Aminoglycosides and Sugar Components in Other Secondary Metabolites

Piepersberg, Wolfgang; Distler, Jürgen

doi:10.1002/9783527620999.ch10g

Cited by 6 publications

(8 citation statements)

References 227 publications

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“…Hence the production of lower quantities pigment can be reasoned for the repression of biosynthetic enzymes by high concentration glucose in the media. Similar observations were made in the production of many amino‐glycoside antibiotics produced by actinomycetes via repression of biosynthetic enzymes . The glucose activates adenylate cyclase to convert ATP to cAMP by G‐protein signaling pathway.…”

Section: Resultssupporting

confidence: 66%

“…The mechanisms involved in glucose repression have been extensively investigated in Saccharomyces cerevisiae . Glucose also influences the formation of many aminoglycoside antibiotics produced by actinomycetes via repression of biosynthetic enzymes . In bacteria, catabolite repression is known to be subject to the growth rate on glucose and cells are relieved from repression at a low concentration .…”

Section: Introductionmentioning

confidence: 99%

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Glucose released by hydrolytic activity of amylase influences the pigment synthesis in Penicillium sp NIOM‐02

Puttananjaiah

Dhale

2012

J. Basic Microbiol.

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Carbon catabolite repression is generally considered as a regulatory mechanism to ensure sequential synthesis of secondary metabolites. In this study we made an attempt to understand the influence of amylase activity on pigment synthesis in Penicillium sp NIOM-02. The amylase activity is inversely proportional to pigment production. The high performance liquid chromatography analysis of amylase reaction revealed glucose as the major product of starch hydrolysis. The fungus grown in acarbose (inhibitor of amylase) incorporated media produced higher quantities of pigments. Apparently, glucose released due to amylase activity influenced the pigment synthesis by cAMP signaling pathway.

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Section: Resultssupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Glucose released by hydrolytic activity of amylase influences the pigment synthesis in Penicillium sp NIOM‐02

Puttananjaiah

Dhale

2012

J. Basic Microbiol.

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“…After exhausting the preferred carbon source, bacteria turn to the ''secondbest'' carbon source, and this often correlates temporally with the onset of antibiotic production, which is associated with growth cessation [36]. Glucose is a preferred carbon source for many actinomycetes and effects global repression of antibiotic production [37,118], which is why in industrial fermentations, polysaccharides (e.g., starch), oligosaccharides (e.g., lactose) and oils (e.g., soybean oil, methyloleate) are commonly used.…”

Section: Genetic Control In Response To Carbon Nitrogen and Phosphorousmentioning

confidence: 99%

Triggers and cues that activate antibiotic production by actinomycetes

Zhu

Sandiford

Wezel

2014

Journal of Industrial Microbiology and Biotechnology

165

141

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Actinomycetes are a rich source of natural products, and these mycelial bacteria produce the majority of the known antibiotics. The increasing difficulty to find new drugs via high-throughput screening has led to a decline in antibiotic research, while infectious diseases associated with multidrug resistance are spreading rapidly. Here we review new approaches and ideas that are currently being developed to increase our chances of finding novel antimicrobials, with focus on genetic, chemical, and ecological methods to elicit the expression of biosynthetic gene clusters. The genome sequencing revolution identified numerous gene clusters for natural products in actinomycetes, associated with a potentially huge reservoir of unknown molecules, and prioritizing them is a major challenge for in silico screening-based approaches. Some antibiotics are likely only expressed under very specific conditions, such as interaction with other microbes, which explains the renewed interest in soil and marine ecology. The identification of new gene clusters, as well as chemical elicitors and culturing conditions that activate their expression, should allow scientists to reinforce their efforts to find the necessary novel antimicrobial drugs.

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“…This is remarkable, because presently only a small number of examples are known where secondary metabolites are suppressed in the presence of specific carbon sources, while CCR is a well-known concept to control primary metabolism (summarized in Ruiz et al, 2010 ). For instance, glucose depresses formation of aminoglycoside antibiotic via repression of the biosynthetic enzymes ( Demain, 1989 ; Piepersberg and Distler, 1997 ). Also, production of β-lactam antibiotics and macrocyclic polyketides are regulated by the carbon source.…”

Section: Discussionmentioning

confidence: 99%

Carbon Catabolite Repression Regulates the Production of the Unique Volatile Sodorifen of Serratia plymuthica 4Rx13

2017

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Microorganisms are capable of synthesizing a plethora of secondary metabolites including the long-overlooked volatile organic compounds. Little knowledge has been accumulated regarding the regulation of the biosynthesis of such mVOCs. The emission of the unique compound sodorifen of Serratia plymuthica isolates was significantly reduced in minimal medium with glucose, while succinate elevated sodorifen release. The hypothesis of carbon catabolite repression (CCR) acting as a major control entity on the synthesis of mVOCs was proven by genetic evidence. Central components of the typical CCR of Gram-negative bacteria such as the adenylate cyclase (CYA), the cAMP binding receptor protein (CRP), and the catabolite responsive element (CRE) were removed by insertional mutagenesis. CYA, CRP, CRE1 mutants revealed a lower sodorifen release. Moreover, the emission potential of other S. plymuthica isolates was also evaluated.

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Aminoglycosides and Sugar Components in Other Secondary Metabolites

Cited by 6 publications

References 227 publications

Glucose released by hydrolytic activity of amylase influences the pigment synthesis in Penicillium sp NIOM‐02

Glucose released by hydrolytic activity of amylase influences the pigment synthesis in Penicillium sp NIOM‐02

Triggers and cues that activate antibiotic production by actinomycetes

Carbon Catabolite Repression Regulates the Production of the Unique Volatile Sodorifen of Serratia plymuthica 4Rx13

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