An Emulsion Restores the Skin Barrier by Decreasing the Skin pH and Inflammation in a Canine Experimental Model

The influence of treatment with lokivetmab on transepidermal water loss (TEWL) in dogs with spontaneously occurring atopic dermatitis

“…Atopic dermatitis (AD) is a common allergic skin disease in dogs and the pathogenesis has been associated with disturbances in skin barrier function. [1][2][3][4][5] The assessment of skin barrier function, using biophysical methods, may include measurement of epidermal hydration, erythema, skin pH and, most commonly, transepidermal water loss (TEWL). [6][7][8][9] Increased transepidermal water loss was reported in the course of allergic disease in dogs.…”

Use of antipruritic and rehydrating foams on localized lesions of atopic dermatitis in dogs: a small‐scale pilot and comparative double‐blinded study

“…Topical foams are defined as products consisting of a large volume of air dispersed in a liquid and containing one or more active ingredients along with tensioactive agents . Douxo Calm ® mousse contains phytosphingosine (a proceramide, a constituent of the skin barrier lipids), pseudofilaggrin (a synthetic peptide which may support the impermeability of the skin barrier), stimutex‐AS (a complex of phytosterols which the manufacturer suggests may assist in the management of itching and irritation) and avenanthramides (colloidal oatmeal extracts to help reduce itching and inflammation) . ATOP 7 ® mousse contains ingredients derived from plant extracts (bisabolol, essential oil of lemon tea tree and caper flower bud extract) with properties to decrease pruritus and irritation .…”

A pilot study comparingin vitroefficacy of topical preparations against veterinary pathogens

“…One veterinary study showed no residual antimicrobial properties when canine corneocytes were treated with phytosphingosine‐containing shampoo, but other beneficial properties (e.g. restoring skin barrier, reducing cutaneous pH and inflammation) have been described …”