Multiple constant multiplication (MCM) operation multiplies an input variable with multiple constants. MCM operations are widely used in many applications such as video processing and compression. In this paper, a method is proposed for efficient implementation of MCM operations using DSP blocks in Xilinx FPGAs. The proposed method reduces number of DSP blocks used for implementing a given MCM operation by manipulating the multiple constants used in this MCM operation. In this paper, a high level synthesis tool implementing the proposed method is also proposed. The proposed tool takes the input variable bit length and multiple constants as inputs, and generates a Verilog RTL code which efficiently implements this MCM operation using DSP blocks. The proposed method and tool are used for one of the most complex video compression algorithms, HEVC 2D DCT. They reduced number of DSP blocks used in the FPGA implementation of HEVC 2D DCT algorithm by 35.8%.