Evaluation of burn wound healing activity of novel fusidic acid loaded microemulsion based gel in male Wistar albino rats

Formulation, Optimization, and Evaluation of Oregano Oil Nanoemulsions for the Treatment of Infections Due to Oral Microbiota

“…Similar findings were repeatedly reported in the literature. 34,35 Another interesting observation was the significant effect of factor C (HLB of S mix ) and its quadratic term C 2 on the droplet size of the NEs. As shown in Figure 2A, this meant that the peripheral levels of factor C had a positive effect on the globule size, whereas the middle level had a negative effect, causing the formation of smaller droplets.…”

Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application

“…Its bioavailability is rate-limited with its dissolution and it is a Biopharmaceutics Classification System (BCS) Class-II drug [4]. It is formed in numerous formulations for oral (suspension and tablet), topical (cream and ointment), and intravenous administration [19]. Commercial ocular formulations of FA are widely used for the topical treatment of bacterial conjunctivitis [20].…”

Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

“…Multiple applications in biomedical field were hypothesized and studied considering as effective the delivery of microemulsions in the human body. Several discoveries with positive results can be mentioned: in ophthalmology [23], for ocular delivery of retinol [24] or sacha inchi oil for dry eye treatment [25]; intranasal delivery for zidovudine [26]; sublingual delivery of insulin [27]; application of fusidic acid in wound healing [28]; vaginal delivery for fluconazole [29]; transdermal drug delivery [30]; cosmetics [31]; self-microemulsifyied systems with in situ generation of Numerous therapeutic approaches were initiated to enhance the bioavailability of dermatologic drugs at skin site in the hope to overcome the barrier effect of stratum corneum. The avoidance of oral administration of systemic drugs is also pursued, as well as attempts to integrate them in topical formulations [13].…”

“…Multiple applications in biomedical field were hypothesized and studied considering as effective the delivery of microemulsions in the human body. Several discoveries with positive results can be mentioned: in ophthalmology [ 23 ], for ocular delivery of retinol [ 24 ] or sacha inchi oil for dry eye treatment [ 25 ]; intranasal delivery for zidovudine [ 26 ]; sublingual delivery of insulin [ 27 ]; application of fusidic acid in wound healing [ 28 ]; vaginal delivery for fluconazole [ 29 ]; transdermal drug delivery [ 30 ]; cosmetics [ 31 ]; self-microemulsifyied systems with in situ generation of microemulsion in biological fluids for oral delivery [ 32 ]. In topical therapy of dermatologic conditions, an increased solubility and bioavailability was obtained for molecules like: cyclosporine in psoriasis [ 33 ]; ceramides for skin restructuration [ 34 ]; imiquimod in actinic keratosis or basal cell carcinoma [ 35 ]; penciclovir [ 36 ], acyclovir for herpes virus simplex cutaneous infection [ 37 ]; and tenoxicam for arthritis alleviation [ 38 ].…”