Ameliorating effect of melatonin on mercuric chloride-induced neurotoxicity in rats

Said, Eman S.; Ahmed, Radwa M.; Mohammed, Rehab Ahmed; Morsi, Enas; Elmahdi, Mohamed; El‐Sayed, Hassan; Taha, Rania H.; Nadwa, Eman Hassan

doi:10.1016/j.heliyon.2021.e07485

Cited by 12 publications

(5 citation statements)

References 32 publications

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“…Melatonin is an important endogenous hormone secreted by the pineal gland [ 16 ]. Numerous studies have shown that exogenous melatonin could antagonize mercury-induced neurotoxicity [ 19 , 20 , 21 ]. To date, however, the effect of MeHg on endogenous melatonin secretion is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…It is a powerful endogenous antioxidant that is effective in preventing oxidative-stress-induced cellular oxidative damage [ 18 ]. Importantly, melatonin, when synthesized under physiological conditions with a circadian rhythm, has been shown to have a protective effect regarding mercury-induced CNS damage [ 19 , 20 , 21 ]. Therefore, it is significant to investigate the potential impact of MeHg on endogenous melatonin secretion for the prevention and treatment of MeHg-induced CNS damage.…”

Section: Introductionmentioning

confidence: 99%

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Subchronic Low-Dose Methylmercury Exposure Accelerated Cerebral Telomere Shortening in Relevant with Declined Urinary aMT6s Level in Rats

Tao

et al. 2023

Toxics

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Methylmercury (MeHg) is a global pollutant with established toxic effects on the central nervous system (CNS). However, early events and early-warning biomarkers of CNS damage following exposure to low-dose MeHg are still lacking. This study aimed to investigate whether subchronic low-dose MeHg exposure had adverse effects on the cerebral telomere length, as well as serum melatonin and its urinary metabolite 6-sulfatoxymelatonin (aMT6s) in rats. Sixteen male Sprague Dawley rats were divided into two groups. Group I was the control group. In group II, rats were exposed to MeHg by gavage at a dose of 0.1 mg/kg/day for 3 months. This study revealed that MeHg exposure resulted in impairment of learning and memory ability, a slightly reduced number of neurons and an irregular arrangement of neurons in the hippocampus. It also significantly accelerated telomere shortening in the cerebral cortex, hippocampus and hypothalamus. Moreover, MeHg exposure decreased the levels of melatonin in serum and aMT6s in urine, partly by suppressing the synthesis of 5-hydroxytryptamine (5-HT) in the brain but promoted the expression of melatonin-catalyzing AANAT and ASMT. Importantly, cerebral telomere length was positively correlated with MT and aMT6s after MeHg exposure. These results suggested that the shortened telomere length in the brain may be an early event in MeHg-induced CNS toxicity, and the level of aMT6s in urine may serve as an early-warning biomarker for MeHg-induced CNS damage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Subchronic Low-Dose Methylmercury Exposure Accelerated Cerebral Telomere Shortening in Relevant with Declined Urinary aMT6s Level in Rats

Tao

et al. 2023

Toxics

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“…(2017) indicated that mercuric chloride induces an increase in vascular endothelial growth factor expression level in brain tissue that promotes neuronal and blood-brain barrier (BBB) damage by allowing non-selective influx of cytotoxic and inflammatory cells from the blood into brain tissue. Mercuric chloride caused significant neurodegenerative changes in the form of rough endoplasmic reticulum fragmentation, Golgi apparatus ballooning, and nuclear and cytoplasmic degeneration of pyramidal neurons in the rat cerebral cortex ( Said et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Amelioration of mercuric chloride-induced physiologic and histopathologic alterations in rats using vitamin E and zinc chloride supplement

Shalan

2022

Heliyon

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“…Group HD: Received mercuric chloride (HgCl2) with i.p. injection at dose 1 mg/kg, (Said et al, 2021;Shalan 2022). Group RH: Received mercuric chloride and Resveratrol (HgCl2+ RES).…”

Section: Animal Groupingmentioning

confidence: 99%

“…HgCl2 solution is made in the following way. 100 mg of mercury chloride was dissolved in 100 ml of distilled water and the dose was 1µg.1µl -1 /1g of body weight (Said et al, 2021;Sheta et al, 2022).…”

Section: Preparation Of Hgcl2mentioning

confidence: 99%

Deleterious Effects of Mercuric Chloride Toxicity Initiated Partially from Physiological Disorder of Kidney, Immunocytes and Redox System, can be Reversed by Resveratrol Administration

Dawood,

Alghetaa

2023

AAVS

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This study is designed to highlight some of the physiological disorders taken place in the renal function, immunological response as well as the ability of the redox system represented by total antioxidant capacity and malondialdehyde levels to combat the toxic exposure of mercuric chloride (HgCl2) with or without collaboration of resveratrol (RES) supplement. Forty-five adult Sprague Dawley, 8-10 weeks old female rats weighing 170-220 g were randomly grouped as following; control group (C) kept without any medication. Dimethyl sulfoxide (DMSO) used as vehicle to prepare RES treatment was given to D-group. RES administered to R-group. Challenge group of rats (HD) was administered HgCl2. The last group of rats (HR) was given HgCl2 with RES in the same doses mentioned earlier. All treatments lasted for four weeks. At the termination of the experiment, blood samples were collected to evaluate the renal function as well as to evaluate the redox system activity. Furthermore, peritoneal exudate was collected to determine the population of infiltrating cells by using trypan blue dye. Analyzed data revealed that there was renal dysfunction represented by significant (P<0.05) increase in blood urea of HD and HR groups in comparison with control group. Total antioxidants were significantly (P<0.05) higher in the blood of HR group than all others. Moreover, peritoneal exudate showed significant (P<0.05) exacerbation of immunocyte counts in HgCl2-administered groups in comparison with others. However, resveratrol administration to HR group drove the inflammatory cell counts to be significantly (P<0.05) lower than of HD group. Altogether, we can conclude that the resveratrol has the required biological effects to support the body responses against deleterious consequences of mercuric chloride poisoning.

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Ameliorating effect of melatonin on mercuric chloride-induced neurotoxicity in rats

Cited by 12 publications

References 32 publications

Subchronic Low-Dose Methylmercury Exposure Accelerated Cerebral Telomere Shortening in Relevant with Declined Urinary aMT6s Level in Rats

Subchronic Low-Dose Methylmercury Exposure Accelerated Cerebral Telomere Shortening in Relevant with Declined Urinary aMT6s Level in Rats

Amelioration of mercuric chloride-induced physiologic and histopathologic alterations in rats using vitamin E and zinc chloride supplement

Deleterious Effects of Mercuric Chloride Toxicity Initiated Partially from Physiological Disorder of Kidney, Immunocytes and Redox System, can be Reversed by Resveratrol Administration

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