Amido-modified polylactide for potential tissue engineering applications

Abayasinghe, Nilmini K.; Perera, K. Prasanna U.; Thomas, Chuck B.; Daly, Annie; Suresh, Santhosh; Burg, Karen J. L.; Harrison, Graham M.; Smith, Dennis W.

doi:10.1163/156856204323046861

Cited by 25 publications

(14 citation statements)

References 18 publications

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“…Typically, polylactide and polyglycolide are the most widely used polymers due to their mild inflammatory response, complete biodegradability, and Food and Drug Administrative approval for a variety of applications. However, polymeric biomaterials typically do not promote high levels of cellular attachment without either surface modification or the incorporation of a secondary material such as β-TCP, when compared with extracellular matrix based materials [109]. In vitro tissue engineering has shown poly-L-lactide-co-glycolide to be capable of allowing mineralization and osteogenic differentiation, as detected through histological and molecular characterization [85,110,111].…”

Section: Biomaterialsmentioning

confidence: 99%

Regenerative Engineering in Maxillofacial Reconstruction

Shaul

Davis

Burg

2016

Regen. Eng. Transl. Med.

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Oral cancer is the sixth most common cancer worldwide, with approximately 275,000 new cases each year. In some countries, mortality rates reach as high as 70 %. For patients that survive, bodily functions of speaking, swallowing, and chewing are severely compromised. Although there has been improvement in free tissue transfer techniques and virtual planning with implant placement, maxillofacial reconstruction techniques need refinement to allow greater improvement in functional outcomes and quality of life. Regenerative engineering principles provide a potential means of improving maxillofacial tissue regeneration. Maxillofacial reconstruction requires unique insights to maximize clinical impact. Because traditional cancer treatment can include radiation therapy, defect sites may experience hypoxia and experience thrombosis and fibrosis, which complicate restoration [1]. Several cell sources, such as periosteal-derived progenitor cells (PDPCs) and bone marrow-derived mesenchymal stem cells (BMSCs) have been evaluated for use in maxillofacial reconstruction, with variable success. From our comprehensive review of the literature, there is a significant need to further the application of regenerative engineering principles to maxillofacial regeneration following oral cancer treatment. Lay Summary The prevalence of oral cancer and limitations of treatments invites regenerative engineering approaches. While combatting cancer, tissue removal, radiation, and/or chemotherapy often significantly reduce the patient's quality of life. A high-quality Bfunctional outcome^following treatment means the ability to readily perform the seemingly simplest of biological tasks that humans often take for granted-swallowing, breathing, coughing, and speaking intelligibly. Indeed, damage due to clinical treatments may include normal tissues at the cancer site but can also extend to surrounding tissues such as teeth. A regenerative engineering approach, involving tissue enhancement with cellular materials, would allow tissue to be rebuilt following and during potentially harmful clinical treatments.

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Section: Biomaterialsmentioning

confidence: 99%

Regenerative Engineering in Maxillofacial Reconstruction

Shaul

Davis

Burg

2016

Regen. Eng. Transl. Med.

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“…Versatile polydepsipeptides, with or without pendant functional groups, can be synthesized via ROP of various morpholine‐2,5‐dione derivatives. Polydepsipeptides are potential candidates for a wide range of biomedical applications 27, 41–43…”

Section: Synthesis Of Biodegradable Polymer Derived From Amino Acidsmentioning

confidence: 99%

“…These polymers exhibited in vitro and in vivo biocompatibility and had projected degradation half‐lives of up to 20 months in vivo. Abayasinghe et al prepared PEA copolymers based on L‐lactide and a new depsipeptide were prepared by ROP in the presence of Sn(Oct) 2 as the catalyst 42. Preliminary results indicate that these novel materials exhibit reduced cell attachment compared to PLA and may have potential use in biomedical applications.…”

Section: Pharmaceutical and Biomedical Applicationmentioning

confidence: 99%

Biodegradable Polymers Derived From Amino Acids

Khan

Saravanan

Farah

et al. 2011

Macromolecular Bioscience

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In the past three decades, the use of polymeric materials has increased dramatically for biomedical applications. Many α-amino acids derived biodegradable polymers have also been intensely developed with the main goal to obtain bio-mimicking functional biomaterials. Polymers derived from α-amino acids may offer many advantages, as these polymers: (a) can be modified further to introduce new functions such as imaging, molecular targeting and drugs can be conjugated chemically to these polymers, (b) can improve on better biological properties like cell migration, adhesion and biodegradability, (c) can improve on mechanical and thermal properties and (d) their degradation products are expected to be non-toxic and readily metabolized/excreted from the body. This manuscript focuses on biodegradable polymers derived from natural amino acids, their synthesis, biocompatibility and biomedical applications. It is observed that polymers derived from α-amino acids constitute a promising family of biodegradable materials. These provide innovative multifunctional polymers possessing amino acid side groups with biological activity and with innumerous potential applications.

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“…In 1985, Helder et al synthesized polydepsipeptides by ROP of morpholine-2,5-dione derivatives for the first time [36]. Since then, morpholine-2,5-dione derivatives, which have an ester group and an amide group in one six-membered ring, have been used to synthesize various biodegradable copolymers [37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Poly(lactide-co-glycolide-co-3(S)-methyl-morpholine-2,5-dione) Nanofibrous Scaffolds for Tissue Engineering

et al. 2016

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Biomimetic scaffolds have been investigated in vascular tissue engineering for many years. Excellent biodegradable materials are desired as temporary scaffolds to support cell growth and disappear gradually with the progress of guided tissue regeneration. In the present paper, a series of biodegradable copolymers were synthesized and used to prepared micro/nanofibrous scaffolds for vascular tissue engineering. Poly(lactide-co-glycolide-co-3(S)-methyl-morpholine-2,5-dione) [P(LA-co-GA-co-MMD)] copolymers with different L-lactide (LA), glycolide (GA), and 3(S)-methyl-2,5-morpholinedione (MMD) contents were synthesized using stannous octoate as a catalyst. Moreover, the P(LA-co-GA-co-MMD) nanofibrous scaffolds were prepared by electrospinning technology. The morphology of scaffolds was analyzed by scanning electron microscopy (SEM), and the results showed that the fibers are smooth, regular, and randomly oriented with diameters of 700˘100 nm. The weight loss of scaffolds increased significantly with the increasing content of MMD, indicating good biodegradable property of the scaffolds. In addition, the cytocompatibility of electrospun nanofibrous scaffolds was tested by human umbilical vein endothelial cells. It is demonstrated that the cells could attach and proliferate well on P(LA-co-GA-co-MMD) scaffolds and, consequently, form a cell monolayer fully covering on the scaffold surface. Furthermore, the P(LA-co-GA-co-MMD) scaffolds benefit to excellent cell infiltration after subcutaneous implantation. These results indicated that the P(LA-co-GA-co-MMD) nanofibrous scaffolds could be potential candidates for vascular tissue engineering.

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Amido-modified polylactide for potential tissue engineering applications

Cited by 25 publications

References 18 publications

Regenerative Engineering in Maxillofacial Reconstruction

Regenerative Engineering in Maxillofacial Reconstruction

Biodegradable Polymers Derived From Amino Acids

Electrospun Poly(lactide-co-glycolide-co-3(S)-methyl-morpholine-2,5-dione) Nanofibrous Scaffolds for Tissue Engineering

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