An Autopsy Case of Diffuse Panbronchiolitis Associated with Lung Cancer.

Ishioka, Shinichi; Hiyama, Keiko; Nishisaka, Takashi; Yokozaki, Michiya; Maeda, Hitoshi; Maeda, Akihiro; Jougasaki, Yasuyo; Yamakido, Michio

doi:10.2169/internalmedicine.39.404

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…DPB is a complex pulmonary disease that can be associated with many diseases, such as myasthenia gravis with thymoma, 11 rheumatoid arthritis, 12,13 lung cancer, 14 IgA nephropathy, 15 asthma [16][17][18] etc. To date, one case report of DPB complicated with asthma and bronchiectasis in a 48-year-old Irish woman on PubMed, 19 and one case report of DPB complicated with tuberculosis in a 12-year-old Chinese child on CNKI 20 have been published.…”

Section: Discussionmentioning

confidence: 99%

Diffuse panbronchiolitis: A case report from a Chinese consanguineous marriage family and literature review

Gong

Jiang

et al. 2020

Chron Respir Dis

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Diffuse panbronchiolitis (DPB) is a chronic diffuse airway inflammatory disease, which is strongly associated with the class I human leukocyte antigen (HLA) alleles. Here, we report a pair of sisters who have been suffering from chronic cough, expectoration and wheezing for many years. They were previously misdiagnosed as chronic bronchitis and bronchial asthma, and were recently diagnosed as diffuse panbronchiolitis. The 36-year-old elder sister suffered from diffuse panbronchiolitis complicated with pulmonary tuberculosis. The 30-year-old younger sister suffered from diffuse panbronchiolitis complicated with bronchial asthma and bronchiectasis. We have performed HLA genotyping research on the two sisters, their parents and younger brother. The results showed that all family members were positive for HLA-A24 and HLA-B13. The younger sister and mother were positive for HLA-A2. The younger brother and father were positive for HLA-A11. We suspect that the two sisters’ disease susceptibility may be caused by their parents’ consanguineous marriage. In this study, we reported the clinical characteristics of the two sisters with diffuse panbronchiolitis and shared the associated HLA genotyping results of this family cluster, hoping to provide reference for the etiology, diagnosis and treatment of this disease.

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Section: Discussionmentioning

confidence: 99%

Diffuse panbronchiolitis: A case report from a Chinese consanguineous marriage family and literature review

Gong

Jiang

et al. 2020

Chron Respir Dis

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Anti-inflammatory capabilities of macrolides

Zalewska-Kaszubska¹,

Górska²

2001

Pharmacological Research

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"Multi-effect" Macrolides

Narita

2000

Intern. Med.

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Until the late 1980' s, diffuse panbronchiolitis (DPB) (1) was recognized as a chronic small airway disease in the young-to middle-aged population with a poor prognosis in Japan. However, to date, most patients with DPBcan be improved and saved by long-term macrolides treatment. In this treatment, the 14-membered ring macrolides such as erythromycin (2) and clarithromycin (3, 4) are used. Considering it' s origin, this treatment was developed based on clinical evidence detected by a physician, however, it was not published as a case report. The clinical trials had been started in 1984 and were first reported in 1986 (5) and 1987 (6). Although long-term macrolide treatment was not accepted early, it is nowwell knownthat macrolides have anti-inflammatory mechanism (s) in addition to antibiotic effects. Clinical evidence and the recent progres

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An Autopsy Case of Diffuse Panbronchiolitis Associated with Lung Cancer.

Cited by 3 publications

References 4 publications

Diffuse panbronchiolitis: A case report from a Chinese consanguineous marriage family and literature review

Diffuse panbronchiolitis: A case report from a Chinese consanguineous marriage family and literature review

Anti-inflammatory capabilities of macrolides

"Multi-effect" Macrolides

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