Aluminum: Interaction with Nucleotides and Nucleotidases and Analytical Aspects of Its Determination

Schetinger, Maria Rosa Chitolina; Morsch, Vera Maria; Bohrer, Denise

doi:10.1007/3-540-45425-x_4

Cited by 12 publications

(5 citation statements)

References 110 publications

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“…For most of the physiological and biochemical studies involving the putative AlFx, the fluoride source is usually NaF and the Al 3+ source is AlCl 3 . Moreover, Al 3+ is a frequent contaminant of commercial chemicals and it can be picked up from the glass surface, depending on the substance stored in the glass container [86]. The phenomenological observations seemed to verify that pH determines the complexation state of AlFx [20,87].…”

Section: Alfx Intervention Into Phosphoryl-transfer Reactionsmentioning

confidence: 99%

Fluoride Interactions: From Molecules to Disease

Strunecká¹,

Patočka²,

Blaylock³

et al. 2007

CST

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Fluoride has long been known to influence the activity of various enzymes in vitro. Later it has been demonstrated that many effects primarily attributed to fluoride are caused by synergistic action of fluoride plus aluminum. Aluminofluoride complexes have been widely used as analogues of phosphate groups to study phosphoryl transfer reactions and heterotrimeric G proteins involvement. A number of reports on their use have appeared, with far-reaching consequences for our understanding of fundamental biological processes. Fluoride plus aluminum send false messages, which are amplified by processes of signal transduction. Many investigations of the longterm administration of fluoride to laboratory animals have demonstrated that fluoride and aluminofluoride complexes can elicit impairment of homeostasis, growth, development, cognition, and behavior. Ameliorative effects of calcium, vitamins C, D, and E have been reported. Numerous epidemiological, ecological, and clinical studies have shown the effects of fluoride on humans. Millions of people live in endemic fluorosis areas. A review of fluoride interactions from molecules to disease is necessary for a sound scientific assessment of health risks, which may be linked to the chronic intake of small doses of fluoride and aluminum from environmental and artificial sources.

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Section: Alfx Intervention Into Phosphoryl-transfer Reactionsmentioning

confidence: 99%

Fluoride Interactions: From Molecules to Disease

Strunecká¹,

Patočka²,

Blaylock³

et al. 2007

CST

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“…Flasks were left at least 48 h in a cleaning solution (HNO 3 /ethanol mixture 1:9, v/v) and washed with ultra-purified water [4,23]. Animal decapitation, sample and reagent preparations were carried out on a Trox clean bench class 100.…”

Section: Contamination Controlmentioning

confidence: 99%

“…Due to its abundance every organism presents small quantities of aluminum [4][5][6] and it can be found practically in all tissues of mammals as the brain, liver, kidney, heart, blood and bones [1][2][3]7]. Aluminum may interfere with various metabolic processes, in which Ca 2+ , Mg 2+ , Fe 3+ (in transferrin and ferritin) and Fe 2+ (gastrointestinal absorption) are involved [8].…”

Section: Introductionmentioning

confidence: 99%

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Chelating effect of novel pyrimidines in a model of aluminum intoxication

Missel

Schetinger

Gioda

et al. 2005

Journal of Inorganic Biochemistry

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“…Aluminum (Al), the third most abundant element of the Earth's crust, is a nonessential and toxic metal in humans [1] . Due to its abundance, every organism contains small quantities of aluminum and it can be found in practically all of the tissues of mammals, including the brain, liver, kidney, heart, blood and bones [2] .…”

Section: Introductionmentioning

confidence: 99%

Camel's Milk Protects Against Aluminum Chloride-Induced Normocytic Normocromic Anemia, Lipid Peroxidation and Oxidative Stress in Erythrocytes of White Albino Rats

Al‐Hashem¹

2009

American Journal of Biochemistry and Biotechnology

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Problem statement: Aluminum (Al) is an indifferent element from a toxicological point of view. In recent years, however, Al has been implicated in the pathogenesis of several clinical disorders. One of the most frequently described problem in aluminum toxicity is anemia. The present study was carried out to determine the effectiveness of Camels milk in alleviating the toxicity of aluminum chloride (AlCl₃) on certain hematological parameters, lipid peroxidation and oxidative stress enzyme in the RBCs of white albino rats. Approach: Ten rats per group were divided into three treatment groups: Group one were rats given normal saline and served as control group, group two were rats treated with 1 ml of AlCl₃ (0.5 mg kg^-1 body weight) and named AlCl₃ treated rats, group 3 were rat treated with 1ml fresh camels milk 10 min before the administration of AlCl₃ (0.5 mg kg^-1 body weight) and named Camels milk and AlCl₃ treated rats. Rats were orally administered their respective doses every day for 30 days. Evaluations were made for hematological parameters in the blood and for lipid peroxidation and oxidative stress enzymes activities in the RBCs. Results: Results obtained showed that oral AlCl₃ treatment caused a significant decrease (p<0.05) in total erythrocytes count, blood Hemoglobin (Hb), hematocrite (PCV) and Serum iron levels, where as the values of Mean Corpuscular Volume (MCV), Mean Hemoglobin Concentration (MHC), Mean Corpuscular Hemoglobin Concentration (MCHC) and Total Ion Binding Capacity (TIBC) didnt change. Also oral administration of AlCl₃ induced free radicals and as a result caused an increase the concentration of Thiobarbituric Acid Reactive Substances (TBARS) and decreased activities of Superoxide Dismutase (SOD) and Catalsae (CAT) in the RBCs homolysate. The oral administration of Camels milk before the administration of AlCl₃, alleviated its toxic effect. Camels milk administration resulted in a significant increase (p<0.05) in the in total erythrocytes count, blood hemoglobin (Hb), hematocrite (PCV) and Serum iron with No change in the values of MCV, MHC, MCHC and TIBC when compared to AlCl₃ treated rats. Camels milk reduced free radicals production and oxidative stress status in the RBCs noticed by the significant decreased levels of TBARS and increased activities of SOD and CAT when compared to AlCl₃ treated rats. Conclusion: our data proved that there is an alternation in the hematological parameters and antioxidant system in the red blood cells of rats administered aluminum chloride orally, whereas oral administration of Camels milk prior the administration of Aluminum chloride protects the red blood cell form toxic effect of aluminum

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Aluminum: Interaction with Nucleotides and Nucleotidases and Analytical Aspects of Its Determination

Cited by 12 publications

References 110 publications

Fluoride Interactions: From Molecules to Disease

Fluoride Interactions: From Molecules to Disease

Chelating effect of novel pyrimidines in a model of aluminum intoxication

Camel's Milk Protects Against Aluminum Chloride-Induced Normocytic Normocromic Anemia, Lipid Peroxidation and Oxidative Stress in Erythrocytes of White Albino Rats

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