Amphiphilic chitosan derivative-based core–shell micelles: Synthesis, characterisation and properties for sustained release of Vitamin D3

Li, Wenjian; Peng, Hailong; Ning, Fangjian; Yao, Lihua; Luo, Ming; Zhao, Qiang; Zhu, Xuemei; Xiong, Hua

doi:10.1016/j.foodchem.2013.11.147

Cited by 66 publications

(43 citation statements)

References 35 publications

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“…According to this model, the liquid penetrates the TMC matrix and dissolves the embedded antibiotics, and so the antibiotic release seems to be a process predominately controlled by diffusion. Similar drug release kinetics were reported for nanoparticles and micelles by Gandhi [15] and Li [16] Based on an "n" value (diffusion exponent) between 0.45 and 0.89, obtained from the Korsmeyer-Peppas model, we can conclude that the drug release was non-Fickian, following an anomalous transport type diffusional release, which exhibited both diffusion-and swelling-controlled drug release. Furthermore, aside from matrix degradation possibly playing a small role, the data are in accordance with that previously described in the Higuchi model.…”

Section: In Vitro Drug Release and Kinetic Modelingsupporting

confidence: 82%

“…Accumulative release of the antibiotic followed a steady, continued-release pattern, without a burst release phenomenon, and the time for 50 and 80 wt % release was close to day 14 and day 32 respectively, which satisfied the need for prolonged administration of antibacterial agents after surgical debridement for about 4-6 weeks [14]. To predict and correlate the release of solutes from nanoparticles in vitro, results must be fit into a suitable mathematical model [15,16]. As presented in Figure 8, the data was most suited to the Higuchi model, with a correlation coefficient of 0.9939.…”

Section: In Vitro Drug Release and Kinetic Modelingmentioning

confidence: 84%

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Preparation and Evaluation of Vancomycin-Loaded N-trimethyl Chitosan Nanoparticles

Shou³

et al. 2015

Polymers

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Chronic intracellular infections caused by drug-resistant pathogens pose a challenge to the treatment of chronic osteomyelitis. Such treatment requires an intracellular delivery system for the sustained release of antibiotics such as vancomycin (VCM), which is an antibiotic of last resort used against many clinically resistant bacteria. In this work, we report VCM-loaded N-trimethyl chitosan (TMC) nanoparticles and their potential application for drug delivery. The results showed that the prepared nanoparticles were predominantly spherical in shape with an average particle diameter of 220 nm, a positive zeta potential, and a loading efficiency of 73.65%˘1.83%. Furthermore, their drug release profile followed the Higuchi model for sustained release, with non-Fickian diffusion. Over a 24-h period, 6.51%˘0.58% of the drug within the optimized nanoparticles was released. In vitro cytology showed that osteoblasts (OBs) exhibited higher alkaline phosphatase activity (ALP) after exposure to TMC nanoparticle material. Furthermore, TMC nanoparticles increased the uptake of water-soluble quantum dots (QDs) by OBs, and both nanoparticles and VCM/TMC mixtures improved OB proliferative activity. We also investigated the minimum inhibitory concentration (MIC, 60 µg/mL), half maximal inhibitory concentration (IC50, 48.47 µg/mL), diameter of inhibition zone (DIZ, 1.050 cm), Polymers 2015, 7 1851 and turbidimetric (TB) assay of nanoparticles. All data demonstrated that VCM/TMC nanoparticles had excellent antibacterial activity against the Gram-positive bacterium Staphylococcus aureus. These findings suggest that VCM-loaded TMC nanoparticles have good potential for the sustained delivery of antibiotics to bone infections.

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Section: In Vitro Drug Release and Kinetic Modelingsupporting

confidence: 82%

Section: In Vitro Drug Release and Kinetic Modelingmentioning

confidence: 84%

Preparation and Evaluation of Vancomycin-Loaded N-trimethyl Chitosan Nanoparticles

Shou³

et al. 2015

Polymers

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“…These nanosystems will allow maintaining the physical and chemical stability of VD, protecting the molecule from extreme temperatures, light, and oxygen that food and pharmaceutical products may be exposed to. MTT assay [40] Nanoemulsion Food and beverage fortification DLS, stability n/a n/a [41] Note that n/a stands for not applicable, AFM for atomic force microscopy, DLS for dynamic light scattering (used for size determination), DSC for differential scanning calorimetry, EE for NPs encapsulation efficiency, ELS for electrophoretic light scattering (used for zeta potential determination), FTIR for Fourier transform infrared spectroscopy, NMR for nuclear magnetic resonance, PBS for phosphate buffered saline, SEM for scanning electron microscope, SGF for simulated gastrointestinal fluid, TEM for transmission electron microscope and XRD for X-ray diffraction. SRB is a cellular proliferation assay (colorimetric) and MTT is cellular viability assay (colorimetric).…”

Section: Nanoparticles For the Encapsulation Of Vitamin Dmentioning

confidence: 99%

“…The prepared micelles also exhibited a biphasic release profile, with an initial rapid release, followed by a sustained release. The cytotoxicity of the nanocarrier was assessed using fibroblast mouse cells, and the results showed that the chitosan micelles had low cytotoxicity against the studied cell lines, proving to be biocompatible [41].…”

Section: Nanoparticles For the Encapsulation Of Vitamin Dmentioning

confidence: 99%

Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities

Ramalho¹,

Coelho²,

Pereira³

2017

A Critical Evaluation of Vitamin D - Clinical Overview

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In addition to the traditional role of calcium homeostasis and bone mineralization, calcitriol, the active metabolite of vitamin D, also displays other metabolic activities as antiproliferative, pro-differentiating, anti-inflammatory, immunomodulatory, and antineoplastic effects. Thus, the awareness that vitamin D insufficiency/deficiency may be associated with various diseases has grown. Also nowadays, vitamin D is recognized as a potential therapeutic agent in anticancer therapy. However, its administration presents some drawbacks such as high toxicity and low bioavailability. Thus, the use of nanotechnology may overcome these problems associated with vitamin D administration, allowing to decrease its toxicity in healthy tissues and increasing its bioavailability. In this chapter, an overview on vitamin D and its metabolic activity is presented, as well as a review of nanosystems for the encapsulation of vitamin D for different applications, such as food and pharmaceutical industries.

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“…About 1.0 mL of oleoyl chloride and 4.0 M of sodium hydroxide was added to the resulting solution and reacted for 1.5 hours. DCMCs was prepared according to a procedure outlined by Li et al [9] with some modifications. A mixture of 2.0 mL epichlorohydrin and 5.0 mL of N,N-dimethylhexadecylamine were added and stirred for 2 hours at 50 °C.…”

Section: Preparation Of Ocmcs Dcmcs and Dacmcsmentioning

confidence: 99%

Amphiphilic chitosan derivatives as carrier agents for rotenone

Kamari

Aljafree

2017

AIP Conference Proceedings

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Abstract.In the present study, the feasibility of amphiphilic chitosan derivatives, namely oleoyl carboxymethyl chitosan (OCMCs), N,N-dimethylhexadecyl carboxymethyl chitosan (DCMCs) and deoxycholic acid carboxymethyl chitosan (DACMCs) as carrier agents for rotenone in water-insoluble pesticide formulations was investigated. Fourier Transform Infrared (FTIR) Spectrometer, CHN-O Elemental Analyser (CHN-O) and Transmission Electron Microscope (TEM) were used to characterise amphiphilic chitosan derivatives. The critical micelle concentration (CMC) of amphiphilic chitosan derivatives was determined using a Fluorescence Spectrometer. A High Performance Liquid Chromatography (HPLC) was used to determine the ability of OCMCs, DCMCs and DACMCs to load and release rotenone in an in vitro system. Based on TEM analysis, results have shown that amphiphilic chitosan derivatives formed self-assembly and exhibited spherical shape. The CMC values determined for OCMCs, DCMCs and DACMCs were 0.093, 0.098 and 0.468 mg/mL, respectively. The encapsulation efficiency (EE) values for the materials were more than 97.0%, meanwhile the loading capacity (LC) values were greater than 0.90%. OCMCs, DCMCs and DACMCs micelles exhibited an excellent ability to control the release of rotenone, of which 90.0% of rotenone was released within 40 to 52 h. In conclusion, OCMCs, DCMCs and DACMCs possess several key features to act as effective carrier agents for rotenone. Overall, amphiphilic chitosan derivatives produced in this study were successfully increased the solubility of rotenone by 49.0 times higher than free rotenone.

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Amphiphilic chitosan derivative-based core–shell micelles: Synthesis, characterisation and properties for sustained release of Vitamin D3

Cited by 66 publications

References 35 publications

Preparation and Evaluation of Vancomycin-Loaded N-trimethyl Chitosan Nanoparticles

Preparation and Evaluation of Vancomycin-Loaded N-trimethyl Chitosan Nanoparticles

Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities

Amphiphilic chitosan derivatives as carrier agents for rotenone

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