Ameloblastoma of the anterior mandible

Hariram,; Mohammad, Shadab; Malkunje, Laxman R; Singh, Nidhi; Das, Sugata; Mehta, Gagan

doi:10.4103/0975-5950.140173

Cited by 18 publications

(19 citation statements)

References 13 publications

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“…It is usually asymptomatic and discovered incidentally on routine radiographs, but it can present with jaw expansion which may lead to root resorption and tooth displacement. 3 It appears on x-ray as a lytic lesion with scalloped margins. 4 Treatment can be either conservative or radical depending on the clinical type, however, surgery is considered the elective treatment of ameloblastoma.…”

Section: Discussionmentioning

confidence: 99%

Difficult airway management: burning no bridges

Aloqab

Chandrashekaraiah

Shah

et al. 2019

Sri Lankan J Anaesthesiol

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Ameloblastoma is a benign tumor that arises from odontogenic epithelium. It may present a challenge to anaesthetists as it can distort the facial contours and can make bag-mask ventilation difficult. We present a first case of ameloblastoma in our hospital where a 38year-old female was scheduled for a right mandibulectomy and reconstruction of the mandible with a custom-made titanium implant. Awake fiberoptic intubation was planned as a first choice for induction of anaesthesia as any other technique may have led to serious airway complications. We believe that airway management in difficult airway cases should always be based on the principle of "burning no bridges".

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Section: Discussionmentioning

confidence: 99%

Difficult airway management: burning no bridges

Aloqab

Chandrashekaraiah

Shah

et al. 2019

Sri Lankan J Anaesthesiol

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“…Ameloblastomas may arise from remnants of dental lamina or Hertwig's sheath and epithelium of odontogenic cyst (Diniz, Gomes, Sousa, Xavier, & Gomez, ; Hariram, Malkunje, Singh, Das, & Mehta, ). Tumor growth is determined by the balance between proliferative activity and cell death.…”

Section: Introductionmentioning

confidence: 99%

Bcl‐2 is a prognostic marker and its silencing inhibits recurrence in ameloblastomas

Kim¹,

Kim²,

Bazarsad³

et al. 2019

Oral Diseases

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Objectives Ameloblastomas are the most common odontogenic epithelial tumors with high recurrence rate. The aim of this study was to identify apoptosis‐related genes with recurrence of ameloblastomas and to evaluate its feasibility as a prognostic marker and as a target molecule preventing from recurrence. Materials and Methods Public microarray data were analyzed. To evaluate their expression in ameloblastoma patients, immunohistochemical staining was performed in 89 human ameloblastoma tissues. Quantitative PCR was performed by use of ameloblastoma cell line (AM‐1). Fluorescence activated cell sorting analysis and western blotting were conducted following transfection with siRNA. Further, AM‐1 cells were implanted in the renal subcapsular layer of immunodeficient mice. Results Microarray data analysis revealed that osteoprotegerin (OPG) and B‐cell lymphoma 2 (Bcl‐2) were the two most upregulated genes in ameloblastoma. Only Bcl‐2 expression was significantly (p = 0.020) associated with recurrence in conservative treatment group (n = 17) among 89 patients. Silencing of Bcl‐2 increased apoptosis in AM‐1 cells in vitro and inhibited tumor nodule formation of AM‐1 cells in vivo. Conclusion These results suggest that Bcl‐2 expression is a useful biomarker to predict recurrence of ameloblastomas, and as a therapeutic target molecule to prevent recurrence of ameloblastoma.

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“…[ 2 ] Men are involved more than female[ 3 ] and more than 80% of ameloblastomas are in the mandible (mostly angle and ramus). [ 4 ] Clinically, jaw swelling and pain are the most frequent presenting symptoms. [ 5 ] Radiographically, ameloblastoma is included solid (multicystic) and unicystic.…”

Section: Introductionmentioning

confidence: 99%

“…[ 5 ] Radiographically, ameloblastoma is included solid (multicystic) and unicystic. [ 4 6 7 ] Microscopically, the follicular and plexiform patterns are the most frequent and less common histopathology subtypes include the acanthomatous, granular cell, desmoplastic, and basal cell. [ 5 ] Granular cell ameloblastoma (GCA) is a rare subtype (<3/5%).…”

Section: Introductionmentioning

confidence: 99%

Granular cell type of ameloblastoma

et al. 2018

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Ameloblastoma is a locally invasive tumor derived from odontogenic epithelium. An uncommon variant of ameloblastoma is granular cell type, which cannot distinguish from other ameloblastoma subtypes by clinical and radiographic findings alone. Only review of it's microscopic features allows distinction from other subtypes. The purpose of this article is to present a case of granular cell ameloblastoma. This subtype should be distinguished from the other histopathologic subtypes because of it's higher recurrence rate and more aggressive biological behavior. Radiographic and histologic findings as well as treatment are also discussed.

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Ameloblastoma of the anterior mandible

Cited by 18 publications

References 13 publications

Difficult airway management: burning no bridges

Difficult airway management: burning no bridges

Bcl‐2 is a prognostic marker and its silencing inhibits recurrence in ameloblastomas

Granular cell type of ameloblastoma

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