Ameliorative role of conjugated linolenic acid isomers against oxidative DNA damage induced by sodium arsenite in rat model

Saha, Samrat; Ghosh, Mahua

doi:10.1016/j.fct.2010.09.011

Cited by 29 publications

(16 citation statements)

References 37 publications

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“…Previous studies have revealed that bitter gourd and snake gourd oil possesses various beneficial physiological activities such as antioxidant, anti-carcinogenic and hypocholesterolemic etc (Saha & Ghosh, 2011). CLnA isomers has showed potent beneficial role in reducing DNA damage and maintenance of erythrocyte integrity and fluidity due to higher antioxidant activity (Saha & Ghosh, 2010). In vitro assay such as DPPH assay shows higher antioxidant activity at higher concentration in case of bitter gourd seed oil as well as snake gourd seed oil, but in case of other methods conjugated linolenic acid (CLnA) showed higher antioxidant activity at lower concentration.…”

Section: Discussionmentioning

confidence: 99%

“…We have observed that different isomers of CLnA are able to combat the induced oxidative stress and genotoxicity, generated by ingestion of sodium arsenite, at different doses by reducing lipid peroxidation and improving antioxidant enzymes level (Saha & Ghosh, 2009, 2010, 2011. It has been reported that CLnA isomers are potent suppressor of growth of various human tumour cells (Igarashi & Miyazawa, 2000).…”

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

In vitro antioxidant study of vegetable oils containing conjugated linolenic acid isomers

Saha

Patra

Ghosh

2012

LWT - Food Science and Technology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

In vitro antioxidant study of vegetable oils containing conjugated linolenic acid isomers

Saha

Patra

Ghosh

2012

LWT - Food Science and Technology

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“…It has been reported that several seaweeds contain also conjugated trienoic and tetraenoic fatty acids . Recent studies demonstrated that CLnAs have cytotoxic effect on cultured human tumor cells , inhibits carcinogenesis , alters lipid metabolism in animals and humans , have antioxidant and anti‐inflammatory effects . It has been found that CLnA isomers are metabolized into CLA in vivo and in vitro , which may suggest that the health benefits may be due to the CLA.…”

Section: Introductionmentioning

confidence: 99%

Margarine supplemented with conjugated linolenic acid (CLnA) has no effect on atherosclerosis but alleviates the liver steatosis and affects the expression of lipid metabolism genes in apoE/LDLR^‐/‐ mice

Franczyk-Żarów¹,

Czyzyńska²,

Drahun³

et al. 2014

Euro J Lipid Sci & Tech

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Margarine supplemented with conjugated linolenic acid (CLnA) has no effect on atherosclerosis but alleviates the liver steatosis and affects the expression of lipid metabolism genes in apoE/LDLR -/-mice The objective of this study was to evaluate the effect of margarine supplemented with punicic acid (cis-9, trans-11,cis-13 C18:3) (CLnA) compared to CLA and linolenic acid (LnA) in apoE/LDLR -/-mice in two independent experiments: LONG (18 weeks) and SHORT (10 weeks). Liver weight was increased in CLA group in both studies. Hepatic steatosis was found in animals fed CLA and margarine diets but less signs of the steatosis were observed in mice fed LnA and CLnA diets. In LONG, TC was significantly increased in animals fed LnA, whereas LDL þ VLDL, HDL and TAG levels were unchanged. In mice fed CLnA the upregulated expression of PPARa and ACO was reported, however, SREBP-1 was 7-fold increased. Punicic acid and CLA isomers were determined both in adipose tissue and liver in CLnA fed mice. No effects of treatments on the area of atherosclerotic plaque were recognized. In conclusion margarine supplemented with CLA significantly increased liver weight and induced steatosis in mice in both studies. Our results did not support the notion that CLnA supplementation to the margarine possesses anti-atheroclerotic effect but it alleviated the liver steatosis and affected the expression of lipid metabolism genes.Practical applications: It has been reported that conjugated linolenic acid isomers (CLnA) have several health-related effects. Margarine with omega-3 fatty acids is commonly used as a functional food product. Therefore, the effect of margarine supplemented with CLnA compared to CLA and linolenic acid (LnA) in apoE/LDLR -/-mice was evaluated. CLA supplementation increased liver weight and lead to steatosis, but CLnA alleviated the liver steatosis in mice. No effects of treatments on the area of atherosclerotic plaque were recognized. The up-regulated expression of PPARa and SREBP-1 and their target genes ACO and FAS was reported for studied fatty acids. More research is warranted to assess the potential health-related properties of conjugated linolenic acids as bioactive compounds in the context of production of functional foods.

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“…Regarding the CLA compounds, Saha et al reported that PA possessed hydroxyl radical scavenging activity, reducing properties and metal chelation particularly demonstrated by the trans isomer. Also, they reported that PA was a potent antioxidant agent, caused reduction in lipid peroxidation and scavenged free radicals in arsenic-induced toxicity [26] .…”

Section: Antioxidant and Antiinflammatory Effects Of Pamentioning

confidence: 99%

Hatice Asli Bedel, Nur Tukel Turgut, Aysegul Ugur Kurtoglu, Coskun Usta

Bedel¹,

Turgut²,

Kurtoğlu³

et al. 2017

pharmaceutical-sciences

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Bedel, et al.: Pharmacology of Punicic AcidPlant extracts and nutraceuticals are the most ancient and widespread form of medication employed by the general population. The pomegranate is a prehistoric, mystical and a highly differentiated fruit. Moreover, pomegranate is found in some medicinal systems as a cure for a variety of illnesses. Pomegranate has been used for a long time for nutraceutical purposes. Current research indicates that the most medicinally useful pomegranate components include ellagitannins, anthocyanins, anthocyanidins, flavonoids, estrogenic flavonols and flavones. Also pomegranate seed oil contains 64-83% punicic acid. Therefore, this review focussed on the effects of punicic acid, particularly those that have been reported such as the anticarcinogenic, antioxidant, antiinflammatory and antidiabetic effects. As nutraceuticals appear to play a major role in the prophylaxis of various diseases, punicic acid could be an important and phytoconstituent among these agents. Nutraceuticals are generally regarded as safe to use with lower incidence of side effects. In spite of all these reports it is obvious that there is a clear need for more clinical studies.

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Ameliorative role of conjugated linolenic acid isomers against oxidative DNA damage induced by sodium arsenite in rat model

Cited by 29 publications

References 37 publications

In vitro antioxidant study of vegetable oils containing conjugated linolenic acid isomers

In vitro antioxidant study of vegetable oils containing conjugated linolenic acid isomers

Margarine supplemented with conjugated linolenic acid (CLnA) has no effect on atherosclerosis but alleviates the liver steatosis and affects the expression of lipid metabolism genes in apoE/LDLR^‐/‐ mice

Hatice Asli Bedel, Nur Tukel Turgut, Aysegul Ugur Kurtoglu, Coskun Usta

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Ameliorative role of conjugated linolenic acid isomers against oxidative DNA damage induced by sodium arsenite in rat model

Cited by 29 publications

References 37 publications

In vitro antioxidant study of vegetable oils containing conjugated linolenic acid isomers

In vitro antioxidant study of vegetable oils containing conjugated linolenic acid isomers

Margarine supplemented with conjugated linolenic acid (CLnA) has no effect on atherosclerosis but alleviates the liver steatosis and affects the expression of lipid metabolism genes in apoE/LDLR‐/‐ mice

Hatice Asli Bedel, Nur Tukel Turgut, Aysegul Ugur Kurtoglu, Coskun Usta

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Margarine supplemented with conjugated linolenic acid (CLnA) has no effect on atherosclerosis but alleviates the liver steatosis and affects the expression of lipid metabolism genes in apoE/LDLR^‐/‐ mice