An attempt to screen asymptomatic women for ovarian and endometrial cancer with transvaginal color and pulsed Doppler sonography.

Abstract

Several screening procedures have been proposed to detect ovarian and endometrial cancer. However, none of them is sensitive and specific enough to be used in population-based screening programs. During our 5 year long study, 5013 asymptomatic women (44% premenopausal and 56% postmenopausal women) were scanned by transvaginal color and pulsed Doppler ultrasonography in an attempt to detect malignancy. These women had 404 adnexal cysts; 70 had resolved spontaneously on follow-up scans and 18 persisted. Another 316 sonographically benign cysts are still in the procedure of follow-up second scans. Of 5013 women, four women had stage I ovarian carcinoma and six had stage I endometrial carcinoma. There was one false-positive case encountered with an endometrioma. Only 14 women were subjected to major operative intervention; others underwent minor procedures based on the benign scan findings. No medical or surgical complications were reported. Transvaginal color Doppler ultrasonography, a noninvasive procedure, can detect ovarian and endometrial carcinoma in asymptomatic women and may be used as a screening procedure for these diseases.

Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography

“…Intratumoral RI were found to be significantly lower than peritumoral RI 0.35 ± 0.09 and 0.66 ± 0.09 respectively; n = 23; P = 10 −8 ), as previously shown. 35 However, no significant difference in RI between control, SFV-LacZ and SFV-IL12-treated mice could be detected (Table 3).…”

Predicting Atypia Inside Endometrial Polyps

“…3). Atypia was suspected when the RI measured in the waveform at the level of these vessels had a value of less than 0.50, as arbitrarily proposed by Kurjak et al 7 on the basis of their work on neovascularization. 12 Hysteroscopy was performed with an Olympus 5.5-mm continuous flow office hysteroscope with a 5F working channel (Olympus Optical Co, Ltd, Tokyo, Japan).…”

“…[3][4][5][6] Since the late 1980s, transvaginal sonography has been enhanced by transvaginal color Doppler (TVCD) examination, allowing us to see and measure the vascularity of normal pelvic structures and to draw the vascular trees (color maps) of tumors, including EPs. 7,8 Some studies suggest that color flow Doppler imaging may assist in the diagnosis of endometrial carcinoma, because blood flow is increased in malignant lesions. 9,10 Some EPs show color maps reflecting functional activity.…”

Screening for Ovarian Cancer: Recommendation Statement

“…15 There is confl icting evidence as to whether adding color Doppler imaging to ultrasound screening can reduce the rate of false-positive test results. 16,17 There are few data to determine the sensitivity and specifi city of successive rounds of screening.…”