Aminolevulinic acid with gold nanoparticles: a novel theranostic agent for atherosclerosis

Gonçalves, Karina de Oliveira; Silva, Mônica Nascimento da; Sicchieri, Letícia Bonfante; Silva, Flávia Rodrigues de Oliveira; Matos, Ricardo Almeida de; Courrol, Lilia Coronato

doi:10.1039/c4an02166e

Cited by 31 publications

(15 citation statements)

References 17 publications

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“…The injected ALA/AuNPs accumulated into atheromatous plaques in a rabbit model of atherosclerosis and their ALA was converted to PPIX. The isolated blood and feces of rabbit demonstrated an increase in the fluorescence intensity of porphyrin, indicating stable encapsulation of ALA into gold nanoparticles and further conversion to fluorescent PPIX upon photo-exposure 36 .…”

Section: Atherosclerosis and Nanoparticle Approachesmentioning

confidence: 98%

“…ALA-derived PPIX has been shown to accumulate especially in atherosclerotic plaques, and its fluorescence intensity can be positively correlated with the plaque macrophage content 34 , 35 . To harness the photodynamic properties of ALA-derived PPIX for early diagnosis and therapy of atherosclerosis, Gonçalves et al, formulated PEGylated ALA gold nanoparticles (ALA:AuNPs) with an average size of 18 nm and pH (~5-8.0)-dependent zeta potential (10-40 mV) 36 . The injected ALA/AuNPs accumulated into atheromatous plaques in a rabbit model of atherosclerosis and their ALA was converted to PPIX.…”

Section: Atherosclerosis and Nanoparticle Approachesmentioning

confidence: 99%

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Recent strategies to design vascular theranostic nanoparticles

Gupta¹,

Lee²,

Boire³

et al. 2017

Nanotheranostics

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Vascular disease is a leading cause of death and disability worldwide. Current surgical intervention and treatment options for vascular diseases have exhibited limited long-term success, emphasizing the need to develop advanced treatment paradigms for early detection and more effective treatment of dysfunctional cells in a specific blood vessel lesion. Advances in targeted nanoparticles mediating cargo delivery enables more robust prevention, screening, diagnosis, and treatment of vascular disorders. In particular, nanotheranostics integrates diagnostic imaging and therapeutic function into a single agent, and is an emerging platform towards more effective and localized vascular treatment. This review article highlights recent advances and current challenges associated with the utilization of targeted nanoparticles for real-time diagnosis and treatment of vascular diseases. Given recent developments, nanotheranostics offers great potential to serve as an effective platform for targeted, localized, and personalized vascular treatment.

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Section: Atherosclerosis and Nanoparticle Approachesmentioning

confidence: 98%

Section: Atherosclerosis and Nanoparticle Approachesmentioning

confidence: 99%

Recent strategies to design vascular theranostic nanoparticles

Gupta¹,

Lee²,

Boire³

et al. 2017

Nanotheranostics

View full text Add to dashboard Cite

show abstract

“…This behavior causes many cardiovascular diseases [215]. For example, 5-aminolevulinic acid (ALA) AuNPs functionalized with PEG (ALA-AuNPs-PEG) were synthesized and administered to rabbits to evaluate their use in clinical practice as therapeutic agents for atherosclerosis [216]. ALA is used to differentiate between healthy and diseased tissue in the diagnosis of tumors.…”

Section: Treatment Of Other Diseasesmentioning

confidence: 99%

“…Peng et al [218] showed that PPIX was detected in atheromatous plaques after the intravenous administration of ALA in rabbits. Similarly, Oliveira et al [216] measured the fluorescence of porphyrin extracted from the blood and feces of rabbits after administration of ALA-AuNPs-PEG, detecting an increase in porphyrin emission and the high stability of ALA when attached to the AuNPs-PEG. These results suggested that this method can aid in the diagnosis and treatment of atherosclerosis with good sensitivity.…”

Section: Treatment Of Other Diseasesmentioning

confidence: 99%

Nanoengineering of Gold Nanoparticles: Green Synthesis, Characterization, and Applications

et al. 2019

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The fundamental aspects of the manufacturing of gold nanoparticles (AuNPs) are discussed in this review. In particular, attention is devoted to the development of a simple and versatile method for the preparation of these nanoparticles. Eco-friendly synthetic routes, such as wet chemistry and biosynthesis with the aid of polymers, are of particular interest. Polymers can act as reducing and/or capping agents, or as soft templates leading to hybrid nanomaterials. This methodology allows control of the synthesis and stability of nanomaterials with novel properties. Thus, this review focus on a fundamental study of AuNPs properties and different techniques to characterize them, e.g., Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), UV-Visible spectroscopy, Dynamic Light Scattering (DLS), X-Ray Diffraction (XRD), X-Ray Photoelectron Spectroscopy, Small-angle X-Ray Scattering (SAXS), and rheology. Recently, AuNPs obtained by “green” synthesis have been applied in catalysis, in medicine, and as antibacterials, sensors, among others.

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“…Cross‐linked dextran‐coated iron oxide nanoparticle provided 600‐fold efficacy in the destruction of plaque macrophages and substantially reduced skin phototoxicity as compared to conventional photosensitizers. Furthermore, ALA associated with gold nanoparticles has shown increased specificity to atherosclerotic plaques …”

Section: Selective Drug Deliverymentioning

confidence: 99%

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?

Jain

Zellweger

Wagnières

et al. 2017

Cardiovascular Therapeutics

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Summary Acute coronary syndrome is a life‐threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction of a coronary artery. During the last decade, scientific evidence demonstrated that when an acute coronary event occurs, several nonculprit plaques are in a “vulnerable” state. Among the promising approaches, several investigations provided evidence of photodynamic therapy (PDT)‐induced stabilization and regression of atherosclerotic plaque. Significant development of PDT strategies improved its therapeutic outcome. This review addresses PDT's pertinence and major problems/challenges toward its translation to a clinical reality.

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Aminolevulinic acid with gold nanoparticles: a novel theranostic agent for atherosclerosis

Cited by 31 publications

References 17 publications

Recent strategies to design vascular theranostic nanoparticles

Recent strategies to design vascular theranostic nanoparticles

Nanoengineering of Gold Nanoparticles: Green Synthesis, Characterization, and Applications

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?

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