In theory, Polar codes do not exhibit an error floor under successive-cancellation (SC) decoding. In practice, frame error rate (FER) down to 10 −12 has not been reported with a real SC list (SCL) decoder hardware. This paper presents an asymmetric adaptive SCL (A2SCL) decoder, implemented in real hardware, for high-throughput and ultra-reliable communications. We propose to concatenate multiple SC decoders with an SCL decoder, in which the numbers of SC/SCL decoders are balanced with respect to their area and latency. In addition, a novel unequal-quantization technique is adopted. The two optimizations are crucial for improving SCL throughput within limited chip area. As an application, we build a link-level FPGA emulation platform to measure ultra-low FERs of 3GPP NR Polar codes (with parity-check and CRC bits). It is flexible to support all list sizes up to 8, code lengths up to 1024 and arbitrary code rates. With the proposed hardware, decoding speed is 7000 times faster than a CPU core. For the first time, FER as low as 10 −12 is measured and quantization effect is analyzed.