An analytic model of the dynamic response of mass-sensitive chemical sensors

Modeling the thermal stability of enzyme-based in vitro diagnostics biosensors

“…Detection technologies may vary, but are typically based on optical or electrochemical principles [2]. A variety of mathematical models have been developed for simulating and characterizing responses from enzyme-based biosensors [3][4][5][6] and from gravimetric biosensors [7][8][9]. These mathematical models generally describe three main processes: the diffusive characteristics of the sensor layers, the kinetics of substrate/active site binding, and the electrochemical reaction kinetics at the electrode.…”

“…These mathematical models generally describe three main processes: the diffusive characteristics of the sensor layers, the kinetics of substrate/active site binding, and the electrochemical reaction kinetics at the electrode. The models have been used to improve sensor response time [4,[7][8][9], to optimize important sensor design factors [3,7], or to identify conditions where the behaviour of the sensor changes [5]. Biosensor models are also necessary for converting the raw sensor response signal into an analytical value that quantifies the presence of analyte in the sample.…”

A2.1 - Modeling and Signal Processing Approaches for SAW Chemical Sensors

“…In many cases, the molecule diffusion is the dominant process and the reaction of the molecules at the binding sites can be neglected in comparison [10]. The solution of the reaction-diffusion equations under this assumption leads to a linear time-invariant (LTI) model for the sensor with c a (t) as input quantity and f m (t) as output quantity [11]. Therefore, the complete theory of LTI systems may be applied to SAW chemical sensors.…”

A Novel Method for Modelling a Thermopile Infrared Sensor in PSpice

“…Other models rely on the physical model in which the energy domains of the sensors are described by means of electrical equivalents [5].…”