Amino-functionalized mesoporous bioactive glass for drug delivery

Abstract

An amino-functionalized mesoporous bioactive glass (N-MBG) with a high drug loading capacity and longer drug release time was successfully prepared by using 3-aminopropyltriethoxysilane (APTES) in a short-time chemical reaction. The drug release performance of an MBG and the N-MBG were studied by loading gentamicin sulfate (GS) in a simulated body fluid solution. The results showed that the surface area of the N-MBG increases to 355.01 mg after amination at 80 °C for 1 h compared with that of the MBG (288.07 mg). Meanwhile, the surface zeta-potential of the N-MBG charges from the original negative charge (-10.06 mV) to the positive charge (+5.30 mV). Furthermore, the GS loading rate of the N-MBG is up to 62.92 ± 2.02%, higher than that of the MBG (48.90 ± 1.71%). In addition, the N-MBG has a longer drug release period and the seven-day accumulative release from the N-MBG reached only 45.9 ± 1.8%, significantly lower than that of the MBG, 60.7 ± 2.3%. In vitro bioactivity tests suggested that the N-MBG exhibited good biological activity. In conclusion, the N-MBG with a higher loading capacity and longer drug release time can serve as a promising candidate as a drug carrier.

Mesoporous bioactive glass nanoparticles doped with magnesium: drug delivery and acellular in vitro bioactivity

“…7, 8 and 9(b)), it was observed that for the BG composition, the nanoparticle formation appeared to be impeded with the newly formed layer of small Ca-P crystallites, which conrms their bioactivity, as was also reported by other research groups. 11,45,46 In the case of BG-Mg 3 and BG-Mg 5 , the SEM images did not present the globular shape frequently found for apatite, but only showed that the particles had agglomerated, indicating the formation of an accentuated pseudo-crystalline calcium phosphate layer on their surfaces and between the particles. These results are consistent with the FTIR and XRD observations.…”

3D bioactive composite scaffolds for bone tissue engineering

“…10 SEM images of the amine-coated MBG before (A) and after (B) soaking in SBF. Formation of a crystalline HA layer was confirmed on Fourier transform infrared spectroscopy [172] . …”

“…In vitro bioactivity was also improved, with increased formation of surface hydroxyapatite found after soaking in simulated body fluid for 3 days ( Fig. 10 ) [172] . MBGs have been utilised by several other studies to create composite scaffolds with increased bioactivity [170] , [173] , [174] , [175] .…”

3D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineering

“…Furthermore, nanosilicates can be homogenously distributed within a polymeric matrix due to their charged surfaces [38–41]. This capability provides an advantage over alternative bioactive nanomaterials, like hydroxyapatite or mesoporous bioactive glasses, which require chemical modifications to the surface to endow the particles with improved electrostatic characteristics [42, 43].…”