Amyloid β-induced erythrocytic damage and its attenuation by carotenoids

Nakagawa, Kiyotaka; Kiko, Takehiro; Miyazawa, Taiki; Sookwong, Phumon; Tsuduki, Tsuyoshi; Satoh, Akira; Miyazawa, Teruo

doi:10.1016/j.febslet.2011.03.060

Cited by 47 publications

(60 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exposure of RBCs exposed to Aβ on the luminal surface of cerebral microvessels induces the erythrocytes' adhesion to endothelial cells and affects endothelial functionality [68] [69]. In agreement with these notions, Down syndrome patients with elevated Aβ levels in blood plasma were reported to have a greater risk of developing AD [70,71].Oxidative stress & altered energy production in RBCs Aβ binding induces oxidative injury to RBCs and causes the accumulation of phospholipid hydroperoxides, a specific marker for RBC membrane oxidative injury [72]. Moreover, an inverse relationship was seen between RBC concentrations of phospholipid hydroperoxides and carotenoids in AD patients [72].…”

supporting

confidence: 59%

“…Moreover, an inverse relationship was seen between RBC concentrations of phospholipid hydroperoxides and carotenoids in AD patients [72]. Erythrocytes do not have sufficient mechanisms to repair oxidized lipids in their membranes, which leads to the accumulation of these products in the membranes as well as inside the cell during the erythrocyte's lifespan.…”

Section: Aβ-induced Morphological Changes In Erythrocytesmentioning

confidence: 97%

“…Oxidative stress & altered energy production in RBCs Aβ binding induces oxidative injury to RBCs and causes the accumulation of phospholipid hydroperoxides, a specific marker for RBC membrane oxidative injury [72]. Moreover, an inverse relationship was seen between RBC concentrations of phospholipid hydroperoxides and carotenoids in AD patients [72].…”

Section: Aβ-induced Morphological Changes In Erythrocytesmentioning

confidence: 99%

See 2 more Smart Citations

Search for Alzheimer's Disease Biomarkers in Blood Cells: Hypotheses-Driven Approach

et al. 2017

View full text Add to dashboard Cite

Current Alzheimer's disease (AD) diagnostics is based on cognitive testing, and detecting amyloid Aβ and τ pathology by brain imaging and assays of cerebrospinal fluid. However, biomarkers identifying complex pathways contributing to pathology are lacking, especially for early AD. Preferably, such biomarkers should be more cost-effective and present in easily available diagnostic tissues, such as blood. Here, we summarize the recent findings of potential early AD molecular diagnostic biomarkers in blood platelets, lymphocytes and erythrocytes. We review molecular alterations which refer to such main hypotheses of AD pathogenesis as amyloid cascade, oxidative and mitochondrial stress, inflammation and alterations in cell cycle regulatory molecules. The major advantage of such biomarkers is the potential ability to indicate individualized therapies in AD patients. Alzheimer's disease (AD) is the most prevalent age-related dementia worldwide and one of the major unmet, increasing medical and economic problems of the modern world. As of 2015, there were an estimated 46.8 million people with dementia worldwide. This number will increase to an estimated 74.7 million in 2030 [1].Among the neuropathological hallmarks of AD are: the progressive loss of brain neurons, synaptic degeneration and the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles (NFTs) in such regions of the brain as the hippocampus, cortex and amygdala. Amyloid plaques consist mainly of 40-and 42-amino-acid Aβ peptides (Aβ40 and Aβ42). Peptides are proteolytic cleavage products of the Aβ protein precursor (APP) but with no fully elucidated biological function. NFTs are deposits of paired helical filaments composed mainly of hyperphosphorylated τ protein, a microtubule-stabilizing protein that maintains neuronal cell structure and axonal transport. Nevertheless, neither senile plaques nor NFTs are absolute hallmarks of AD dementia, because cognitively intact aged individuals may exhibit both pathological changes upon postmortem brain examination or as assessed by positron emission tomography amyloid and τ imaging agents (amyloid-PET and τ-PET) [2][3][4][5].Clinical AD manifests by aggravating dysfunction and weakening functional cognitive processes, linked to brain neuron loss that is both progressive and permanent [4], and that within several years leads to total dependence on the caregiver and eventually to death. Advances in our knowledge of AD have shown that clinical symptoms usually develop after a long preclinical pathogenic process, lasting for decades, making early AD detection in asymptomatic patients a subject of great interest [4,5]. Increasing proof demonstrates that the therapeutic methods' effectiveness is strictly contingent on the early diagnosis of AD, before the occurrence of massive neuron loss and dementia. This highlights the key importance of biochemical biomarkers for early AD diagnostics. AD diagnostics & demand for novel, improved biomarkersThe broadly accepted recommendations for AD diagnosis...

show abstract

supporting

confidence: 59%

Section: Aβ-induced Morphological Changes In Erythrocytesmentioning

confidence: 97%

Section: Aβ-induced Morphological Changes In Erythrocytesmentioning

confidence: 99%

See 1 more Smart Citation

Search for Alzheimer's Disease Biomarkers in Blood Cells: Hypotheses-Driven Approach

et al. 2017

View full text Add to dashboard Cite

show abstract

“…L supplementation has been shown to improve verbal fluency in older women , and plasma carotenoid levels have been associated with performance across a range of cognitive domains (Akbaraly et al, 2007) as well as being lower in individuals with mild cognitive impairment and Alzheimer's disease (AD) compared with normal controls (Rinaldi et al, 2003). Xanthophylls can attenuate the inflammatory effect of Aβ on the vasculature, thus potentially reducing the risk of AD (Nakagawa et al, 2011). Furthermore, the concentration of Z in blood serum is inversely associated with the severity of white matter lesions in the brains of nondemented older adults (den Heijer et al, 2001).…”

mentioning

confidence: 99%

Low macular pigment optical density is associated with lower cognitive performance in a large, population-based sample of older adults

Feeney

Finucane

Savva

et al. 2013

Neurobiology of Aging

124

View full text Add to dashboard Cite

Macular pigment (MP) is comprised of the carotenoids lutein (L), zeaxanthin (Z), and meso--zeaxanthin (MZ), which selectively accumulate at the macula (central retina) of the eye and are neuroprotective. These carotenoids are also present in the brain, and evidence suggests a close correlation between retinal and brain concentrations. We investigated the relationship between MP and cognitive function in 4453 adults aged ≥50 years as part of The Irish Longitudinal Study on Aging. Macular pigment optical density (MPOD) was determined using customized heterochromatic flicker photometry-a quick and noninvasive way of measuring the concentration of the pigment. Lower MPOD was associated with poorer performance on the mini--mental state examination (p = 0.026) and on the Montreal cognitive assessment (p = 0.016). Individuals with lower MPOD also had poorer prospective memory (p = 0.011), took longer time to complete a trail--making task (p = 0.003), and had slower and more variable reaction times on a choice reaction time task (p = 0.000 and 0.001). These associations were only slightly attenuated following adjustment for physical and mental health. There was no significant association between MPOD and verbal fluency, word recall, visual reasoning, or picture memory. Overall, the findings support the theory that xanthophyll carotenoids impact on cognitive function, underscoring the need for exploration of novel, noninvasive biomarkers for cognitive vulnerability and preventive strategies.

show abstract

“…In our murine study 10 , oral administration of a lutein concentrate showed its incorporation into erythrocytes and distribution in the phospholipid bilayers. This treatment resulted in decreased erythrocyte PLOOH levels.…”

Section: Introductionmentioning

confidence: 99%

Ingestion of Chlorella Reduced the Oxidation of Erythrocyte Membrane Lipids in Senior Japanese Subjects

Miyazawa¹,

Nakagawa²,

Takekoshi³

et al. 2013

J. Oleo Sci.

Self Cite

View full text Add to dashboard Cite

Amyloid β-induced erythrocytic damage and its attenuation by carotenoids

Cited by 47 publications

References 29 publications

Search for Alzheimer's Disease Biomarkers in Blood Cells: Hypotheses-Driven Approach

Search for Alzheimer's Disease Biomarkers in Blood Cells: Hypotheses-Driven Approach

Low macular pigment optical density is associated with lower cognitive performance in a large, population-based sample of older adults

Ingestion of Chlorella Reduced the Oxidation of Erythrocyte Membrane Lipids in Senior Japanese Subjects

Contact Info

Product

Resources

About