An analysis of structural, spectroscopic signatures, reactivity and anti-bacterial study of synthetized 4-chloro-3-sulfamoylbenzoic acid

Kavitha, C.; Narendra, K.; Ratnakar, A.; Nuthalapati, Poojith; Sampath, C.; Banik, Subrata; Suchetan, P.A.; Potla, Krishna Murthy; Naidu, Nuthalapati Venkatasubba

doi:10.1016/j.molstruc.2019.127176

Cited by 11 publications

(2 citation statements)

References 68 publications

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“…Essential characterizations were conducted to assess their chemical and phase purity. The 1 H NMR spectra of these two products were determined (Figure S1) and the peaks were calibrated. , The results show that in addition to the original components, very small amounts of solvents were present in both products. The peaks corresponding to methyl on acetone (δ = 2.08) and methanol (δ = 3.17) were individually quantified.…”

Section: Resultsmentioning

confidence: 99%

Green Mechanochemical Preparation of Cocrystal Polymorphs: Significant Effect of Intermediates and Solvents

Qi,

Li,

Cheng

et al. 2024

Crystal Growth & Design

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Recently, green mechanochemical methods have received increasing attention. The fact that intermediates may exist during the milling process has also been gradually revealed. However, it is still unclear whether the modulation of the product polymorphs or the search for new polymorphs can be achieved by changing the intermediates. Herein, the modulation of the intermediates was successfully achieved by varying raw materials to explore the impact of intermediates on products, focusing on 4-chloro-3-sulfamoylbenzoic acid (CSBA), isonicotinamide (INA), and their cocrystals. The solvents and intermediates were revealed to have a decisive influence on the forms of products. A new CSBA−INA 1:1 cocrystal polymorph (form III) was discovered by changing intermediates, and its synthon was identified. The selected solvents were categorized into three groups based on the solubility data of CSBA and INA as well as the results of the milling experiments. When the second group of solvents was added, depending on the raw materials, CSBA−INA 1:1 form I could be obtained directly or form II/III could be obtained through the intermediate of a mixture of CSBA−INA 1:2 and 2:1. The mechanisms by which raw materials and solvents from different categories affect the intermediates and, consequently, the form of the products were elaborated. Ultimately, the alteration in the product form was attributed to a combination of the synthons in the intermediates and the stabilizing effect of the solvents on the crystals.

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Section: Resultsmentioning

confidence: 99%

Green Mechanochemical Preparation of Cocrystal Polymorphs: Significant Effect of Intermediates and Solvents

Qi,

Li,

Cheng

et al. 2024

Crystal Growth & Design

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“…Sulphonamides commonly referred to by many as 'sulfa drug' were the first therapeutic agents extensively used directly or indirectly as preventive and chemotherapeutic drugs against numerous diseases [1]. A large number of drugs with the sulfonamide moiety are already in wide clinical use; as antihypertensive agents [2], antibacterial [3], antiprotozoal [4], antifungal [5], anti-inflammatory [6], nonpeptidic vasopressin receptor antagonists [7] and translation initiation inhibitors [8]. Furthermore, other vital sulphonamide derivatives have been used as carbonic anhydrase inhibitors of commercial importance [9], and are also effective for the treatment of urinary, intestinal and ophthalmic infections, scalds, ulcerative colitis [2], rheumatoid arthritis [2,10], male erectile dysfunction as the phosphodiesterase-5inhibitor Sildenafilbetter known under its commercial name, Viagra [2,11], and obesity [12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Antimicrobial Activity of N-Pyridin-3-yl-benzenesulfonamide

Ijuomah¹,

Ike²,

Obi³

2022

EJCS

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This study describes a simple one-pot synthesis of N-pyridin-3-yl-benzenesulfonamide and its antimicrobial activity. The reaction of benzene sulfonyl chloride with 3-aminopyridine in the presence of aqueous Na2CO3 and HCl as a scavenger furnished the sulfonamide in 93.3% yield. The structure of the synthesized compound was established using the spectral data obtained from FTIR, 1HNMR and 13CNMR). All spectrometric spectrum bands and peaks obtained were sulfonamide-related. The antibacterial test carried out against Gram-positive bacterium (Staphylococcus aureus) and Gram-negative bacteria (Salmonella typhi and Eschericha coli) tested upon at concentrations 150, 100, 50 and 25 mg/ml revealed that the synthesized N-pyridin-3yl-benzenesulfonamide possesses great antimicrobial activity.

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Effect of functional group position in co-formers and solvent on cocrystal polymorphism/stoichiomorphism: a case study

Chang²,

Bai

et al. 2023

Journal of Molecular Liquids

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An analysis of structural, spectroscopic signatures, reactivity and anti-bacterial study of synthetized 4-chloro-3-sulfamoylbenzoic acid

Cited by 11 publications

References 68 publications

Green Mechanochemical Preparation of Cocrystal Polymorphs: Significant Effect of Intermediates and Solvents

Green Mechanochemical Preparation of Cocrystal Polymorphs: Significant Effect of Intermediates and Solvents

Synthesis, Characterization and Antimicrobial Activity of N-Pyridin-3-yl-benzenesulfonamide

Effect of functional group position in co-formers and solvent on cocrystal polymorphism/stoichiomorphism: a case study

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