1988
DOI: 10.1016/0002-9343(88)90059-9
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Amphotericin B-resistant yeast infection in severely immunocompromised patients

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Cited by 213 publications
(103 citation statements)
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“…Most of the resistant isolates to amphotericin B were recovered from immunocopromised individuals and this could be related to effects on cellular membrane of yeast, in relation to the multiple treatments received for these patients. 40 In general, resistance to amphotericin B because of previous exposure to this drug has not been detected. Pfaller et al [41] described different proportion of resistance to amphotericin B according to Candida strains considered, with 5% of C. albicans, 59% of C. glabrata and 100% to C. krusei resistant to amphotericin B.…”
mentioning
confidence: 99%
“…Most of the resistant isolates to amphotericin B were recovered from immunocopromised individuals and this could be related to effects on cellular membrane of yeast, in relation to the multiple treatments received for these patients. 40 In general, resistance to amphotericin B because of previous exposure to this drug has not been detected. Pfaller et al [41] described different proportion of resistance to amphotericin B according to Candida strains considered, with 5% of C. albicans, 59% of C. glabrata and 100% to C. krusei resistant to amphotericin B.…”
mentioning
confidence: 99%
“…Most infections appear to originate from the patients' alimentary tract microflora (32). The higher proportion of C. tropicalis in adult patients and older children hospitalized in oncology-hematology units might be partially explained by the prophylactic or empirical use of amphotericin B (23). However, other differences, such as host defense deficiency and mucosal integrity, may be related to this discrepancy.…”
mentioning
confidence: 99%
“…It has long been documented that polyene-resistance emerged under therapy of immunosuppressed patients with Amphothericin B [99][100][101][102][103][104][105][106][107]. Recently, C. albicans strains were isolated consecutively from biopsies and faeces of an immunocompromised patient which acquired stepwise resistances to Azoles, Echinocandins, and Amphothericin B [108].…”
Section: Polyene Resistance Recovered From Patients Treated Either Wimentioning
confidence: 99%