An Efficient Synthesis of Pyrido[3, 2‐<i>c</i>]coumarins under Microwave Irradiation in Solvent‐Free Conditions

Kolita, Sinki; Bhuyan, Pulak J.

doi:10.1002/slct.201702957

Cited by 16 publications

(7 citation statements)

References 30 publications

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“…Pyrido[3,2-c]coumarins were synthesized in the presence of ammonium acetate, the reaction was carried out with suitable starting materials. The yield obtained was good and the time required for the reaction was about 3-4 mins [60]. Synthesis of coumarin-thiazolidine-2,4-dione was carried out recently by Mangasuli and coworkers.…”

Section: New Approaches For the Synthesis Of Coumarins Derivatives 31...mentioning

confidence: 99%

Recent Methods for Synthesis of Coumarin Derivatives and Their New Applications

Sharma¹,

Dhayalan²,

Manikandan³

et al. 2023

Strategies for the Synthesis of Heterocycles and Their Applications

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Coumarin (2H-1-benzopyran-2-one) and its heterocyclic derivatives are widely used as lactone scaffolds used by innovative methods for the preparation of heterocyclic molecules. Nowadays, significant biological activities, as well as properties of unique nature coumarin derivatives, have played an important role in the development of novel drugs. This chapter entitles numerous methods of one-pot construction of coumarin derivatives, together with well-known name reactions and other type reactions as well, in the presence of various metal-based homogenous and heterogeneous catalyst system. Coumarin is one of the very important heterocycles and its analogs like natural product and pharmaceutically active drug molecules are extracted/isolated from a plants, animals, and microbes. Coumarin precursors have a wide range of biological activities Hence, the synthesis of coumarins and their heterocyclic analogs have become among the most interesting compound over the last many years in the growth of improved synthetic methodologies to form different types of functional groups that are present in coumarins derivatives. The synthesis of coumarins enabled by current approaches and their most recent bio-applications are discussed in this book chapter. Corresponding complex heterocycles-based coumarin analogs are produced from substituted alkyne substrates and other starting materials as well.

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Section: New Approaches For the Synthesis Of Coumarins Derivatives 31...mentioning

confidence: 99%

Recent Methods for Synthesis of Coumarin Derivatives and Their New Applications

Sharma¹,

Dhayalan²,

Manikandan³

et al. 2023

Strategies for the Synthesis of Heterocycles and Their Applications

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“…The same year, Kolita and Bhuyan demonstrated the synthesis of pyrido [3,2- c ]coumarins 262 , or 92k , 277a , b or 279a – c from the reaction of 4-chloro-3-formylcoumarin ( 251a ) with aryl methyl ketones 87 or ethyl acetoacetate ( 90k ) or ethyl cyanoacetate ( 272b ), respectively, in the presence of NH 4 OAc under microwave irradiation and solvent-free conditions [ 171 ]. An aldol condensation between 251a and 87a possibly occurred to give the intermediate A .…”

Section: Synthetic Strategies For the Preparation Of Fused Pyridocoum...mentioning

confidence: 99%

An Overview on the Synthesis of Fused Pyridocoumarins with Biological Interest

Douka¹,

Litinas²

2022

Molecules

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Pyridocoumarins are a class of synthetic and naturally occurring organic compounds with interesting biological activities. This review focuses on the synthetic strategies for the synthesis of pyridocoumarins and presents the biological properties of those compounds. The synthesis involves the formation of the pyridine ring, at first, from a coumarin derivative, such as aminocoumarins, hydroxycoumarins, or other coumarins. The formation of a pyranone moiety follows from an existing pyridine or piperidine or phenol derivative. For the above syntheses, [4 + 2] cycloaddition reactions, multi-component reactions (MCR), as well as metal-catalyzed reactions, are useful. Pyridocoumarins present anti-cancer, anti-HIV, antimalarial, analgesic, antidiabetic, antibacterial, antifungal, anti-inflammatory, and antioxidant activities.

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“…4H-Pyrano [3,2-c] coumarin derivatives are an important and attractive class of pharmaceutical compounds. They have anti-microbial, [11] anti-fungal, [12] antiinflammatory, [13] anti-tumor, [14] anti-HIV, [15] and anti-allergenic pharmacological activities(Scheme 1). [16] In addition, they can be used to treat Alzheimer's disease, Parkinson's disease, Down syndrome, and schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of 4H-Pyrano[3,2-c]coumarin Derivatives Catalyzed by Deep Eutectic Solvent

Xie

Yang

et al. 2021

Synthesis

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4H-Pyrano[3,2-c]coumarin derivatives are an important class of pharmaceutical compounds that are expensive to prepare by previously reported methods. An efficient and green method was developed to obtain these derivatives using the deep eutectic solvent (DES) zinc chloride/acetamide (n:n = 1:4), which acted as both the catalyst and the solvent for the reaction. An aromatic aldehyde, 4-hydroxycoumarin, and cyanoacetate were used as the substrates. The DES, substrate molar ratio, diluent type, temperature, and reaction time were optimized to obtain the 4H-pyrano[3,2-c]coumarin derivatives from a range of aromatic aldehydes in a single step in moderate to high yields and under mild reaction conditions.

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An Efficient Synthesis of Pyrido[3, 2‐c]coumarins under Microwave Irradiation in Solvent‐Free Conditions

Cited by 16 publications

References 30 publications

Recent Methods for Synthesis of Coumarin Derivatives and Their New Applications

Recent Methods for Synthesis of Coumarin Derivatives and Their New Applications

An Overview on the Synthesis of Fused Pyridocoumarins with Biological Interest

One-Pot Synthesis of 4H-Pyrano[3,2-c]coumarin Derivatives Catalyzed by Deep Eutectic Solvent

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