No abstract

Ocular allergy is one of the most common disorders of the eye surface. The conventional eye drops lack of therapeutic efficacy due to low ocular bioavailability and decreased drug residence time on eye surface. Hence, the present research work aimed to formulate, optimize, and evaluate the in situ gel for ophthalmic drug delivery. The prepared in situ gel formulations were evaluated for clarity, pH, gelling capacity, viscosity, osmolality, in vitro release study, and kinetic evaluation. ex vivo corneal permeation/penetration study using goat and in vivo studies on rabbits were also performed. Fourier‐transformed infrared spectroscopy was also applied to study possible interactions between drug and polymers. The formulations found to be stable, nonirritant, and showed sustained release of the drug for a period of up to 24 hr with no ocular damage. The developed in situ gels loaded with tetrahydrozoline are alternative and promising ocular candidates for the treatment of allergic conjunctivitis.

No abstract

No abstract

The aim of the present study was to develop and validate a High-Performance liquid Chromatography (HPlC) method for the determination of voriconazole in drug substances and in situ gel. a mixture of acetonitrile and ultrapure water (50:50) (v/v) was used as mobile phase. The column was a C18 column (150x4.6mm with 5µm particles). The eluent was monitored with uV detection at 256 nm and flow rate was set to 1 ml/ min. The method was validated partially with respect to system suitability, linearity, limits of detection (lOd) and quantitation (lOQ), precision, accuracy, specificity, selectivity and stability. Obtained results showed that the analytical method had good linearity, accuracy, precision, selectivity and stability. analytical method development results indicated that the lOd was 0.022 µg/ml; lOQ was 0.065 µg/ml and assay exhibited a linear range of 1-30 µg/ml.