An assessment of dynamic gastric scanning with 99Tcm-pertechnetate

Abstract

Following intravenous injection, technetium-99m (99Tcm) is selectively taken up by the stomach, and this uptake, which is stimulated by pentagastrin, may be quantified using a gamma camera. Using this property of 99Tcm as a means of assessing gastric function, we found that the mean rate of 99Tcm uptake was significantly greater in 24 duodenal ulcer patients than in 10 healthy controls (P less than 0.01). Scanning values did not correlate with BAO of MAO which were measured on a separate day. Both vagotomy (n = 10) and cimetidine infusion (n = 5) significantly reduced the rate of uptake of 99Tcm (P less than 0.01). Thus, although 99Tcm reflects a function of the stomach which is similar to acid secretion, scanning did not give a good estimate of acid secretion in this group of subjects.

Review article: methods of measuring gastric acid secretion

“…Use of 99m Tcpertechnetate scintigraphy as a method of measuring gastric acid was described in late 1970s. 74,75 Measurement of the accumulated 99m Tc-pertechnetate in the stomach by scintigraphy after intravenous injection of the tracer was thought to be related to gastric acid secretion. However, it used radioactive elements and doubts were expressed about its reliability so it has not been widely used.…”

Arginine–Arginine–Leucine Peptide Targeting Heat Shock Protein 70 for Cancer Imaging

“…After all, the peptide functional unit mostly contains at least five amino acids. In addition, imaging and biodistribution experiments have confirmed that 99m Tc-MAG 3 -RRL was mainly excreted mainly through the kidney and had obvious uptake in the stomach (Figure a and Supporting Table S4), which is possibly because of instability and nonspecific targeting. − Subsequently, we used VER-155008 to block HSP70. Our study demonstrated that the uptake of RRL can be inhibited by VER-155008 at the cellular and tissue levels.…”