Alveolar soft-part sarcoma of the neck

Silbergleit, Richard; Agrawal, Rajneesh; Savera, Adnan T.; Patel, Suresh

doi:10.1007/s00234-002-0776-0

Cited by 7 publications

(6 citation statements)

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“…The microscopic picture varies little from tumor to tumor, and this uniformity is one of its characteristic features 1, 3, 17. Differential diagnoses of ASPSs include tumors with large cells organized in nests with eosinophilic/clear cytoplasm, such as renal clear cell carcinomas, malignant melanomas, adrenal cortical carcinomas, hepatocellular carcinomas, and paragangliomas.…”

Section: Discussionmentioning

confidence: 99%

“…Alveolar soft-part sarcomas (ASPSs) are clinically and morphologically distinct soft-tissue sarcomas first defined and named by Christopherson et al in 1952 1 . ASPSs are rare, uniform malignant neoplasms with no benign counterpart that account for <1% of all soft-tissue sarcomas 1, 2, 3, 4, 5, 6, 7. Tumors are usually associated with muscle, but the histogenesis remains uncertain 2, 3, 8.…”

Section: Introductionmentioning

confidence: 99%

“…ASPSs are rare, uniform malignant neoplasms with no benign counterpart that account for <1% of all soft-tissue sarcomas 1, 2, 3, 4, 5, 6, 7. Tumors are usually associated with muscle, but the histogenesis remains uncertain 2, 3, 8. Most of the tumors occur in adolescents and young adults (age 15–30 years), and females are more often affected 5, 8.…”

Section: Introductionmentioning

confidence: 99%

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Alveolar soft-part sarcoma of the masseter and mandibular ramus: Report of a case and review of the literature

Martínez

Niklander

Deichler

et al. 2018

Journal of Dental Sciences

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Alveolar soft-part sarcomas are clinically and morphologically distinct soft-tissue sarcomas, with an unknown histogenesis. When the tumors affect the region of the head and neck, they are often located in the orbit and tongue. We report a case of an alveolar soft-part sarcoma in the left masseter of a 28-year-old female. The patient had chronic pain and paresthesia of her left lower lip. Panoramic radiography and computed tomography showed a well-delimited radiolucent mass in the left ramus. An incisional biopsy was performed, and the sample submitted for histopathological study. The tumor showed positive periodic acid-Schiff diastase-resistant granules. Immunohistochemically, the tumor cells were diffusely positive for myoglobin, and focally positive for actin and desmin.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alveolar soft-part sarcoma of the masseter and mandibular ramus: Report of a case and review of the literature

Martínez

Niklander

Deichler

et al. 2018

Journal of Dental Sciences

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“…On imaging, the tumor demonstrates low attenuation on noncontrast CT and strong tumor enhancement with contrast administration. TI- and T2-weighted MRI images typically show higher signal intensity than muscle while demonstrating tubular areas of flow voids, representative of rapid blood flow within the tumor [ 16 , 17 ]. Microscopically, ASPS is characterized by a pseudoalveolar appearance with clustered polygonal tumor cells, containing an abundant eosinophilic to clear granular cytoplasm, and separated by capillary-sized vascular channels and connective tissue [ 8 , 12 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Adult Alveolar Soft Part Sarcoma of the Head and Neck: A Report of Two Cases and Literature Review

Mullins

Hackman

2014

Case Reports in Oncological Medicine

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Background. Alveolar soft part sarcomas (ASPS) of the head and neck are rare, aggressive soft-tissue malignancies. This study describes the clinical course and management of two patients presenting with ASPS in very rare head and neck locations, the larynx and parotid gland. Methods. We identified two patients presenting with ASPS of the head and neck and treated at the University of North Carolina. We compared our results to the literature from 1987 to 2013. Results. Patient ages at diagnosis were 27 and 39 with presenting symptoms of hoarseness and parotid swelling, respectively. Mean follow-up was 87 months. All patients received surgical resection and adjuvant radiotherapy. There were no recurrences or evidence of distant metastatic spread during the series. Disease-free survival time for the patients was 4 months and 168 months, respectively. Conclusions. Our study suggests that a combined-modality approach is important in the treatment of ASPS of the head and neck even in these rare locations. Continued research into new therapies is necessary to improve historically poor outcomes.

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“…ten [3]. Der Tumor ist stark vaskularisiert, zeigt Pulsationen und führt in der Regel zu hörbaren Gefäßgeräuschen [1].…”

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Metastasiertes alveol�res Weichteilsarkom bei einer 26-j�hrigen Patientin

et al. 2004

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Alveolar soft-part sarcoma of the neck

Abstract: We report a case of alveolar soft-part sarcoma involving the posterior paraspinal musculature of the neck. This rare tumor of uncertain histogenesis typically occurs in the lower extremities in young adults and in the tongue or orbit in infants.

Cited by 7 publications

References 0 publications

Alveolar soft-part sarcoma of the masseter and mandibular ramus: Report of a case and review of the literature

Alveolar soft-part sarcoma of the masseter and mandibular ramus: Report of a case and review of the literature

Adult Alveolar Soft Part Sarcoma of the Head and Neck: A Report of Two Cases and Literature Review

Metastasiertes alveol�res Weichteilsarkom bei einer 26-j�hrigen Patientin

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