Ambient Aqueous Synthesis of Ultrasmall PEGylated Cu2−xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer

Zhang, Shaohua; Sun, Changzheng; Zeng, Jianfeng; Sun, Qiao; Wang, Guanglin; Wang, Yong; Wu, Yan; Dou, Shi Xue; Gao, Mingyuan; Li, Zhen

doi:10.1002/adma.201602193

Cited by 300 publications

(223 citation statements)

References 43 publications

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“…Compared to other conventional therapeutic techniques, PTT boasts many merits such as the simplicity, minimal invasiveness, low incidence of complications, as well as the high spatial and temporal precision of NIR light 8, 9, 10, 11. Various types of nanoagents have been explored to attain better PTT performance12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 and in the treatment, intravenous injection of the nanoagents (to mice, for example) is followed by high‐power NIR laser irradiation for ablation 25, 26, 27, 28, 29. Despite recent progress, clinical adoption of PTT still faces several hurdles.…”

Section: Introductionmentioning

confidence: 99%

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

et al. 2018

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Photothermal therapy (PTT) is a fledgling therapeutic strategy for cancer treatment with minimal invasiveness but clinical adoption has been stifled by concerns such as insufficient biodegradability of the PTT agents and lack of an efficient delivery system. Here, black phosphorus (BP) nanosheets are incorporated with a thermosensitive hydrogel [poly(d,l‐lactide)‐poly(ethylene glycol)‐poly(d,l‐lactide) (PDLLA‐PEG‐PDLLA: PLEL)] to produce a new PTT system for postoperative treatment of cancer. The BP@PLEL hydrogel exhibits excellent near infrared (NIR) photothermal performance and a rapid NIR‐induced sol–gel transition as well as good biodegradability and biocompatibility in vitro and in vivo. Based on these merits, an in vivo PTT postoperative treatment strategy is established. Under NIR irradiation, the sprayed BP@PLEL hydrogel enables rapid gelation forming a gelled membrane on wounds and offers high PTT efficacy to eliminate residual tumor tissues after tumor removal surgery. Furthermore, the good photothermal antibacterial performance prevents infection and this efficient and biodegradable PTT system is very promising in postoperative treatment of cancer.

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Section: Introductionmentioning

confidence: 99%

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

et al. 2018

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“…A lot of drug delivery systems have been developed to realize combination chemotherapy and photothermal ablation. For instance, chemical drugs were directly loaded in photothermal nanoparticles, such as gold,19, 20, 21, 22 sulfide,23, 24, 25, 26 graphene and graphene‐like materials,27, 28, 29, 30 Prussian blue;31, 32 or loaded in mesoporous silica, smart polymer, aptamer, and cleavable linkages etc. modified on the photothermal particles 33, 34.…”

Section: Introductionmentioning

confidence: 99%

NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy

Wang

Yang

et al. 2018

Advanced Science

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Construction of localized drug‐eluting systems with synergistic chemothermal tumor‐killing abilities is promising for biomedical implants directly contacting with tumor tissues. In this study, an intelligent and biocompatible drug‐loading platform, based on a gold nanorods‐modified butyrate‐inserted NiTi‐layered double hydroxides film (Au@LDH/B), is prepared on the surface of nitinol alloy. The prepared films function as drug‐loading “sponges,” which pump butyrate out under near‐infrared (NIR) irradiation and resorb drugs in water when the NIR laser is shut off. The stimuli‐responsive release of butyrate is verified to be related with the NIR‐triggered crystal phase transformation of Au@LDH/B. In vitro and in vivo studies reveal that the prepared films possess excellent biosafety and high efficiency in synergistic thermochemo tumor therapy, showing a promising application in the construction of localized stimuli‐responsive drug‐delivery systems.

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“…29,30 In addition to the potential use of ultrasmall selenide NPs in photoacoustic imaging (PAI) and photothermal therapy, the large X-ray attenuation coefficients of Se elements for low-energy X-rays (μ = 48.18 cm 2 g − 1 at 20 keV) highlight their potential in X-ray computed tomography (CT) imaging, whereas sulfides do not exhibit this beneficial effect. 31 These examples clearly illustrate the huge potential of selenide in chemo-/ radiotherapy and in multimodal imaging-guided synergistic therapy against cancer. Notably, the valence of selenium may not influence the treatment effect for cancer.…”

Section: Introductionmentioning

confidence: 99%

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

et al. 2017

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An efficient radiotherapeutic agent is synthesized using ultrathin two-dimensional 30-nm-wide and 2-nm-thick Bi 2 Se 3 nanosheets (NSs) as a radiosensitizer. Chitosan (CS) and RGD peptide are employed to enhance the radiotherapy efficiency and biocompatibility. The Bi 2 Se 3 -CS-RGD NSs exhibit excellent targeting ability to αvβ3 integrin-overexpressing cancer cells and potent radiosensitization efficiency with high stability. Detailed in vitro experiments show that the Bi 2 Se 3 -CS-RGD NSs enhance the sensitivity of HeLa cells to X-ray-induced cell death by inhibiting TrxR activities and activating downstream reactive oxygen species-mediated signaling pathways. In vivo experiments using intravenous or intratumor injection demonstrate that the Bi 2 Se 3 -CS-RGD NSs are more efficient tumor growth inhibitors compared to bare Bi 2 Se 3 NSs. The multifunctionality of the NSs enables the use of photoacoustic imaging and magnetic resonance imaging to examine their targeting ability and therapeutic effects, respectively. In addition, the RGD-decorated Bi 2 Se 3 NSs show much better in vivo biocompatibility and can be efficiently expelled from the body after 48 h post injection. This study reveals an effective and safe theranostic agent for next-generation cancer radiotherapy.

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Ambient Aqueous Synthesis of Ultrasmall PEGylated Cu₂₋_xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer

Cited by 300 publications

References 43 publications

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

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