A simple and efficient method for the synthesis of highly functionalized indoles and biindoles was developed. In the reaction protocol, three components were used in one pot and products were obtained in high yield in an easy workup procedure. The reaction occurred via initial reductive alkylation of α-keto imines, followed by a cyclization process in the presence of PTSA/FeCl3 as catalyst.

Synthesized some novel functionalized pyrido[3, 2‐c] coumarins from the reaction of 4‐chloro‐3‐formylcoumarins obtained from 4‐hydroxycoumarins, and aryl methyl ketones/ethyl acetoacetate/ethyl cyanoacetate in the presence of ammonium acetate under microwave irradiation in solvent‐free condition in excellent yields.

An efficient protocol has been developed for the synthesis of some novel hexahydropyrimido[4,5-b]-1,8-naphthyridine derivatives by a one-pot three-component reaction of a 2-cyano-3-(1H-indol-3-yl)-pent-2-enedinitrile or ethyl-2,4-dicyano-3-(1H-indol-3-yl)but-2-enoate derivative with an aryl aldehyde and a 6-aminouracil derivative. The indole derivatives were prepared by the reaction of the corresponding 3-(cyanoacetyl)indoles with acetonitrile derivatives.

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Unsymmetrical bis(4-hydroxycoumarin-3-yl)methane derivatives have been synthesized from 4-hydroxycoumarins, aldehydes, and secondary amines via 3-(aminoalkyl)-4-hydroxycoumarin intermediates, followed by substitution.