the up-regulation of NF-κB in the rats.

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“…This research group demonstrated a reduction in the volume and deformability of human erythrocytes induced by hypoxic exercise. Conversely, conflicting results come from studies performed on laboratory animals [16,17]. Effects of living and training at different altitudes on red blood cell deformability and erythrocyte aggregation were studied by Bor-Kucukatay et al in Sprague Dawley rats [16].…”

Section: Haemorheological Changes With Altitudementioning

confidence: 99%

Microcirculatory and Rheological Adaptive Mechanisms at High Altitude in European Lowlander Hikers and Nepalese Highlanders

Salvi

Grillo

Brunacci

et al. 2023

JCM

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Background: Physical activity at high-altitudes is increasingly widespread, both for tourist trekking and for the growing tendency to carry out sports and training activities at high-altitudes. Acute exposure to this hypobaric–hypoxic condition induces several complex adaptive mechanisms involving the cardiovascular, respiratory and endocrine systems. A lack of these adaptive mechanisms in microcirculation may cause the onset of symptoms of acute mountain sickness, a frequent disturbance after acute exposure at high altitudes. The aim of our study was to evaluate the microcirculatory adaptive mechanisms at different altitudes, from 1350 to 5050 m a.s.l., during a scientific expedition in the Himalayas. Methods: The main haematological parameters, blood viscosity and erythrocyte deformability were assessed at different altitudes on eight European lowlanders and on a group of eleven Nepalese highlanders. The microcirculation network was evaluated in vivo by conjunctival and periungual biomicroscopy. Results: Europeans showed a progressive and significant reduction of blood filterability and an increase of whole blood viscosity which correlate with the increase of altitude (p < 0.02). In the Nepalese highlanders, haemorheological changes were already present at their residence altitude, 3400 m a.s.l. (p < 0.001 vs. Europeans). With the increase in altitude, a massive interstitial oedema appeared in all participants, associated with erythrocyte aggregation phenomena and slowing of the flow rate in the microcirculation. Conclusions: High altitude causes important and significant microcirculatory adaptations. These changes in microcirculation induced by hypobaric–hypoxic conditions should be considered when planning training and physical activity at altitude.

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Altitude training induced alterations in erythrocyte rheological properties: A controlled comparison study in rats

Cited by 8 publications

References 39 publications

Metabolic, Cardiac, and Hemorheological Responses to Submaximal Exercise under Light and Moderate Hypobaric Hypoxia in Healthy Men

Metabolic, Cardiac, and Hemorheological Responses to Submaximal Exercise under Light and Moderate Hypobaric Hypoxia in Healthy Men

Simulated altitude exercise training damages small intestinal mucosa barrier in the rats

Microcirculatory and Rheological Adaptive Mechanisms at High Altitude in European Lowlander Hikers and Nepalese Highlanders

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