Amentoflavone-induced oxidative stress activates NF-E2-related factor 2 via the p38 MAP kinase-AKT pathway in human keratinocytes

Wahyudi, Lilik Duwi; Jeong, Jong Ok; Yang, Heejung; Kim, Junghwan

doi:10.1016/j.biocel.2018.04.006

Cited by 28 publications

(16 citation statements)

References 31 publications

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“…However, Wahyudi et al (2018) reveal that AMF exhibits the prooxidative activity through the Nrf2 activation induced by ROS-mediated the activation of p38-AKT pathway in HaCaT cells. In addition, AMF plays key role in the oxidant/antioxidant balance by suppressing the production of inflammatory mediators (i.e., NO, COX-2) and pro-inflammatory cytokines (i.e., TNF-α, IL-1β and IL-6), and the activation of NF-κB signaling pathways in vitro or/and in vivo ( Ishola et al, 2013 ; Sakthivel and Guruvayoorappan, 2013 ).…”

Section: The Multifunctional Biological Activities Of Amentoflavonementioning

confidence: 92%

Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid

Xiong

Tang²,

Lai³

et al. 2021

Front. Pharmacol.

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Amentoflavone is an active phenolic compound isolated from Selaginella tamariscina over 40 years. Amentoflavone has been extensively recorded as a molecule which displays multifunctional biological activities. Especially, amentoflavone involves in anti-cancer activity by mediating various signaling pathways such as extracellular signal-regulated kinase (ERK), nuclear factor kappa-B (NF-κB) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), and emerges anti-SARS-CoV-2 effect via binding towards the main protease (Mpro/3CLpro), spike protein receptor binding domain (RBD) and RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. Therefore, amentoflavone is considered to be a promising therapeutic agent for clinical research. Considering the multifunction of amentoflavone, the current review comprehensively discuss the chemistry, the progress in its diverse biological activities, including anti-inflammatory, anti-oxidation, anti-microorganism, metabolism regulation, neuroprotection, radioprotection, musculoskeletal protection and antidepressant, specially the fascinating role against various types of cancers. In addition, the bioavailability and drug delivery of amentoflavone, the molecular mechanisms underlying the activities of amentoflavone, the molecular docking simulation of amentoflavone through in silico approach and anti-SARS-CoV-2 effect of amentoflavone are discussed.

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Section: The Multifunctional Biological Activities Of Amentoflavonementioning

confidence: 92%

Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid

Xiong

Tang²,

Lai³

et al. 2021

Front. Pharmacol.

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show abstract

“…A key transcription factor that responds to oxidative stress is nuclear factor erythroid 2-related factor 2 (Nrf2) and its activation is related with prevention of aging, inflammation and cancer [ 96 ]. A recent study [ 97 ] found that amentoflavone (6) could trigger Nrf2 activation through ROS-mediated activation of the p38-AKT/PKB pathway in HaCaT keratinocytes.…”

Section: Bioactive Secondary Metabolites From Juniperus mentioning

confidence: 99%

The Current Status of the Pharmaceutical Potential of Juniperus L. Metabolites

Tavares

Seca

2018

Medicines

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Background: Plants and their derived natural compounds possess various biological and therapeutic properties, which turns them into an increasing topic of interest and research. Juniperus genus is diverse in species, with several traditional medicines reported, and rich in natural compounds with potential for development of new drugs. Methods: The research for this review were based in the Scopus and Web of Science databases using terms combining Juniperus, secondary metabolites names, and biological activities. This is not an exhaustive review of Juniperus compounds with biological activities, but rather a critical selection taking into account the following criteria: (i) studies involving the most recent methodologies for quantitative evaluation of biological activities; and (ii) the compounds with the highest number of studies published in the last four years. Results: From Juniperus species, several diterpenes, flavonoids, and one lignan were emphasized taking into account their level of activity against several targets. Antitumor activity is by far the most studied, being followed by antibacterial and antiviral activities. Deoxypodophyllotoxin and one dehydroabietic acid derivative appears to be the most promising lead compounds. Conclusions: This review demonstrates the Juniperus species value as a source of secondary metabolites with relevant pharmaceutical potential.

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“…As result, medicarpin significantly increased the NRF2-luciferase activity at 50 μM ( Figure 4 ). While many existing natural products, such as amentoflavone [ 33 ] and juglone [ 22 ], contribute to the stabilization of NRF2, medicarpin may function differently by increasing the transcriptional level of NRF2 , thereby regulating the expression of NRF2 target genes.…”

Section: Resultsmentioning

confidence: 99%

Medicarpin Increases Antioxidant Genes by Inducing NRF2 Transcriptional Level in HeLa Cells

et al. 2022

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The nuclear factor erythroid-derived 2-related factor 2 (NRF2) plays a pivotal role in the regulation of genes involved in oxidative stress and drug detoxification. Therefore, it is important to find NRF2 inducers to protect cells from excessive oxidative damage. Here, we investigated the effect of medicarpin isolated from the root of Robinia pseudoacacia L. on the activity of NRF2 in HeLa cells. Medicarpin significantly induced the antioxidant response elements (ARE)-luciferase activity in a concentration-dependent manner. Furthermore, medicarpin not only induced HO-1, GCLC, and NQO1 mRNA by translocating NRF2 to the nucleus but also induced the mRNA level of NRF2. To verify the NRF2 induction mechanism by medicarpin, ~2 kb of NRF2 promoter-luciferase assay was executed. As a result, medicarpin significantly induced NRF2-luciferase activity. Moreover, medicarpin strongly inhibited the ubiquitin-dependent proteasomal degradation of NRF2. Thus, medicarpin might protect cells by promoting the NRF2 transcriptional activity.

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Amentoflavone-induced oxidative stress activates NF-E2-related factor 2 via the p38 MAP kinase-AKT pathway in human keratinocytes

Cited by 28 publications

References 31 publications

Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid

Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid

The Current Status of the Pharmaceutical Potential of Juniperus L. Metabolites

Medicarpin Increases Antioxidant Genes by Inducing NRF2 Transcriptional Level in HeLa Cells

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