Ambulatory Blood Pressure in Children Followed for 3 Years: Influence of Sex and Family History of Hypertension

Eiff, A. W. v.; Gogolin, E; Jacobs, U.; Neus, H.

doi:10.3109/10641968609046575

Cited by 17 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evidence from a number of sources has suggested that mechanisms of blood pressure homeostasis might be quite different for males and females (40,41). For example, in several models of hypertension, elevated blood pressure develops sooner and is more severe in males than females (42).…”

Section: Discussionmentioning

confidence: 99%

The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure

Stock¹,

Shinjo²,

Burkhardt³

et al. 2001

J. Clin. Invest.

212

142

View full text Add to dashboard Cite

IntroductionProstaglandin E2 (PGE 2 ) is produced during inflammatory responses, and increased levels of PGE 2 help mediate some of the cardinal features of inflammation, including pain, edema, and fever (1, 2). PGE 2 exerts its effects through interactions with EP receptors, termed EP1-4 (3). Nonsteroidal anti-inflammatory drugs (NSAIDs) act by inhibiting cyclooxygenase (COX) enzymes and thereby inhibiting prostaglandin production. In the context of this putative mechanism of action, direct cause-and-effect relationships between interruption of specific receptor-mediated signaling pathways and therapeutic actions have not been firmly established. While NSAIDs are effective analgesic agents, certain NSAIDs have a number of troublesome side effects that are due in part to their broad inhibition of a variety of COX products (4,5).Defining the molecular mechanisms underlying both the therapeutic and adverse actions of NSAIDs should provide useful targets for new, more specific therapeutic strategies. Therefore, we focused on a receptor for one of the prostaglandins (PGE 2 ), the EP1 receptor (6). We generated EP1-deficient mice by gene targeting and compared their physiological responses to genetically matched wild-type controls. We find that EP1 -/-animals have reduced nociceptive pain perception as well as altered cardiovascular homeostasis. These results demonstrate the critical actions of EP1 receptors in two physiological functions: pain perception and blood pressure regulation. Methods EP1 targeting vector construction and production of EP1 -/-mice.Mouse genomic clones containing Ptgerep1, mouse gene symbol for EP1 receptor, were isolated from a DBA/1lacJ genomic λ-phage library (Stratagene, La Jolla, California, USA). Long-template PCR was used to amplify 5′and 3′ fragments of the clone using T3 or T7 and EP1-specific primers. A 4.5-kb 5′ fragment and 6.0-kb 3′ fragment were cloned into pCRII vector (Invitrogen Corp., San Diego, California, USA). These fragments were sequence confirmed and subcloned into pHok, a plasmid containing PGK-neo and PGK-thymidine kinase cassettes. The EP1 targeting vector was designed to replace 671 bp of coding sequence with the PGK-neo cassette. This 671-bp coding region was Received for publication March 9, 1999, and accepted in revised form December 6, 2000.The lipid mediator prostaglandin E2 (PGE 2 ) has diverse biological activity in a variety of tissues. Four different receptor subtypes (EP1-4) mediate these wide-ranging effects. The EP-receptor subtypes differ in tissue distribution, ligand-binding affinity, and coupling to intracellular signaling pathways. To identify the physiological roles for one of these receptors, the EP1 receptor, we generated EP1-deficient (EP1 -/-) mice using homologous recombination in embryonic stem cells derived from the DBA/1lacJ strain of mice. The EP1 -/-mice are healthy and fertile, without any overt physical defects. However, their pain-sensitivity responses, tested in two acute prostaglandin-dependent models, were reduced by approximately ...

show abstract

Section: Discussionmentioning

confidence: 99%

The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure

Stock¹,

Shinjo²,

Burkhardt³

et al. 2001

J. Clin. Invest.

212

142

View full text Add to dashboard Cite

show abstract

“…[11][12][13] The Hypertension in Pregnancy Offspring Study showed that mothers with gestational hypertension and with sustained postpartum hypertension (for 7-12 years following birth) have hypertensive children at greater frequency than mothers with gestational hypertension but no postpartum hypertension. 14 These findings strongly suggest that cardiovascular risk factors (CVRFs) could emerge before adolescence in offspring of hypertensive subjects.…”

mentioning

confidence: 99%

Family History of Hypertension and Cardiovascular Risk Factors in Prepubertal Children

Rodrı́guez-Morán

Aradillas‐García

Simental‐Mendía

et al. 2010

American Journal of Hypertension

View full text Add to dashboard Cite

show abstract

“…As with most measurements in pediatrics, normal values for ABPM must be adjusted for body size (as a surrogate for maturational age) 92 and gender. 106 Where sufficient data are available, evaluation specific for race or ethnic differences should be performed. 107,108 Unfortunately, only limited large population-based cross-sectional studies have been performed using ABPM in healthy children, and few have truly proportional representation across age, race, body size, and gender.…”

Section: Distribution Of Bp Values On the Basis Of Abpm Normative Datmentioning

confidence: 99%

Ambulatory Blood Pressure Monitoring in Children and Adolescents: Recommendations for Standard Assessment

Urbina¹,

Alpert

Flynn³

et al. 2008

Hypertension

478

255

View full text Add to dashboard Cite

Ambulatory Blood Pressure in Children Followed for 3 Years: Influence of Sex and Family History of Hypertension

Cited by 17 publications

References 3 publications

The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure

The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure

Family History of Hypertension and Cardiovascular Risk Factors in Prepubertal Children

Ambulatory Blood Pressure Monitoring in Children and Adolescents: Recommendations for Standard Assessment

Contact Info

Product

Resources

About