An application of UV-derivative spectrophotometry and bivariate calibration algorithm for study of photostability of levomepromazine hydrochloride

Karpińska, Joanna; Sokół, Aneta; Skoczylas, Marta

doi:10.1016/j.saa.2008.06.007

Cited by 13 publications

(14 citation statements)

References 14 publications

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“…Hence, it was concluded that, the molar reactivity of the reaction is 0.67/0.58 which is equal to 1.15 and so the reaction proceeds in a ratio of 1:1. Based on the observed molar ratio, and depending on the presence of one primary amino group and by analogy to previous similar reports [12][13][14], the reaction pathway is postulated to proceed as shown in Figure 10.…”

Section: Stoichiometry and Mechanism Of The Reaction Of Oxy With Fluosupporting

confidence: 52%

Development and validation of second derivative and synchronous spectrofluorimetric methods for determination of oxytocin and ergometrine maleate in their combined formulation

2018

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Simple and sensitive second derivative and synchronous spectrofluorimetric methods have been developed and validated for the quantitative determination of oxytocin and ergometrine maleate in their pure and combined dosage forms. The methods are based on the derivatization reaction of oxytocin with fluorescamine reagent, which yielded a highly fluorescent compound measured at 486 nm after excitation at 390 nm. Ergometrine was directly measured in combination with oxytocin, since it exhibits native fluorescence at 421 nm after excitation at 300 nm. Quantitation of oxytocin in presence of ergometrine was also successful at 482 and 477 nm using second derivative and synchronous spectrofluorimetry, respectively. Different experimental parameters were studied and optimized. The relative fluorescence intensity versus concentration plot was rectilinear over the range of 0.04-0.75 and 5-100 ng/mL for oxytocin and ergometrine, respectively. The methods were successfully applied for the determination of both drugs in their prepared combined ampoules. The methods were validated and compared with the reference chromatographic method; they revealed good accuracy and reproducible results. The proposed methods showed high accuracy and sensitivity, with no requirement of multiple steps or previous chemical separation.Oxytocin Validation Dosage form Ergometrine maleate Synchronous spectrofluorimetry Second derivative spectrofluorimetry

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Section: Stoichiometry and Mechanism Of The Reaction Of Oxy With Fluosupporting

confidence: 52%

Development and validation of second derivative and synchronous spectrofluorimetric methods for determination of oxytocin and ergometrine maleate in their combined formulation

2018

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“…It can be applied for investigation of reaction kinetics [11,12], or for determination of chemical reaction constants.…”

Section: Table 2 Application Of Ds For Multicomponent Analysismentioning

confidence: 99%

“…First derivative spectra of levomepromazine (LV) and its sulphoxide were employed for investigation of LV photodegradation [11]. The degradation process of biapenem was monitored by measurement of first-derivative amplitude at 312 nm [12].…”

Section: Table 2 Application Of Ds For Multicomponent Analysismentioning

confidence: 99%

Basic Principles and Analytical Application of Derivative Spectrophotometry

Karpińska¹

2012

Macro to Nano Spectroscopy

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“…Uv-vis spectrophotometry can be used in pharmaceutical laboratories for a number of applications. [15][16][17][18][19][20][21] Few works have been found using this technique to determine antiretroviral fixed dose combinations. Uslu et al developed methods for the determination of AZT+3TC in binary mixtures, 22 using first derivate and first derivative of the ratiospectra Uv-spectrophotometry, as well as high performance liquid chromatography.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration

Grangeiro¹,

Albuquerque²,

Santana³

et al. 2011

Quím. Nova

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Recebido em 12/3/10; aceito em 17/11/10; publicado na web em 25/2/11The simultaneous determination of two or more active components in pharmaceutical preparations, without previous chemical separation, is a common analytical problem. Published works describe the determination of AZT and 3TC separately, as raw material or in different pharmaceutical preparations. In this work, a method using UV spectroscopy and multivariate calibration is described for the simultaneous measurement of 3TC and AZT in fixed dose combinations. The methodology was validated and applied to determine the AZT+3TC contents in tablets from five different manufacturers, as well as their dissolution profile. The results obtained employing the proposed methodology was similar to methods using first derivative technique and HPLC.

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An application of UV-derivative spectrophotometry and bivariate calibration algorithm for study of photostability of levomepromazine hydrochloride

Cited by 13 publications

References 14 publications

Development and validation of second derivative and synchronous spectrofluorimetric methods for determination of oxytocin and ergometrine maleate in their combined formulation

Development and validation of second derivative and synchronous spectrofluorimetric methods for determination of oxytocin and ergometrine maleate in their combined formulation

Basic Principles and Analytical Application of Derivative Spectrophotometry

Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration

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