2020
DOI: 10.3389/fmicb.2020.567060
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Amelioration of Androgenetic Alopecia by Algal Oligosaccharides Prepared by Deep-Sea Bacterium Biodegradation

Abstract: Androgenetic alopecia (AGA) is a dihydrotestosterone (DHT)-mediated hair loss disorder characterized by shortened anagen hair cycle. Oligosaccharides derived from seaweeds possess diverse biological functions. However, little is known about their effects on AGA. In this study, algal oligosaccharide (AOS) was characterized for its mitigation effects on key features involved in AGA pathogenesis, such as DHT- mediated cellular signaling and shortened anagen hair cycle. AOS with varying degrees of polymerization (… Show more

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Cited by 12 publications
(7 citation statements)
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References 39 publications
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“…DHT was used to induce cell injured model similar to the previous study [ 41 ]. Briefly, HHDPCs (1 × 10 3 cells per well) were seeded on 96-well culture plates.…”
Section: Methodsmentioning
confidence: 99%
“…DHT was used to induce cell injured model similar to the previous study [ 41 ]. Briefly, HHDPCs (1 × 10 3 cells per well) were seeded on 96-well culture plates.…”
Section: Methodsmentioning
confidence: 99%
“…Furthermore, androgenetic alopecia has the characteristics of hair follicle miniaturization and hair cycle shortening 39 . It is possible that the incidence of hair graying may be higher than that in the normal population due to the faster follicle cycle switching such as androgenetic alopecia and trichotillomania 40,41 …”
Section: Mscs and Hair Grayingmentioning
confidence: 99%
“…39 It is possible that the incidence of hair graying may be higher than that in the normal population due to the faster follicle cycle switching such as androgenetic alopecia and trichotillomania. 40,41…”
Section: Unbalanced Hair Follicle Cyclementioning
confidence: 99%
“…These pathways generate various natural products with unique structures, great diversity, and significant biological activities ( Zhang et al, 2021 ). Jin et al (2020) used AGAR biodegradation bacteria Flammeovirga pacifica WPAGA1 isolated from deep-sea locations to prepare algal oligosaccharide (AOS). AOS inhibited dihydrotrophil (DHT) to prolong the hair growth period of mice and might be used to prevent androgenetic alopecia (AGA).…”
Section: Othersmentioning
confidence: 99%