Amphotericin B liposome-induced acrocyanosis and elevated serum creatinine

Abstract

A 77-year-old male patient developed acrocyanosis and pain after treatment with amphotericin B liposome 150 mg daily intravenously for disseminated histoplasmosis, and subsequently developed elevated serum creatinine. Amphotericin B liposome was discontinued, and anisodamine was used intravenously to treat acrocyanosis and pain induced by amphotericin B liposome for 9 days and patient was cured. Naranjo adverse drug reaction probability scale score was 5, the World Health Organization-Uppsala Monitoring Centre criteria: Probable, indicating a probable adverse reaction to amphotericin B liposome.

Acrocyanosis – A Symptom with Many Facettes

“…Liposomal amphotericin-B and amphotericin-B deoxycholate used for the treatment of systemic fungal infections have been reported to cause acrocyanosis that was reversible after discontinuation [ 32 ][ 33 ].…”