Amperometric lactate oxidase catheter for real-time lactate monitoring based on thin film technology

l-lactate measures in brain tissue with ceramic-based multisite microelectrodes

“…More recently, it has been proposed that l-lactate can be produced by astrocytes in the brain and released into the extracellular space to form a pool readily available for neurons in case of high-energy demand (Hu and Wilson, 1997;Pellerin, 2003). Studies support that lactate shuttles between astrocytes al., 1998), and in blood (Gfrerer et al, 1998;Meyerhoff et al, 1993;Pfeiffer et al, 1997). Ultra-low volume microtiter chambers with integrated microelectrodes have been utilized to measure l-lactate from single heart cells (Cai et al, 2002).…”

Amperometric determination of lactate with novel trienzyme/poly(carbamoyl) sulfonate hydrogel-based sensor

“…Biosensors employed different enzymes have been developed for lactate monitoring. Cytochrome b 2 (Amine et al, 1994;Bartlett and Caruana, 1994), lactate monooxygenase (Mascini et al, 1984), and LOD (Baker and Gough, 1995;Faridnia et al, 1993;Pfeiffer et al, 1997) have been used for this purpose. Bienzyme systems, such as LOD/LDH (Mizutani et al, 1985), cytochrome b 2 /LDH (Schubert et al, 1985) and glutamate pyruvate transaminase/LDH (Lobo-Castannon et al, 1997), have been investigated.…”

Self-Powered Electrochemical Lactate Biosensing

“…Based on the results obtained, the sensitivity was calculated to be 125.88 Hz/mM-cm 2 and a linear dynamic range of 1-100 mM lactic acid was observed with a linear correlation-regression coefficient of 0.9948. These results are higher in comparison to amperometric lactic acid biosensors previously reported [25,26]. The linear calibration curve was determined using the following equation:…”