An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers

Abstract

A multifunctional nanoplatform with four-in-one photoresponsive functionalities has been achieved through the co-encapsulation of two chromo-fluorogenic components within biocompatible polymeric nanoparticles. This engineered nanoconstruct efficiently delivers different photosensitizers in melanoma cells, which can be detected through their dual-color fluorescence, and induces amplified cell mortality due to the simultaneous photogeneration of singlet oxygen and nitric oxide.

A multifunctional nanoplatform for lysosome targeted delivery of nitric oxide and photothermal therapy under 808 nm near-infrared light

“…24,25 NO-hybrid composites that combine NO to existing drugs such as photosensitizing agents used in photodynamic therapy might afford an advantage of combining the effects of NO with the benefits of drugs to overcome tumor cell resistance to conventional therapeutic agents. 17,18,26,27 Photothermal therapy (PTT), which is based on the principle of converting light energy into heat to generate hyperthermia, is another promising effective treatment for tumor necrosis because of its high selectivity and noninvasiveness. 28,29 Various nanomaterials, including noble metal nanomaterials, semiconductor nanomaterials, and carbon-based nanomaterials, have been demonstrated to exhibit encouraging photothermal therapeutic effects in vitro and in vivo.…”

Photo-Controlled Release of NO and CO with Inorganic and Organometallic Complexes

“…In order to protect the photoCORMs from ketone hydration, the derivatives were encapsulated in Pluronic 127 micelles-a biocompatible block copolymer with polyethylene and polypropylene oxides commonly used for drug delivery [167]. The micelle interior is highly hydrophobic, enabling both the PEG-and alkyl-functionalized photoCORMs to be incorporated.…”

Polymeric nanoparticles for optical sensing

“…A novel dual-color system has been recently developed for both cancer imaging and therapy by means of the simultaneous production of nitric oxide and singlet oxygen triggered by light (Fraix et al, 2013). The advantage of such a system relies in the synergistic effect of the species generated, since both NO radical and 1 O 2 possess promising anticancer activity, thus improving the efficiency of the cancer therapy.…”