Amelioration of hyperglycemia by Rubus occidentalis (black raspberry) and increase in short-chain fatty acids producing bacteria

Lee, Heetae; Kim, Jiyeon; An, Jinho; Lee, Sung-Won; Kong, Hyunseok; Song, Youngcheon; Choi, Hye Ran; Lee, Su Jung; Chae, Kyu Seo; Kwon, Ji Wung; Kim, Kyungjae

doi:10.1016/j.jff.2019.01.045

Cited by 22 publications

(20 citation statements)

References 45 publications

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“…RB intake also increased gut Lactobacillus , which is a healthy gut marker, and increased beneficial gut intestinal SCFAs, which are colonic epithelial cell substrates and improve gut health [ 78 ]. RB consumption increased SCFA-producing bacterial populations including Bacteroides , Butyricimonas , Ruminococcus, Akkermansia, Clostridium butyricum, Mucispirillum, Oscillibacter, Ruminococcaceae, and Lachnospiraceae, which improved metabolic syndromic conditions during metformin T2DM treatment [ 268 ]. Furthermore, RB consumption time- and dose-dependently increased the gut microbial population of Anaerostipes , Ruminococcus , Akkermansia , Coprobacillus , Allobaculum , Anaerovorax , Dorea , Asaccharobacter , Anaerotruncus , Coprobacillus , Desulfovibrio , Victivallis , and Mucispirilum, and decreased the microbial population of Acetivibrio , Anaerotruncus , Bifidobacterium , Lactococcus , Prabacteroides , Streptococcus , Turicibacter , and Acetivibrio .…”

Section: Raspberriesmentioning

confidence: 99%

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

et al. 2020

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Berries are considered “promising functional fruits” due to their distinct and ubiquitous therapeutic contents of anthocyanins, proanthocyanidins, phenolic acids, flavonoids, flavanols, alkaloids, polysaccharides, hydroxycinnamic, ellagic acid derivatives, and organic acids. These polyphenols are part of berries and the human diet, and evidence suggests that their intake is associated with a reduced risk or the reversal of metabolic pathophysiologies related to diabetes, obesity, oxidative stress, inflammation, and hypertension. This work reviewed and summarized both clinical and non-clinical findings that the consumption of berries, berry extracts, purified compounds, juices, jams, jellies, and other berry byproducts aided in the prevention and or otherwise management of type 2 diabetes mellitus (T2DM) and related complications. The integration of berries and berries-derived byproducts into high-carbohydrate (HCD) and high-fat (HFD) diets, also reversed/reduced the HCD/HFD-induced alterations in glucose metabolism-related pathways, and markers of oxidative stress, inflammation, and lipid oxidation in healthy/obese/diabetic subjects. The berry polyphenols also modulate the intestinal microflora ecology by opposing the diabetic and obesity rendered symbolic reduction of Bacteroidetes/Firmicutes ratio, intestinal mucosal barrier dysfunction-restoring bacteria, short-chain fatty acids, and organic acid producing microflora. All studies proposed a number of potential mechanisms of action of respective berry bioactive compounds, although further mechanistic and molecular studies are warranted. The metabolic profiling of each berry is also included to provide up-to-date information regarding the potential anti-oxidative/antidiabetic constituents of each berry.

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Section: Raspberriesmentioning

confidence: 99%

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

et al. 2020

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“…Alternatively, the potential use of dietary plants and their bioactive compounds has attracted recent interest, as these may act as possible sources of more potent and safer therapies for the improvement of hepatic insulin resistance. Considerable research has focused on berries owing to their high content of phenolic compounds, such as anthocyanins, flavonoids, and phenolic acid, which contribute to their relatively high antioxidant activity and exert beneficial effects on the reduction of hepatic insulin resistance (Lee et al., 2019). For example, the pea‐sized, violet‐black fruits of Aronia melanocarpa (Michx.)…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats

Xin

Zhang

et al. 2020

Journal of Food Science

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We aimed to investigate) the effects of Aronia melanocarpa berry extract (AMBE) on hepatic insulin resistance and its mechanism at the molecular level in high-fat diet (HFD)-and streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) rats. The rats were supplemented with AMBE at doses of 100 and 400 mg/kg body weight (bw) daily for 8 weeks. AMBE significantly reduced blood glucose and serum insulin levels and the homeostatic model assessment for insulin resistance score; improved glucose tolerance; increased hepatic glycogen content; and regulated glucose metabolism enzyme activity, including glucokinase, pyruvate kinase, phosphoenolpyruvate carboxykinase, and glucose-6-phosphatase in the liver. AMBE also reduced lipid accumulation and oxidative stress along with inflammation in the hepatic tissue of T2DM rats and improved hepatic function. The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was activated by AMBE through the elevation of insulin receptor substrate-2, PI3K, Akt, and glycogen synthase kinase-3β phosphorylation and glucose transporter 2, which might contribute to the promotion of glycogen synthesis and improvement of hepatic insulin resistance. AMBE shows promise as an ingredient of functional foods for alleviating hepatic insulin resistance in T2DM.Keywords: Aronia melanocarpa berry, hepatic insulin resistance, PI3K/Akt signaling pathway, type 2 diabetes mellitus Practical Application: The extract from the berries of Aronia melanocarpa (Michx.) Elliott (AMBE), with its relatively high content of polyphenolic compounds, has been shown to exert hypoglycemic effects in animal models of diabetes. Our findings support the use of A. melanocarpa as a functional food additive for the alleviation of hepatic insulin resistance and the management of glucose homeostasis in T2DM.

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“…Thirty-two studies reported changes in energy/food intake, among which three studies that used pure phenolic compounds (PPC) [ 35 , 40 , 42 , 43 ] and two [ 68 , 78 ] studies that investigated phenolic extracts (PE) reported a significant drop in energy/food intake compared to HFD. Significantly higher food consumption was recorded in three studies [2-PPC [ 41 , 50 ], 1-PE [ 73 ], while 24 studies reported non-significant difference in energy/food intake [ 45 , 46 , 47 , 51 , 52 , 57 , 59 , 60 , 62 , 63 , 66 , 74 , 75 , 80 ] ( Figure S4 ). As for bodyweight, thirty studies (67%) recorded a significant drop post-treatment, of which 16 with PPC [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 50 , 52 , 53 , 54 , 56 , 57 ], and 15 with PE [ 60 , 61 , 63 , 65 , 66 , 68 , 71 , 72 ,…”

Section: Resultsmentioning

confidence: 99%

“…As for bodyweight, thirty studies (67%) recorded a significant drop post-treatment, of which 16 with PPC [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 50 , 52 , 53 , 54 , 56 , 57 ], and 15 with PE [ 60 , 61 , 63 , 65 , 66 , 68 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 81 ]. Non-significant observations were made in 19 studies [11-PPC [ 37 , 38 , 44 , 46 , 47 , 48 , 49 , 51 , 55 , 58 ], 9-PE [ 59 , 60 , 62 , 64 , 65 , 67 , 69 , 70 , 80 ]] ( Figure S4 ).…”

Section: Resultsmentioning

confidence: 99%

“…Twelve studies reported non-significant changes in FG [ 35 , 38 , 50 , 55 , 62 , 64 , 65 , 66 , 68 , 70 , 73 , 77 ]. The oral/intraperitoneal glucose tolerance test (GTT) was evaluated in 21 studies, and among these, five PPC [ 41 , 42 , 43 , 47 , 53 , 57 ] and nine PE [ 59 , 60 , 61 , 62 , 64 , 67 , 72 , 76 , 77 ] showed significant improvement in glucose tolerance, and 12 studies reported non-significant changes [ 48 , 51 , 55 , 59 , 60 , 62 , 64 , 67 , 68 , 69 , 70 , 80 ]. Fasting insulin (FI) was significantly lowered in four studies with the use of PPC [ 39 , 42 , 43 , 48 , 54 ] and six studies with PE [ 65 , 66 , 68 , 70 , 72 , 77 ].…”

Section: Resultsmentioning

confidence: 99%

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Polyphenols as Prebiotics in the Management of High-Fat Diet-Induced Obesity: A Systematic Review of Animal Studies

Moorthy

Sundralingam

Palanisamy

2021

Foods

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Obesity is a disease growing at an alarming rate and numerous preclinical studies have proven the role of polyphenols in managing this disease. This systematic review explores the prebiotic effect of polyphenols in the management of obesity among animals fed on a high-fat diet. A literature search was carried out in PubMed, Scopus, CINAHL, Web of Science, and Embase databases following the PRISMA guidelines. Forty-four studies reported a significant reduction in obesity-related parameters. Most notably, 83% of the studies showed a decrease in either body weight/visceral adiposity/plasma triacylglyceride. Furthermore, 42 studies reported a significant improvement in gut microbiota (GM), significantly affecting the genera Akkermansia, Bacteroides, Blautia, Roseburia, Bifidobacteria, Lactobacillus, Alistipes, and Desulfovibrio. Polyphenols’ anti-obesity, anti-hyperglycaemic, and anti-inflammatory properties were associated with their ability to modulate GM. This review supports the notion of polyphenols as effective prebiotics in ameliorating HFD-induced metabolic derangements in animal models.

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Amelioration of hyperglycemia by Rubus occidentalis (black raspberry) and increase in short-chain fatty acids producing bacteria

Cited by 22 publications

References 45 publications

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats

Polyphenols as Prebiotics in the Management of High-Fat Diet-Induced Obesity: A Systematic Review of Animal Studies

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