α-(-)-bisabolol Reduces Pro-inflammatory Cytokine Production and Ameliorates Skin Inflammation

Abstract

α-(-)-bisabolol is a natural monocyclic sesquiterpene present in the essential oil has generated considerable interest in the chemical and pharmaceutical industries and currently in use in various formulations, mainly in cosmetics. This study was undertaken to evaluate its therapeutic profile against skin inflammation using in-vitro, in-vivo and in-silico assays. Lipopolysachharide (LPS) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced production of proinflammatory cytokines (TNF-α and IL-6) in macrophage cells as well as in TPA-induced skin inflammation in mice was significantly inhibited by α-(-)-bisabolol. TPA-induced ear thickness, ear weight and lipid peroxidation and histopathological damage in the ear tissue were also significantly inhibited by topical application of α-(-)-bisabolol in a dose dependent manner. In-vitro and in-vivo toxicity profiles indicate that it is safe for topical application on skin. Molecular docking study also revealed its strong binding affinity to the active site of the pro-inflammatory proteins. These findings suggested that α-(-)-bisabolol may be a useful therapeutic candidate for the treatment of skin inflammation.

Incorporation and Release Kinetics of Alpha-Bisabolol From PCL and Chitosan/Guar Gum Membranes

“…Also according to Madhavan (1999), alpha-bisabolol was negative in a dermal photosensitization study with guinea pigs and, in addition, a 28-day dermal toxicity study performed through the application of a solution containing 4% of alpha-bisabolol with 87.5% purity on rats showed that the no-observable-adverse-effect level (NOAEL) was equal to 200 mg/kg/day. More recent data show that alpha-bisabolol is not irritant to rabbits when topically administered at 1% over an area of one square inch (Maurya et al, 2014). Based on the evidence described above, and on the values of the ratio between the mass of the membranes per area (around 6 and 5 mg/cm 2 for PCL and Ch-G membranes, respectively), it is possible to assume that even the cumulative dose of 300 mgalphabisabolol/gmembrane administered through the skin would be safe to treat skin lesions.…”

GC-MS and NMR analysis of the bioactive compounds from the crude extracts of Waltheria indica and the histopathological changes induced in albino rats challenged with Naja nigricollis venom

“…It has been widely used as an ingredient in dermatological and cosmetic formulations such as after shave creams, hand-and body-lotions, deodorants, lip sticks, sun-care and after-sun products, baby care products and sport creams [18]. It may be a preferred active ingredient for protection against the recurring stresses of the environment on the skin.…”

“…Bisabolol and bisabolol richoil have also demonstrated the capacity to enhance the percutaneous absorption of certain molecules and may prove to be an important ingredient for cosmetic and skin care products in the future [18,19].…”

Desenvolvimento e eficácia anti-inflamatória não-clínica de uma formulação anti-acne

“…Além de diminuir a produção de TNF- [36], também diminui a expressão da COX-2 [37]. α-(-)-Bisabolol, outro constituinte da Matricaria recutita, reduz a produção de citocinas pró-inflamatórias e diminui a inflamação da pele [38] promovida por diversos agentes [39].…”