Amylase-Producing Multiple Myeloma

Matsuzaki, Hiromitsu; Takatsuki, Kiyoshi

doi:10.1007/978-3-642-76655-8_24

Cited by 9 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Structural alterations and rearrangements involving chromosome 1 near the amylase locus were observed [9,12,13] and it seems possible that the amylase gene might be activated by an oncogene [10]. Such alterations induce an uncontrolled production of amylase by plasma cells, leading to elevated serum amylase.…”

Section: Discussionmentioning

confidence: 98%

Amylase: A disease activity index in multiple myeloma?

Pinelli

Bindi

Rosada

et al. 2006

Leukemia & Lymphoma

View full text Add to dashboard Cite

This study reports a case of a patient with lambda-light chain multiple myeloma who developed a high hyperamylasaemia of the salivary type during the disease and soon afterwards died. Ectopic production of amylase by myeloma cells has been described in a few cases and demonstrated by tissue culture and immunohistochemical techniques. The common characteristics of these cases were: salivary amylase isoenzyme increase, high tumor mass, extensive extra-medullary spread, extensive bone destruction and poor prognosis. In patients with amylase-producing multiple myeloma, the onset of hyperamylasaemia heralds a rapid disease progression; therefore, in these patients, a simple test such as serum amylase may represent a reliable disease activity index and provide an additional prognostic information.

show abstract

Section: Discussionmentioning

confidence: 98%

Amylase: A disease activity index in multiple myeloma?

Pinelli

Bindi

Rosada

et al. 2006

Leukemia & Lymphoma

View full text Add to dashboard Cite

show abstract

“…Ectopic amylase production is even rarer, with only 8 patients with multiple myeloma (MM) [7][8][9][10] and 1 more with monoclonal gammapathy of undetermined significance [11 ] being reported. Ail of these patients but 1 (No.…”

Section: Introductionmentioning

confidence: 99%

Amylase-Producing Bence Jones Multiple Myeloma with Pancreatitis-Like Symptoms

López

Ulibarrena²,

González-Porqué³

et al. 1993

Acta Haematol

View full text Add to dashboard Cite

Amylase-producing tumors are mainly adenocarcinomas and, in rare instances, multiple myelomas. We describe here a first case of amylase-producing Bence Jones type myeloma with pancreatitis-like symptoms and the second in a Caucasian patient. The finding of salivary-type hyperamylasemia in a 72-year-old female with a possible pancreatitis made us suspect the diagnosis. Amylase production was observed in bone marrow cultures in which 96% of cellularity was composed of plasmablasts. Serum amylase level decreased when chemotherapy was given.

show abstract

“…IL-6 find ings at the time of diagnosis also serve as a prognostic fac tor [5] although its action in an autocrine or a paracrine fashion remains controversial [6,7], Other investigators reported that bone marrow myeloma cells are producing IL-lp and/or TNF and that the severity of bone lesions was closely correlated with these cytokines [8], Hata et al [9] first reported a case of IgA-7, type multiple myeloma whose serum salivary type amylase is elevated and dem onstrated that the myeloma cells are producing the sali vary type amylase. Afterwards, Matsuzaki and Takatsuki [10] reported 6 cases of amylase-producing multiple my eloma. These substances such as cytokines and salivary type amylase produced by myeloma cells may also be come useful tumor markers in plasma cell dyscrasias.…”

Section: Discussionmentioning

confidence: 99%

Increased Serum CA125 Levels in Plasma Cell Dyscrasias

Iwasaki

Hamano²,

Aizawa³

et al. 1997

Acta Haematol

View full text Add to dashboard Cite

We report 2 cases of plasma cell dyscrasia presenting with significantly elevated serum CA125 levels. The serum levels of CA125 from these patients correlated well with their serum M-protein levels. One patient had an IgG-ĸ type extramedullary plasmacytoma with the culture supernatant from lymph node plasma cells showing a considerably high level of CA125 activity. The serum IgG fraction purified using a protein A column was devoid of any detectable CA125 activity, negating that the serum IgG M-protein from this patient might respond with a false-positive result in the CA125 immunoradiometric assay. The other patient had an IgG-λ type plasma cell leukemia with the culture supernatant from peripheral mononuclear cells also showing a high level of CA125 activity. These observations may suggest that in plasma cell dyscrasias the CA125 antigen is spontaneously produced by tumor cells.

show abstract

Amylase-Producing Multiple Myeloma

Cited by 9 publications

References 33 publications

Amylase: A disease activity index in multiple myeloma?

Amylase: A disease activity index in multiple myeloma?

Amylase-Producing Bence Jones Multiple Myeloma with Pancreatitis-Like Symptoms

Increased Serum CA125 Levels in Plasma Cell Dyscrasias

Contact Info

Product

Resources

About