Ameliorative Effect of Mannuronate Oligosaccharides on Hyperuricemic Mice via Promoting Uric Acid Excretion and Modulating Gut Microbiota

Abstract

Mannuronate oligosaccharide (MOS) is α-D-mannuronic acid polymer with 1,4-glycosidic linkages that possesses beneficial biological properties. The aim of this study was to investigate the hypouricemic effect of MOS in hyperuricemic mice and demonstrate the possible protective mechanisms involved. In this research, 200 mg/kg/day of MOS was orally administered to hyperuricemic mice for four weeks. The results showed that the MOS treatment significantly reduced the serum uric acid (SUA) level from 176.4 ± 7.9 μmol/L to 135.7 ± 10.9 μmol/L (p < 0.05). MOS alleviated the inflammatory response in the kidney. Moreover, MOS promoted uric acid excretion by regulating the protein levels of renal GLUT9, URAT1 and intestinal GLUT9, ABCG2. MOS modulated the gut microbiota in hyperuricemic mice and decreased the levels of Tyzzerella. In addition, research using antibiotic-induced pseudo-sterile mice demonstrated that the gut microbiota played a crucial role in reducing elevated serum uric acid of MOS in mice. In conclusion, MOS may be a potential candidate for alleviating HUA symptoms and regulating gut microbiota.

Mannan-oligosaccharides promote gut microecological recovery after antibiotic disturbance

“…MOS is an alpha- d -mannuronic acid polymer with 1,4-glycosidic linkages that possesses beneficial biological properties and has been proved effective against hyperuricemia, 41 while reducing hyperlipidemia and inflammation. 42 Moreover, it can activate and proliferate beneficial bacteria in large quantities, inhibit the growth of harmful bacteria, and regulate the microecological balance.…”

Anti-Hyperuricemic Effects of Extracts from Chaenomeles speciosa (Sweet) Nakai Fruits on Hyperuricemic Rats

“…HUA is a persistent metabolic condition characterized by an irregularity in the metabolism of purine, resulting in elevated levels of uric acid within the bloodstream [1]. The presence of HUA is widely recognized as a major contributing factor to the emergence of gout, hypertension, and diabetes [2].…”