Ambergris: perfume e síntese

Tenius, Beatriz Soares Machado; Schroeder, E.; Schenato, Rossana Angelica

doi:10.1590/s0100-40422000000200013

Cited by 5 publications

(5 citation statements)

References 26 publications

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“…21,22 Drimenol can also be used as starting compound for (-)-ambrox, the most important equivalent of Ambergris, widely used in perfumery. 23,24 Additionally, it has been the starting material for nitrogenated drimane with guanidine moiety possessing antifungal activity 25 and the cytotoxic ent-cyclozonarone especially towards MS-1, mice endothelial cells. 26 These selected examples illustrate the importance of this secondary metabolite and moreover the necessity to identify new natural sources for this compound due to the restricted occurrence of D. winteri.…”

Section: Essential Oil Compositionmentioning

confidence: 99%

Chemical characterization of essential oils from Drimys angustifolia miers (Winteraceae) and antibacterial activity of their major compounds

Santos¹,

Dognini²,

Begnini³

et al. 2013

J. Braz. Chem. Soc.

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Nos últimos anos, os óleos essenciais vêm sendo intensamente estudados como fonte natural de novos agentes antimicrobianos. Neste trabalho, os óleos essenciais das folhas e galhos de Drimys angustifolia do sul do Brasil foram obtidos por hidrodestilação e analisados por cromatografias gasosas com detector de ionização de chama (GC-FID) e com espectrômetro de massa (GC-MS). Os constituintes drimenol e biciclogermacreno foram isolados por cromatografia em coluna do óleo essencial dos galhos e folhas, respectivamente. Os óleos, os constituintes isolados e combinações destes foram testados contra bactérias Gram-(+) e Gram-(-). Os óleos essenciais foram mais ativos contra Bacillus cereus, com MIC (concentração inibitória mínima) de 125 e 250 µg mL -1 para os galhos e folhas, respectivamente, inibindo fortemente o crescimento bacteriano. Biciclogermacreno foi mais ativo que drimenol, fornecendo um valor de MIC de 167 µg mL -1 contra B. cereus. Não foi observado qualquer efeito sinérgico nas combinações testadas.Essential oils have been extensively studied in recent years as a natural source of new antimicrobial agents. In this work, essential oils of leaf and branch from Drimys angustifolia growing in Southern Brazil were obtained by hydrodistillation and analyzed by gas chromatographies with flame ionization detector (GC-FID) and with mass spectrometer (GC-MS). Drimenol and bicyclogermacrene were isolated by column chromatography from branch and leaf essential oils, respectively. Oils, isolated compounds and combinations of them were assayed against Gram-(+) and Gram-(-) bacteria. The oils showed to be more active against Bacillus cereus, with minimum inhibitory concentration (MIC) 125 and 250 µg mL -1 for branch and leaf oils, respectively, strongly inhibiting bacterial growth. Bicyclogermacrene was more active then drimenol, providing a MIC value of 167 µg mL -1 against B. cereus. Synergism was not observed in any of the combinations tested.

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Section: Essential Oil Compositionmentioning

confidence: 99%

Chemical characterization of essential oils from Drimys angustifolia miers (Winteraceae) and antibacterial activity of their major compounds

Santos¹,

Dognini²,

Begnini³

et al. 2013

J. Braz. Chem. Soc.

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“…Odors are perceived by the Olfactory System 1 , and many theories relating to the type and quality of the molecular structures of the odors have been proposed. The most important are the steric theory of odor and the vibration theory of odor 2,3 .…”

Section: Aromamentioning

confidence: 99%

“…He speculated that the nose receptors responsible for sending each aroma signal to the brain, work as a system of the type "key-lock". The combination of the odor molecules of different structural forms (keys) with their specific receptors (locks) generate signals, which in turn are sent to the brain, and culminate with the perception of different aromas 2,3 .…”

Section: Aromamentioning

confidence: 99%

“…The vibration theory of odor initially proposed by Dyson, and later on by Wright, defends that such recognition and the similarities among the molecules of the aromas are related to their intramolecular vibration, rather than to their molecular shapes 2,3 . Keller & Vosshall using psychophysical methods in humans to test the vibration theory showed no evidence to support this theory, so the steric theory is the most accepted at present 4 .…”

Section: Aromamentioning

confidence: 99%

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The role of the Major Histocompatibility Complex in the Immunobiology of Self-Aromas

Magri

Araújo

2019

Rev Neurocienc

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The authors present a review of the immunobiological mechanism of olfaction considering current and relevant information about the odors released by vertebrate organisms, and its association with the immune system. Many theories concerning to the type and the quality of the molecular structures of odors or aromas have been proposed, but the most important are the steric theory of odor and the vibration theory of odor. Several techniques based on brain activities have been studied in association with sensorial processes, and they were particularly important to evaluate the physiologycal effects of odors. Molecules of the Major Histocompatibility Complex (MHC) have been identified in individual body odors (odortype), and volatile compounds of the MHC were easily detected in the urine of mice. The major relevant studies related to the Olfactory Receptors (ORs) and the MHC were conducted in mice models, and these studies demonstrated that the odortype has an important role in the partner choice, as well as in the relationship between mothers and their offsprings. A sensorial gas apparatus called “eletronic nose” has been used as an instrument capable of detecting molecules of the MHC in the odortypes. In conclusion, the diversity of self-aromas or odortypes seems to be generated in the context of the MHC, and consequently varies according to the genetic background of the individual. In spite of several controversies among scientists concerning to the immunobiology of the aromas, mostly in human beings, we could hypothesize that similar types of odors could influence the human choice. Future studies are necessary to clarify and confirm these findings in human beings.

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“…ex., óleo de copaíba 13 , café 14 , ambergris 15 , reações de ozonólise em fase gasosa 16 seguido de artigos em bebidas 17 e constituintes de plantas em geral.…”

Section: Produtos Naturais Voláteisunclassified