An eco-friendly protocol for synthesis of thiourea derivatives: 1-benzoyl-3-benzylguanidine and 1-benzoyl-3-benzyl-O-ethylisourea. A possible non-purely thermal microwave assisted reaction

Márquez, Heidy; Loupy, André; Calderon, O.; Pérez, Eliseo García

doi:10.1016/j.tet.2005.12.037

Cited by 27 publications

(12 citation statements)

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“…In conventional methodology, high reaction temperature and long reaction time are generally required to obtain good conversions and yields in these cycloaddition reactions but prolonged heating time results in a drastic drop of the yield of cycloadducts because of decomposition. A study of the reaction conditions under microwave irradiation was thus undertaken as this condition is generally faster, cleaner, and greener . The results are summarized in Table .…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Some Novel Class of Bis(isoxazoline) and Bis(aziridine) Derivatives

Chakraborty

Chettri

Luitel

2016

Journal of Heterocyclic Chem

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Synthesis of some new bis(isoxazoline) derivatives has been described from terepthaldehyde derived bis(nitrones) using microwave irradiation via 1,3‐dipolar cycloaddition reaction. Bis(isoxazoline) derivatives in turn successfully converted into new bis(aziridine) derivatives via Baldwin rearrangement. Simple reaction methodology, non involvement of catalysts, and good to excellent yields are the important features noticed in this synthesis.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Some Novel Class of Bis(isoxazoline) and Bis(aziridine) Derivatives

Chakraborty

Chettri

Luitel

2016

Journal of Heterocyclic Chem

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“…Compared to conventional heating, microwave irradiation often gives enhanced reaction rates and decreases the formation of byproducts (Alvarez et al, 2006;Dos Santos et al, 2004;Marquez et al, 2006). Microwave irradiation has been used for many organic reactions such as pericyclic (Srikrishna and Nagaraju, 1992), cyclization (Rama Rao et al, 1992), aromatic substitution (Laurent et al, 1994), oxidation (Gedye et al, 1986), alkylation (Yulin and Yuncheng, 1994), decarboxylation (Jones and Chapman, 1993), radical reactions (Bose et al, 1991), condensation (Sharma et al, 2011), and peptide synthesis (Yu et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antimicrobial activities of new mono and bisphenyl linked bispyrazole and bispyrazolone derivatives

Mehta¹,

Patel²,

Dixit

et al. 2017

Arabian Journal of Chemistry

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The entitled bispyrazole and bispyrazolone compounds (4a-4t) were synthesized in good yield using a simplified experimental procedure under both conventional and microwave heating from easily available starting materials. The structure of synthesized bispyrazole and bispyrazolone compounds (4a-4t) was established with the help of physico-chemical analysis and various spectroscopic techniques like FT-IR, Mass, 1 H NMR and 13 C NMR. The results of analyses are in good agreement with the proposed structure of all the synthesized compounds. Further, all the synthesized compounds were evaluated for their antimicrobial (antibacterial and antifungal) activities using various species like Bacillus subtilis, Escherichia coli, Aspergillous niger and Aspergillous flavus by using the agar cup method. The results of antimicrobial screening showed that compounds have mild to moderate activity. However, compounds 4g and 4h have shown good activity among all the tested compounds. ª 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.

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“…Resonances of aromatic carbon were observed at δ C 105.5-161.2 ppm. Two distinctive resonances at the most downfield region (δ C 166.0 and 177.3 ppm) can be observed which corresponded to carbonyl (C=O) and thione (C=S) respectively in both spectra of L1 and L2 [16,31,32]. This is due to formation of intramolecular hydrogen bonding and electronegativity effect of oxygen and sulphur atoms which pulled certain amount of electrons from both moieties and deshielded the resonances to higher chemical shift [13,33].…”

Section: Scheme 1 the General Synthetic Work-up Of Ionophores Synthesismentioning

confidence: 93%

THEORETICAL AND EXPERIMENTAL INVESTIGATION OF PYRIDYL-THIOUREA DERIVATIVES AS IONOPHORES FOR Cu(II) ION DETECTION

Khairul¹,

Hasan²,

Daud³

et al. 2016

MJAS

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Copper (II) ion chemical sensors based on pyridine-thiourea derivatives; N-pyridyl-N'-(biphenyl-4-carbonyl)thiourea (L1), and N-pyridyl-N'-(3,5-dimethyoxybenzoyl)thiourea (L2) were synthesised, characterised, and studied as ionophores in the form of thin-films PVC membranes. The ionophores exhibited good responses towards copper (II) ion over the concentration range of 2 x 10 -4 to 10 x 10 -4 M with a limit of detection 1.34 x 10 -5 to 1.48 x 10 -5 M. The proposed sensors L1 and L2 revealed good performance in term of reproducibility and regeneration of the ionophores with low relative standard deviation (RSD) values 4.17 % and 2.74 % respectively. Besides, quantum chemical calculation performed using Gaussian 09 program indicated the oxygen (O) atom from carbonyl moiety (C=O) was the most favourite reactive site and mainly responsible for ionophore-Cu(II) interaction. The obtained data revealed pyridine-thiourea derivatives offered great potential as ionophore for the detection of Cu (II) ion.

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An eco-friendly protocol for synthesis of thiourea derivatives: 1-benzoyl-3-benzylguanidine and 1-benzoyl-3-benzyl-O-ethylisourea. A possible non-purely thermal microwave assisted reaction

Cited by 27 publications

References 50 publications

Synthesis of Some Novel Class of Bis(isoxazoline) and Bis(aziridine) Derivatives

Synthesis of Some Novel Class of Bis(isoxazoline) and Bis(aziridine) Derivatives

Synthesis and antimicrobial activities of new mono and bisphenyl linked bispyrazole and bispyrazolone derivatives

THEORETICAL AND EXPERIMENTAL INVESTIGATION OF PYRIDYL-THIOUREA DERIVATIVES AS IONOPHORES FOR Cu(II) ION DETECTION

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