An audit of pain scores with conventional and white light topical 5‐methyl aminolaevulinic acid photodynamic therapy for superficial basal cell carcinoma and squamous cell carcinoma in situ

An open‐label prospective study to assess short incubation time white LED light photodynamic therapy in the treatment of superficial basal cell carcinoma

“…We previously compared pain scores in c‐PDT (n = 102) to awl‐PDT (n = 52) in the treatment of sBCC and SCCis. The median pain scores in the c‐PDT group were 43.75/100 (IQR 37.13) versus 0/100 (IQR 3.63) in the awl‐PDT group ( P < .001) 3 …”

“…The main drawback with conventional PDT (c‐PDT) is pain. A departmental audit on pain scores in our department showed that 33% of patients undergoing c‐PDT for sBCC experience severe pain 3 . Daylight PDT (dl‐PDT) using a modified protocol with short incubation times of MAL and continuous production of protoporphyrin IX (PpIX) shows comparable efficacy in the treatment of actinic keratosis (AK) and is almost pain free 4,5 .…”

“…A departmental audit on pain scores in our department showed that 33% of patients undergoing c-PDT for sBCC experience severe pain. 3 Daylight PDT…”

Photodynamic Therapy for Basal Cell Carcinoma: The Clinical Context for Future Research Priorities

“…A study of 223 sBCC, treated with either DL-PDT alone or with DL-MAL-PDT followed by imiquimod (IMQ), showed high mean response rates of 83.4% and 91.3%, respectively, after one year (p = 0.01) [72]; the full report on this study will be of interest. A cohort study recorded pain scores during the MAL-PDT treatment of 87 sBCC by different light deliveries [73]. Of these sBCC, 51 were treated with conventional MAL-PDT and 36 with a modified protocol using white light (LED, 75 J/cm 2 at 55 mW/cm 2 ); the time of exposure was varied by lesion size in the range of 83-93 min [73].…”

“…A cohort study recorded pain scores during the MAL-PDT treatment of 87 sBCC by different light deliveries [73]. Of these sBCC, 51 were treated with conventional MAL-PDT and 36 with a modified protocol using white light (LED, 75 J/cm 2 at 55 mW/cm 2 ); the time of exposure was varied by lesion size in the range of 83-93 min [73]. The white light treatment arm showed negligible pain, whereas the conventional PDT arm varied in the range of mild to severe pain; however, the potential of the development of artificial white light use in PDT is dependent on a demonstration of equivalency of lesion resolution in RCTs [73].…”