Ambient temperature and infarct size, microvascular obstruction, left ventricular function and clinical outcomes after ST-segment elevation myocardial infarction

Redfors, Björn; Simonato, Matheus; Chen, Shmuel; Vincent, Flavien; Zhang, Zixuan; Thiele, Holger; Eitel, Ingo; Patel, Manesh R.; Ohman, E. Magnus; Maehara, Akiko; Ben‐Yehuda, Ori; Stone, Gregg W.

doi:10.1097/mca.0000000000001099

Cited by 5 publications

(5 citation statements)

References 47 publications

(63 reference statements)

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“… 95 Furthermore, cold spells during pregnancy have been linked to increased incidence of congenital artic coarctation, 96 while temperature extremes may be associated with increased symptoms of hypertrophic cardiomyopathy 97 and with lower left ventricular ejection fraction after myocardial infarction. 98 All of these conditions are recognized causes 99 , 100 of Group 2 PH.…”

Section: Direct and Indirect Impact Of Climate Change On Pvdmentioning

confidence: 99%

“…Air pollution not only increases the incidence of LHD, 47 but preliminary animal studies have found a worsening of PH in a left ventricle failure mouse model (through transverse aortic constriction) when exposed to PM 2.5 , 30,31 and a MESA study found greater left ventricular mass in subjects exposed to higher air pollution 95 . Furthermore, cold spells during pregnancy have been linked to increased incidence of congenital artic coarctation, 96 while temperature extremes may be associated with increased symptoms of hypertrophic cardiomyopathy 97 and with lower left ventricular ejection fraction after myocardial infarction 98 . All of these conditions are recognized causes 99,100 of Group 2 PH.…”

Section: Direct and Indirect Impact Of Climate Change On Pvdmentioning

confidence: 99%

“…95 Cold spells ↑ incidence of aortic coarctation 96 ; extreme temperatures linked to ↑ symptoms in hypertrophic cardiomyopathy 97 and ↓ LV function after acute myocardial infarction. 98 Group 3 PH COPD Air pollution is main risk factor for COPD in nonsmokers 48 and linked to ↑ incidence of COPD 50 and ↑severity of emphysema. 49 ↑mortality risk, 51,52 ↑ symptoms, 54 ↑exacerbations, 54,57,58 ↑hospitalisations 55,56 and ↓lung function 54 with extreme high and low temperatures and dust exposure.…”

Section: Portopulmonary Hypertensionmentioning

confidence: 99%

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Pulmonary vascular disease, environmental pollution, and climate change

Lichtblau,

Reimann,

Piccari

2024

Pulm. circ.

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Pollution and climate change constitute a combined, grave and pervasive threat to humans and to the life‐support systems on which they depend. Evidence shows a strong association between pollution and climate change on cardiovascular and respiratory diseases, and pulmonary vascular disease (PVD) is no exception. An increasing number of studies has documented the impact of environmental pollution and extreme temperatures on pulmonary circulation and the right heart, on the severity and outcomes of patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (PH), on the incidence of pulmonary embolism, and the prevalence and severity of diseases associated with PH. Furthermore, the downstream consequences of climate change impair health care systems' accessibility, which could pose unique obstacles in the case of PVD patients, who require a complex and sophisticated network of health interventions. Patients, caretakers and health care professionals should thus be included in the design of policies aimed at adaptation to and mitigation of current challenges, and prevention of further climate change. The purpose of this review is to summarize the available evidence concerning the impact of environmental pollution and climate change on the pulmonary circulation, and to propose measures at the individual, healthcare and community levels directed at protecting patients with PVD.

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Section: Direct and Indirect Impact Of Climate Change On Pvdmentioning

confidence: 99%

Section: Direct and Indirect Impact Of Climate Change On Pvdmentioning

confidence: 99%

Section: Portopulmonary Hypertensionmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary vascular disease, environmental pollution, and climate change

Lichtblau,

Reimann,

Piccari

2024

Pulm. circ.

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“… 10 , 11 Redfors et al showed that extreme temperatures were related to larger infarct size and smaller left ventricular ejection fraction in patients with ST-segment elevation myocardial infarction. 12 Hensel et al reported that even in moderate climatic conditions, low temperatures can still lead to an increased frequency of CAD, especially below 10 °C. 13 A time-series analysis study based on major cities across China found that the mortality risk and burden from main cardiopulmonary diseases was more pronounced in temperate monsoon and subtropical monsoon climatic zones.…”

Section: Introductionmentioning

confidence: 99%

Effects of Daily Mean Temperature on Daily Hospital Admissions for Coronary Artery Disease: A Retrospective Study

Wang,

Lin,

Chen

et al. 2024

RMHP

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Purpose Temperature changes unfavorably impact on cardiovascular disease. However, the association between temperature changes and coronary artery disease (CAD) is not well documented. This study aimed to explore the association between daily mean temperature and daily CAD hospital admissions on the southeast coast of China (Fuzhou City). Methods A total of 1883 CAD patients who underwent percutaneous coronary intervention between 2017 and 2019 were obtained. The severity of CAD was evaluated by the Gensini score. Distributed lag non-linear model (DLNM) combined with a quasi-Poisson regression model was used to examine the delayed effect between daily mean temperature and daily CAD hospital admissions. Stratified analyses were performed by Gensini score and severity of lesions. The relative risk (RR) with a 95% confidence interval (CI) was used to assess the relationship. Results Extreme cold (8°C) (RR=0.49, 95% CI: 0.25–0.99) and moderate cold (10°C) (RR=0.56, 95% CI: 0.31–0.99) daily mean temperature with a lag of 0–20 days were correlated with lower risk of daily CAD hospital admissions. Moderate heat (30°C) (RR=1.80, 95% CI: 1.01–3.20) and extreme heat (32°C) (RR=2.02, 95% CI: 1.01–4.04) daily mean temperature with a lag of 0–20 days related to a higher risk of daily CAD hospital admissions. Similar results were observed for daily mean temperature with a lag of 0–25 days. Stratified analysis showed the lagged effect of daily mean temperature (lag 0, 0–5, 0–15, 0–20, and 0–25 days) on the daily CAD hospital admissions was observed only in patients with a Gensini score ≤39 (tertile 1). Conclusion Cold temperatures may have a protective effect on daily CAD hospital admissions in the Fuzhou area, whereas hot temperatures can have an adverse effect.

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“…In addition, some studies have shown that improving the utilization of fatty acids and sugars is an effective means to treat heart failure after myocardial infarction. In recent years, scholars from China and other countries have discussed the changes of small molecule metabolite content, aiming to explore the pathogenesis of heart failure and find new therapeutic targets (Redfors et al, 2021). Amino acids play a vital role in human vitality and biosynthesis.…”

Section: Introductionmentioning

confidence: 99%

Expression of miR-320 and miR-204 in myocardial infarction and correlation with prognosis and degree of heart failure

et al. 2023

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Myocardial infarction is a very dangerous cardiovascular disease with a high mortality rate under the modern developed medical technology. miRNA is a small molecule regulatory RNA discovered in recent years, which can play an important role in many cancers and other diseases. Medical data, machine learning and medical care strategies supporting the Internet of Things (IoMT) have certain applications in the treatment of myocardial infarction. However, the specific pathogenesis of myocardial infarction is still unclear. Therefore, this paper aimed to explore the expression of microRNA-320 and microRNA-204 in myocardial infarction and used the expression of microRNA-320 and microRNA-204 to predict the prognosis of patients with myocardial infarction. In order to discuss the expression of microRNA-320 and microRNA-204 in myocardial infarction in more detail. In this paper, 40 patients in the trial period were selected for clinical research, and 10 patients with normal cardiac function were selected in NHF group as control group. 10 patients with heart failure were selected as AMHF group. 10 patients with acute myocardial infarction were selected as AMNHF group. 10 patients with heart failure after old myocardial infarction were selected as OMHF group. AMHF group, AMNHF group and OMHF group were taken as the case group. This paper analyzed the difference of miR between different groups and determined that there were significant differences in the expression of miR-320 and miR-204 between different groups. Finally, the expression and prognosis of miR-320 and miR-204 in myocardial infarction were analyzed. The analysis results showed that the expression of microRNA-320 and microRNA-204 can inhibit the activity of myocardial cells. On the fifth day, the corresponding expression of microRNA-320 and microRNA-204 reduced the optical density of myocardial cells to 1.75 and 1.76, which was significantly lower than that on the first day. Moreover, excessive miR-320 expression and excessive miR-204 expression can increase the apoptosis rate of myocardial cells. The above results indicated that the high expression of microRNA-320 and microRNA-204 can be a bad prognostic factor in patients with myocardial infarction, showing that medical data, machine learning and medical care strategies supporting IoMT can play a role in the treatment of myocardial infarction. Therefore, it is urgent to understand the pathogenesis of heart failure after myocardial infarction and find new treatment schemes to improve the positive prognosis.

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Ambient temperature and infarct size, microvascular obstruction, left ventricular function and clinical outcomes after ST-segment elevation myocardial infarction

Abstract: Participating studies, inclusion criteria and definitionsAs previously described [15], the present study represents an academic collaboration between the principal

Cited by 5 publications

References 47 publications

Pulmonary vascular disease, environmental pollution, and climate change

Pulmonary vascular disease, environmental pollution, and climate change

Effects of Daily Mean Temperature on Daily Hospital Admissions for Coronary Artery Disease: A Retrospective Study

Expression of miR-320 and miR-204 in myocardial infarction and correlation with prognosis and degree of heart failure

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