Alveolar bone repair with strontium- containing nanostructured carbonated hydroxyapatite

Carmo, André Boziki Xavier do; Sartoretto, Suelen Cristina; Alves, Adriana Terezinha Neves Novellino; Granjeiro, José Mauro; Miguel, Fúlvio Borges; Calasans-Maia, José de Albuquerque; Calasans-Maia, Mônica Diuana

doi:10.1590/1678-7757-2017-0084

Cited by 31 publications

(34 citation statements)

References 24 publications

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“…4,9 Junior et al 10 reported an improvement in the osteoconduction of nHAp in adult rats compared to biological HAp. Carmo et al 11 found similar results to those reported previously when using HAp-based nanocomposites and carbonate structures during osteoconduction and bone repair. However, its fragility and low resistance to mechanical stress have limited its use in orthopedic interventions.…”

Section: Introductionsupporting

confidence: 80%

<p>High loads of nano-hydroxyapatite/graphene nanoribbon composites guided bone regeneration using an osteoporotic animal model</p>

Oliveira¹,

Carvalho²,

Gusmão

et al. 2019

IJN

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BackgroundIt has been difficult to find bioactive compounds that can optimize bone repair therapy and adequate osseointegration for people with osteoporosis. The nano-hydroxyapatite (nHAp)/carbon nanotubes with graphene oxides, termed graphene nanoribbons (GNR) composites have emerged as promising materials/scaffolds for bone regeneration due to their bioactivity and osseointegration properties. Herein, we evaluated the action of nHAp/GNR composites (nHAp/GNR) to promote bone regeneration using an osteoporotic model.Materials and methodsFirst, three different nHAp/GNR (1, 2, and 3 wt% of GNR) were produced and characterized. For in vivo analyses, 36 Wistar rats (var. albinus, weighing 250–300 g, Comissão de Ética no Uso de Animais [CEUA] n.002/17) were used. Prior to implantation, osteoporosis was induced by oophorectomy in female rats. After 45 days, a tibial fracture was inflicted using a 3.0-mm Quest trephine drill. Then, the animals were separated into six sample groups at two different time periods of 21 and 45 days. The lesions were filled with 3 mg of one of the above samples using a curette. After 21 or 45 days of implantation, the animals were euthanized for analysis. Histological, biochemical, and radiographic analyses (DIGORA method) were performed. The data were evaluated through ANOVA, Tukey test, and Kolmogorov-Smirnov test with statistical significance at P<0.05.ResultsBoth nHAp and GNR exhibited osteoconductive activity. However, the nHAp/GNR exhibited regenerative activity proportional to their concentration, following the order of 3% >2% >1% wt.ConclusionTherefore, it can be inferred that all analyzed nanoparticles promoted bone regeneration in osteoporotic rats independent of analyzed time.

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Section: Introductionsupporting

confidence: 80%

<p>High loads of nano-hydroxyapatite/graphene nanoribbon composites guided bone regeneration using an osteoporotic animal model</p>

Oliveira¹,

Carvalho²,

Gusmão

et al. 2019

IJN

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“…The literature points out that strontium (Sr 2+ ) is used in treatments for osteoporosis, bone pain, and bone cancer and can exert double effects of bone stimulation. Studies suggest that the incorporation of Sr 2+ to calcium phosphates seems favorable to bone repair due to its induction properties in bone formation [ 23 , 24 , 46 ]. In a previous study [ 26 ], two concentrations of Sr 2+ were used, 5 wt% and 10 wt%, and it was found that the lower concentration (5%) had higher resistance to compression; however, the ideal dosage of Sr 2+ for incorporation to calcium phosphate is still unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The number of isomorphic substitutions that hydroxyapatite can undergo incorporating several ions into its structure can optimize its clinical performance, making it more soluble, spatially modifying its crystal structure and favoring its bioabsorption [ 10 ] Previous studies have already carried out the partial replacement of calcium by metals such as zinc [ 10 , 15 , 16 , 17 , 18 , 19 , 20 ] and strontium [ 21 , 22 , 23 , 24 , 25 , 26 ] which are capable of optimizing bone repair.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the In Vivo Biocompatibility of Amorphous Calcium Phosphate-Containing Metals

Moerbeck-Filho

Sartoretto

Uzeda

et al. 2020

JFB

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Among the biomaterials based on calcium phosphate, hydroxyapatite has been widely used due to its biocompatibility and osteoconduction. The substitution of the phosphate group by the carbonate group associated with the absence of heat treatment and low synthesis temperature leads to the formation of carbonated hydroxyapatite (CHA). The association of CHA with other metals (strontium, zinc, magnesium, iron, and manganese) produces amorphous calcium phosphate-containing metals (ACPMetals), which can optimize their properties and mimic biological apatite. This study aimed to evaluate the biocompatibility and biodegradation of ACPMetals in mice subcutaneous tissue. The materials were physicochemically characterized with Fourier Transform InfraRed (FTIR), X-Ray Diffraction (XRD), and Atomic Absorption Spectrometry (AAS). Balb-C mice (n = 45) were randomly divided into three groups: carbonated hydroxyapatite, CHA (n = 15), ACPMetals (n = 15), and without implantation of material (SHAM, n = 15). The groups were subdivided into three experimental periods (1, 3, and 9 weeks). The samples were processed histologically for descriptive and semiquantitative evaluation of the biological effect of biomaterials according to ISO 10993-6:2016. The ACPMetals group was partially biodegradable; however, it presented a severe irritating reaction after 1 and 3 weeks and moderately irritating after nine weeks. Future studies with other concentrations and other metals should be carried out to mimic biological apatite.

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“…For example, a nanostructured carbonate hydroxyapatite/calcium alginate (CHA) microsphere was developed by substituting the phosphate group (PO 4 ) with a carbonate group (CO 3 ). The microspheres produced at low temperatures showed lower crystallinity and higher solubility, which favored an earlier resorption time and improved bone regeneration [65,66]. When combined with collagen, nHA/collagen composite scaffolds aimed to mimic the architecture of native bone.…”

Section: Bone Regeneration For Dental Implants and Mandibular Defectsmentioning

confidence: 99%

Nanomaterials in Craniofacial Tissue Regeneration: A Review

Tao

Pham

et al. 2019

Applied Sciences

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Nanotechnology is an exciting and innovative field when combined with tissue engineering, as it offers greater versatility in scaffold design for promoting cell adhesion, proliferation, and differentiation. The use of nanomaterials in craniofacial tissue regeneration is a newly developing field that holds great potential for treating craniofacial defects. This review presents an overview of the nanomaterials used for craniofacial tissue regeneration as well as their clinical applications for periodontal, vascular (endodontics), cartilage (temporomandibular joint), and bone tissue regeneration (dental implants and mandibular defects). To enhance periodontal tissue regeneration, nanohydroxyapatite was used in conjunction with other scaffold materials, such as polylactic acid, poly (lactic-co-glycolic acid), polyamide, chitosan, and polycaprolactone. To facilitate pulp regeneration along with the revascularization of the periapical tissue, polymeric nanofibers were used to simulate extracellular matrix formation. For temporomandibular joint (cartilage) engineering, nanofibrous-type and nanocomposite-based scaffolds improved tissue growth, cell differentiation, adhesion, and synthesis of cartilaginous extracellular matrix. To enhance bone regeneration for dental implants and mandibular bone defects, nanomaterials such as nanohydroxyapatite composite scaffolds, nanomodified mineral trioxide aggregate, and graphene were tested. Although the scientific knowledge in nanomaterials is rapidly advancing, there remain many unexplored data regarding their standardization, safety, and interactions with the nanoenvironment.

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Alveolar bone repair with strontium- containing nanostructured carbonated hydroxyapatite

Cited by 31 publications

References 24 publications

<p>High loads of nano-hydroxyapatite/graphene nanoribbon composites guided bone regeneration using an osteoporotic animal model</p>

<p>High loads of nano-hydroxyapatite/graphene nanoribbon composites guided bone regeneration using an osteoporotic animal model</p>

Evaluation of the In Vivo Biocompatibility of Amorphous Calcium Phosphate-Containing Metals

Nanomaterials in Craniofacial Tissue Regeneration: A Review

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