An autoradiographic study of the dental lesions of lathyrism in the rat

Kennedy, Gregory D.; Kennedy, J. S.

doi:10.1016/0003-9969(63)90058-x

Cited by 10 publications

(10 citation statements)

References 12 publications

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“…Neither Dasler & Milliser (1957) nor McCallum (1958McCallum ( , 1965 examined the mouse periodontal ligament which this investigation proved to be a sensitive and reliable indieator of the onset of lathyrogenic changes. Although the rat is considered to be particularly susceptible to lathyrism with the rapid onset of gross and microscopic lesions (Menzies & Mills 1957, Tanzer 1965 the early appearance and types of lathyritic changes in the mouse periodontal ligament were similar to those reported in the mandibular periodontal ligament of rat molars (Gardner et al 1958, Krikos et al 1958, Gardner 1959, I960, Krikos 1959, Sciaky & Ungar 1961, Kennedy & Kennedy 1963, Sartiat & Seiaky 1965.…”

Section: Discussionmentioning

confidence: 55%

“…Eur-thermoie, the mice showed no clear evidence of mandibular exostoses which occur in rats (Selye 1957, Gardner et al 1958, Krikos et al 1958and Kennedy & Kennedy 1963. Deformation of molar apices (Gardner et al 1958, Kennedy & Kennedy 1963 and the abnormal incisor configuration recorded in rats (Gardner 1959, Sarnat Fig. 15.…”

Section: Discussionmentioning

confidence: 97%

“…There was a lack of the paresis reported by Menzies & Mills (1957) and Selye (1957) and, unlike the observations of Dasler & Milliser (1957) and Krikos et al (1958), a reduction occurred in mandibular size. Eur-thermoie, the mice showed no clear evidence of mandibular exostoses which occur in rats (Selye 1957, Gardner et al 1958, Krikos et al 1958and Kennedy & Kennedy 1963. Deformation of molar apices (Gardner et al 1958, Kennedy & Kennedy 1963 and the abnormal incisor configuration recorded in rats (Gardner 1959, Sarnat Fig.…”

Section: Discussionmentioning

confidence: 97%

“…The presence of amotphous lesions in mice is also a constant finding in the periodontal ligarncnt of rat molars. In rats these lesions are described in various ways such as homogeneous eosin-staining material resemblitig hyalin and osteoid (Gatdner et al 1958), amotphous eosinophilic material (Krikos et al 1958(Krikos et al , 1965, hyalin lakes and lathytitic bodies (Gardner 1959), altered eollagen (Gardner 1960), lakes of intercellular material (Kennedy & Kennedy 1963) and homogeneous hyalin-like masses (Sarnat & Sciaky 1965). As with Gardner's (1960) study of rats a variety of staining methods failed to indicate the nature of the amotphous lesions in the mouse although the lesions gave a positive reaction for eollagen with van Gieson.…”

Section: Oxl Dmentioning

confidence: 99%

“…Although Lewis & lieved that oxytalan fibers are related to Schulert (1949) were unable (o demonstrate elastie fibers (Fullmer 1960, Fullmer et al lathyrism in white mice, Dasler & Milliser 1974). Several investigators have deseribed (1957) and McCallum (1958McCallum ( , 1965 have the effects of Ia(hyrism on (he periodon-showtT that miee ean also be made lathy-tal ligament of rats without examining ritic when placed on a diet containing 50 % the oxytalan fiber (Gardner et al 1958, sweet pea seed {Lathyrtis odoratiis), or by Krikos et al 1958, Gardner 1959, Krikos SIMS 1959, Sciaky & Ungar 1961, Sarnat & Sciaky 1965 although the presence of oxytalan staining structures has been referred to by Gardner (1960) and Kennedy & Kennedy (1963).…”

mentioning

confidence: 99%

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The Oxytalan Fiber System in the Mandibular Periodontal Ligament of the Lathyritic Mouse

Sims

1977

J Oral Pathology Medicine

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Experimental lathyrism was produced in young albino mice with a diet containing 50 % sweet pea seed (Lathyrus odoratiis). After 7 days on the lathyritic diet, sections of the mandibular molar and incisor periodontal ligaments, when oxidized and treated wi(h aldehyde fuchsin, demonstrated enhanced staining of the oxytalan fibers and numerous vessels. At this time aldehyde fuchsin or orcein also revealed marked pathological changes in (he periodontal ligament of all molars. When lathyrism was prolonged for 12 weeks, both the molar and incisor oxytalan systems were still readily identifiable although the molar periodontal ligament continued to be severely affected by lathyrism. The oxytalan fibers retained their characteristic tooth-vascular association in all of the lathyritic mice. Oxytalan fibers of the lathyritic and control animals showed similar reactions to enzyme digestion with beta-glucuronidase, elastase, and pepsin. However, gingival elastic fibers reacted in a different way from oxytalan fibers with beta-glucuronidase and elastase treatment. These findings indicate that in (he lathyritic mouse the oxytalan fiber system of functioning teeth possesses a high degree of permanence and is metabolically distinct from collagen and elastic fibers.

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