An Ayurvedic formulation of Emblica officinalis and Curcuma longa alleviates insulin resistance in diabetic rats: Involvement of curcuminoids and polyphenolics

Panda, Vandana; Deshmukh, Amol S.; Singh, Sneha; Shah, Taasin; Hingorani, Lal

doi:10.1016/j.jaim.2021.05.005

Cited by 25 publications

(11 citation statements)

References 22 publications

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“…Curcumin leads to increased insulin secretion due to prevention of apoptosis and oxidative stress along with increased activity of antioxidant enzymes. On the other hand, studies show that Cur is associated with increased glucose uptake and utilization by skeletal muscle cells and adipocytes, and the inhibition of gluconeogenesis (Panda et al 2021). Gallic acid has been shown to improve insulin sensitivity since it regulates the expression of hepatic insulin signaling proteins such as insulin receptor, insulin receptor substrate 1 and phosphatidylinositol-3 kinase as demonstrated in mice fed with a high-fat diet.…”

Section: Resultsmentioning

confidence: 99%

Protective Effects of Gallic Acid and Curcumin on Serum Levels of Hepatic Transaminases, Blood Plasma Parameters and Pituitary-testicular Hormones in Rats Treated Nickel Nanoparticles

Motlagh

Vahdati

Hosseini

et al. 2022

JITV

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<p>Nickel nanoparticles (NiNPs) have toxic effects on body cells due to the production of free radicals. The purpose of this research was to investigate the protective effects of Gallic acid (GA) and Curcumin (Cur) on hepatic transaminases, blood plasma parameters and pituitary-testicular hormones levels in NiNPs-treated rats. Seventy adult male Wistar rats were divided in 7 groups of 10 including control, Ni50 mg/kg, Ni50+GA150 mg/kg, Ni50+GA300 mg/kg, Ni50+Cur150 mg/kg, Ni50+Cur300 mg/kg and Ni50+GA300+CUR300 mg/kg. NiNPs, GA and Cur were administered orally by oral gavage for 28 days. At the last phase of the study, the samples of blood were taken directly from heart and serum levels of hepatic transaminases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), blood plasma parameters (Glucose, total protein (TP), bilirubin (Bil), albumin (Alb), creatinine (Cr), Blood urea nitrogen (BUN), triglyceride, cholesterol, HDL, LDL and alkaline phosphatase (ALP)) and pituitary-testicular hormones (FSH, LH, testosterone and dihydrotestosterone) were assessed. NiNPs administration increased serum levels of glucose, ALT, ALP, AST, Bil, BUN, Cr, triglyceride, cholesterol and LDL compared to the control group (p<0.05) and in contrast, it decreased serum levels of FSH, LH, testosterone, dihydrotestosterone, Alb, TP and HDL (p<0.05). However, co-administration of GA and Cur at doses of 300 ml/kg in NiNPs -treated rats improved all blood plasma parameters compared to the control group (p>0.05). The findings of this study suggest that co-administration of GA and Cur at a dose of 300 mg/kg can reduce and improve the damaging effects of NiNPs on blood plasma parameters, hepatic transaminases and pituitary-testicular hormones in adult rats.</p>

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Section: Resultsmentioning

confidence: 99%

Protective Effects of Gallic Acid and Curcumin on Serum Levels of Hepatic Transaminases, Blood Plasma Parameters and Pituitary-testicular Hormones in Rats Treated Nickel Nanoparticles

Motlagh

Vahdati

Hosseini

et al. 2022

JITV

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“…Calculations of insulin sensitivity were performed using the homeostasis model assessment of insulin resistance (HOMA-IR) based on fasting blood glucose and insulin values: (Fasting plasma glucose concentration [mg/dL] ×Fasting plasma insulin concentration [mIU/L])/22.5. 28 A lower insulin sensitivity is indicated by an increase in HOMA-IR values. In order to calculate the Quantitative Insulin-sensitivity Check Index (QUICKI), we used the following formula: 1/(Fasting plasma insulin concentration [mIU/L] + Fasting plasma glucose concentration [mg/dL]).…”

Section: Methodsmentioning

confidence: 99%

Association Between Sex Hormone-Binding Globulin, Atherogenic Indices of Plasma Among Young Sedentary Males

Mohammadrezaei

Ardekani

Farhangi

et al. 2023

Nutr Metab Insights

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Background: Males are more likely than females to suffer from cardiovascular disease (CVD). So, sex hormones may modify these variations and affect the lipid profile. We examined the relationship between sex hormone-binding globulin (SHBG) and CVD risk factors among young males in this study. Methods: Using a cross-sectional design, we measured total testosterone, SHBG, lipids, glucose, insulin, antioxidant parameters, and anthropometric factors in 48 young males in the age range of 18 to 40 years. Atherogenic indices of plasma were calculated. In this study, a partial correlation analysis was carried out to assess the relationship between SHBG and other variables after adjustment for confounders. Results: According to the results of multivariable analyses adjusted for age and energy, SHBG had a negative correlation with total cholesterol ( r = −.454, P =.010), low-density lipoprotein cholesterol ( r = −.496, P =.005), quantitative insulin-sensitivity check index, and positive correlation with high-density lipoprotein cholesterol ( r = .463, P =.009). No significant correlation was observed between SHBG and triglycerides ( P >.05). Several atherogenic indices of plasma have a negative correlation with SHBG levels. These include Atherogenic Index of Plasma ( r = −.474, P = .006), Castelli Risk Index (CRI)1 ( r = −.581, P < .001), CRI2 ( r = −.564, P = .001), and Atherogenic Coefficient (r = −.581, P < .001). Conclusion: Among young men, high plasma SHBG was associated with reduced CVD risk factors, modified lipid profile and atherogenic ratios, and better glycemic markers. Therefore, reduced SHBG concentrations could be a prognostic marker of CVD among young sedentary males.

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“…sulfuric acid 4.5 mL). As indicated by earlier researchers, we also used GC-MS and LC-HRMS analysis to identify the bioactive compounds in the CXBCH [ 49 ].…”

Section: Methodsmentioning

confidence: 99%

Herbal Honey Preparations of Curcuma Xanthorriza and Black Cumin Protect against Carcinogenesis through Antioxidant and Immunomodulatory Activities in Sprague Dawley (SD) Rats Induced with Dimethylbenz(a)anthracene

et al. 2023

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Background: Traditionally, Curcuma xanthorriza (CX), black cumin seed (BC), and honey have been used by the Indonesian people as medicinal ingredients to treat various health symptoms. CX extracts and BC have been proven in the laboratory as chemopreventive agents, antioxidants, and immunomodulators. In this study, we developed CX extract, BC oil, and honey into herbal honey preparations (CXBCH) and hypothesized that the preparations show chemopreventive activity. The purpose of the study was to determine the CXBCH potential as chemopreventive, antioxidant, and immunomodulatory. Method: In this experimental laboratory research, antioxidant, immunomodulatory, and cytotoxic activities were tested on human mammary cancer cell lines (T47D cells) while the chemopreventive activity of the CXBCH preparations on Sprague Dawley (SD) rats induced with dimethylbenzene(a)anthracene (DMBA). Results: CXBCH preparations demonstrated immunomodulatory, antioxidant, and cytotoxic activities in T47D, Hela, and HTB-183 cells and in DMBA-induced SD rats, as the preparations inhibited tumor nodule formation, increased the number of CD4, CD8 and CD4CD25 cells, and glutathione-S-transferase (GST) activity, and decreased serum NO levels. Conclusions: CXBCH preparations display chemopreventive, antioxidant, and immunomodulatory properties.

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An Ayurvedic formulation of Emblica officinalis and Curcuma longa alleviates insulin resistance in diabetic rats: Involvement of curcuminoids and polyphenolics

Cited by 25 publications

References 22 publications

Protective Effects of Gallic Acid and Curcumin on Serum Levels of Hepatic Transaminases, Blood Plasma Parameters and Pituitary-testicular Hormones in Rats Treated Nickel Nanoparticles

Protective Effects of Gallic Acid and Curcumin on Serum Levels of Hepatic Transaminases, Blood Plasma Parameters and Pituitary-testicular Hormones in Rats Treated Nickel Nanoparticles

Association Between Sex Hormone-Binding Globulin, Atherogenic Indices of Plasma Among Young Sedentary Males

Herbal Honey Preparations of Curcuma Xanthorriza and Black Cumin Protect against Carcinogenesis through Antioxidant and Immunomodulatory Activities in Sprague Dawley (SD) Rats Induced with Dimethylbenz(a)anthracene

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