Alveolar Ridge Preservation Using Leukocyte and Platelet-Rich Fibrin: A Report of a Case

Peck, M.T.; Marnewick, Jeanine L.; Stephen, Lawrence

doi:10.1155/2011/345048

Cited by 34 publications

(26 citation statements)

References 10 publications

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“…The suitability of PRF as a biologically active scaffold has been illustrated in a number of studies revealing proliferation and differentiation of osteoblasts and gingival fibroblasts [8, 9]. Clinical studies have demonstrated that PRF promotes soft tissue and bone regeneration [10, 11], as well as periodontal tissue regeneration [12, 13]. The ability of PRF to augment and regenerate compromised tissues may be enhanced in combination with bone substitutes such as Bio-Oss or autologous bone [14, 15].…”

Section: Introductionmentioning

confidence: 99%

Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation

Pan

Dangaria³

et al. 2013

BioMed Research International

107

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In the present study we have determined the suitability of platelet-rich fibrin (PRF) as a complex scaffold for periodontal tissue regeneration. Replacing PRF with its major component fibrin increased mineralization in alveolar bone progenitors when compared to periodontal progenitors, suggesting that fibrin played a substantial role in PRF-induced osteogenic lineage differentiation. Moreover, there was a 3.6-fold increase in the early osteoblast transcription factor RUNX2 and a 3.1-fold reduction of the mineralization inhibitor MGP as a result of PRF application in alveolar bone progenitors, a trend not observed in periodontal progenitors. Subcutaneous implantation studies revealed that PRF readily integrated with surrounding tissues and was partially replaced with collagen fibers 2 weeks after implantation. Finally, clinical pilot studies in human patients documented an approximately 5 mm elevation of alveolar bone height in tandem with oral mucosal wound healing. Together, these studies suggest that PRF enhances osteogenic lineage differentiation of alveolar bone progenitors more than of periodontal progenitors by augmenting osteoblast differentiation, RUNX2 expression, and mineralized nodule formation via its principal component fibrin. They also document that PRF functions as a complex regenerative scaffold promoting both tissue-specific alveolar bone augmentation and surrounding periodontal soft tissue regeneration via progenitor-specific mechanisms.

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Section: Introductionmentioning

confidence: 99%

Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation

Pan

Dangaria³

et al. 2013

BioMed Research International

107

View full text Add to dashboard Cite

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“…The biomaterial acts by releasing high-concentration growth factors to the wound site, thereby stimulating healing and new bone formation [17]. Unlike other socket preservation procedures, the use of PRF is a simple method that requires minimal cost and reduces the need for grafting material.…”

Section: Discussionmentioning

confidence: 99%

Natural Tooth Pontic: An Instant Esthetic Option for Periodontally Compromised Teeth—A Case Series

Raj

Mehrotra

Narayan

et al. 2016

Case Reports in Dentistry

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Sudden tooth loss in the esthetic zone of the maxillary or mandibular anterior region can be due to trauma, periodontal disease, or endodontic failure. The treatment options for replacing the missing tooth can vary between removable prosthesis, tooth-supported prosthesis, and implant-supported prosthesis. Irrespective of the final treatment, the first line of management would be to provisionally restore the patient's esthetic appearance at the earliest, while functionally stabilizing the compromised arch. Using the patient's own natural tooth as a pontic offers the benefits of being the right size, shape, and color and provides exact repositioning in its original intraoral three-dimensional position. Additionally, using the patient's platelet concentrate (platelet rich fibrin) facilitates early wound healing and preservation of alveolar ridge shape following tooth extraction. The abutment teeth can also be preserved with minimal or no preparation, thus keeping the technique reversible, and can be completed at the chair side thereby avoiding laboratory costs. This helps the patient better tolerate the effect of tooth loss psychologically. The article describes a successful, immediate, and viable technique for rehabilitation of three different patients requiring replacement of a single periodontally compromised tooth in an esthetic region.

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“…Plusieurs études cliniques ont été menées afin de détermi-ner son potentiel clinique : -Peck et al proposent l'utilisation du PRF seul pour préserver la hauteur et l'épaisseur de l'os alvéolaire après une extraction [4]. Une partie de la membrane de PRF est découpée en plusieurs morceaux qui sont déposés dans l'alvéole, tandis que l'autre partie est posée contre l'os alvéolaire et recouverte par le lambeau muco-gingival.…”

Section: Discussionunclassified

Le PRF en implantologie dentaire : une technique prometteuse à Madagascar ?

Rakotoarison

Rakotoarivony

Rakotoarisoa³

et al. 2013

Med Buccale Chir Buccale

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Résumé -En odontologie, l'indication de la pose d'un implant peut être limitée par le volume du tissu osseux alvéolaire résiduel. La réalisation d'une greffe osseuse ou l'apport d'un matériau de substitution est parfois néces-saire. Le PRF (platelet-rich fibrin) est un concentré plaquettaire autogène utilisé pour stimuler la néoformation osseuse et favoriser la cicatrisation. C'est une préparation d'utilisation récente. L'intérêt de ce travail repose sur la gestion des tissus durs et des tissus mous en chirurgie pré-implantaire. Il se donne comme objectif de montrer l'intérêt clinique d'une technique de préparation simple en vue d'une régénération tissulaire en chirurgie orale, plus particulièrement en implantologie dentaire. Cette étude décrit la préparation du PRF et son utilisation. Il s'agit d'une préparation extemporanée, réalisée au « bloc opératoire odontologique » sur des patients en vue d'une pose d'implant. Du sang veineux est prélevé, mis dans des tubes sans anticoagulant et passé à la centrifugeuse à 3000 tours/mn pendant 10 mn pour obtenir un gel de PRF. Ce gel est pressé entre deux compresses stériles pour obtenir une membrane de PRF. Il est utilisé seul ou mélangé à de l'os autogène ou à un matériau de substitution et placé sous le lambeau, contre le tissu osseux résiduel. À Madagascar, l'implantologie dentaire s'est déve-loppée seulement depuis quelques années, et l'apport du PRF apparaît très prometteur. Toutefois, il doit être utilisé avec prudence car la littérature n'est pas unanime sur ses indications.Abstract -The PRF in dental implant: a promising technique in Madagascar.

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Alveolar Ridge Preservation Using Leukocyte and Platelet-Rich Fibrin: A Report of a Case

Cited by 34 publications

References 10 publications

Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation

Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation

Natural Tooth Pontic: An Instant Esthetic Option for Periodontally Compromised Teeth—A Case Series

Le PRF en implantologie dentaire : une technique prometteuse à Madagascar ?

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