An alternative approach to wound healing field; new composite films from natural polymers for mupirocin dermal delivery

Abstract

In this study, novel adhesive films were prepared for Mupirocin dermal delivery. Natural polymers as chitosan, sodium alginate and carbopol were used for films development to evaluate possible interactions and drug release properties. Solvent evaporation method was used for films preparation. Preliminary studies involved FT-IR spectroscopy and Scanning Electron Microscopy to specify interactions and morphology. Thickness, tensile strength and water uptake in phosphate buffer saline were evaluated whereas in vitro release studies were also performed. In vitro drug release studies demonstrated that mupirocin release was improved. Ex vivo bioadhesion and permeation studies using Balb-c mice were performed to check the suitability of the films. Antimicrobial ability was evaluated by agar well diffusion tests. Finally, excisional wound model applied to test the wound healing effect and evaluated macroscopic and histopathologically. One formulation was found more effective compared to the market product for wound healing at Balb-c mice.

Formulation and Detailed Characterization of Voriconazole Loaded in Situ Gels for Ocular Application

“…If the standard deviation less than the acceptance criteria which is 2%, the analysis system for the determination of assay is to verify [27]. The LOD and LOQ tests for the procedure were performed on samples containing very low concentrations of analyses [28]. The LOD and LOQ were determined as 0.022 μg/mL and 0.065 μg/mL, respectively.…”

The advances in human oral biology and biotechnology

“…Current knowledge says that they can transport biological molecules in their original, intact and active form, including nucleic acids and proteins. This discovery makes it possible to claim that they are load-bearing elements that are part of the intercellular signaling pathways that are not fully understood [52][53][54][55][56][57][58][59][60]. Moreover, not only exosomes isolated from cells have extraordinary properties.…”

New Dosage Forms: Oral Films

“…Kopma anındaki kuvvet kaydedilerek gerilme direnci, uzama yüzdesi ve elastik modülü formüller yardımıyla hesaplanır. 24 Ağızda dağılan dozaj formlarının çözünme hızı (dissolüsyon) çalışmalarında uygulanan resmi bir metot olmadığından, literatürde 5-900 mL'lik farklı hacimlerde farklı aparatlar (farmakope ya da özel yapım) farklı pH tamponları ya da yapay tükürük, gastrik ya da intestinal sıvıda yapılan çalışmalar bildirilmiştir. 38 Çözünme hızı çalışmalarının standart sepet ya da palet aparatı kullanılarak gerçekleştirilebildiği, palet aparatı ile gerçekleştirildiğinde filmin çözünme ortamı üzerinde yüzebileceği bildirilmiştir.…”