An Efficient and Sustainable Approach to Decarboxylative Cross-Coupling Using Silica Coated Magnetic Copper Nanocatalyst for the Synthesis of Internal Alkynes

Abstract

A highly efficient magnetically separable copper nanocatalyst has been developed for decarboxylative cross-coupling reaction for the alkynylation of haloarenes using alkynoic acid as a reaction partner. The chemical nature, morphology, size, and magnetic properties of the prepared nanocatalyst were studied by SEM, TEM, EDS, FT-IR, VSM, and ICP techniques. Remarkably, this catalyst represents the first successful copper based heterogeneous system for this type of coupling that provides a low-cost, stable, and environmentally friendly magnetically recoverable entity that can be re-used for seven consecutive runs without appreciable loss in its catalytic performance.

Transition metal-catalyzed alkynylation reactions via alkynyl carbon–carbon bond cleavage

“…On the other hand, Sharma and co-workers developed magnetically separable copper nanocatalyst Cu-DF@ASMNP and applied this catalyst in decarboxylative cross-coupling of alkynoic acid and haloarenes (Scheme 9). 22 The reaction provides the coupling products in good yields. The catalyst can be readily recovered and reused up to seven times without significant loss of activity.…”